Racial and ethnic disparities in the survival of adolescents and young adults with acute myeloid leukemia: a retrospective study using the US National Cancer Data Base

2016 ◽  
Vol 58 (5) ◽  
pp. 1184-1189 ◽  
Author(s):  
Urshila Durani ◽  
Ronald S. Go
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Retrospective Study ◽  
Myeloid Leukemia ◽  
Ethnic Disparities ◽  
National Cancer Data Base ◽  
Racial And Ethnic Disparities ◽  
Cancer Data ◽  
The Us ◽  
Acute Myeloid

scholarly journals Improved outcome in children compared to adolescents and young adults after allogeneic hematopoietic stem cell transplant for acute myeloid leukemia: a retrospective study from the Francophone Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC)

2021 ◽  
Author(s):  
Cécile Pochon ◽  
Marie Detrait ◽  
Jean-Hugues Dalle ◽  
Gérard Michel ◽  
Nathalie Dhédin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Retrospective Study ◽  
Myeloid Leukemia ◽  
Chronic Gvhd ◽  
Intermediate Risk ◽  
Allogeneic Hsct ◽  
Acute Myeloid

Abstract Background There are currently few data on the outcome of acute myeloid leukemia (AML) in adolescents after allogeneic HSCT. The aim of this study is to describe the outcome and its specific risk factors for children, adolescents and young adults after a first allogeneic HSCT for AML. Methods In this retrospective study, we compared the outcome of AML patients receiving a first allogeneic HSCT between 2005 and 2017 according to their age at transplantation’s time: children (< 15 years, n = 564), adolescent and post-adolescent (APA) patients (15–25 years, n = 647) and young adults (26–40 years; n = 1434). Results With a median follow-up of 4.37 years (min–max 0.18–14.73 years), the probability of 2-year overall survival (OS) was 71.4% in children, 61.1% in APA patients and 62.9% in young adults (p = 0.0009 for intergroup difference). Both relapse and non-relapse mortality (NRM) Cumulative Incidence (CI) estimated at 2 years were different between the age groups (30.8% for children, 35.2% for APA patients and 29.4% for young adults—p = 0.0254, and 7.0% for children, 10.6% for APA patients and 14.2% for young adults, p < 0.0001; respectively). Whilst there was no difference between the three groups for grade I to IV acute GVHD CI at 3 months, the chronic GVHD CI at 2 years was higher in APA patients and young adults (31.4% and 36.4%, respectively) in comparison to the children (17.5%) (p < 0.0001). In multivariable analysis, factors associated with death were AML cytogenetics (HR1.73 [1.29–2.32] for intermediate risk 1, HR 1.50 [1.13–2.01] for intermediate risk 2, HR 2.22 [1.70–2.89] for high cytogenetics risk compared to low risk), use of TBI ≥ 8 Grays (HR 1.33 [1.09–1.61]), disease status at transplant (HR 1.40 [1.10–1.78] for second Complete Remission (CR), HR 2.26 [1.02–4.98] for third CR and HR 3.07 [2.44–3.85] for active disease, compared to first CR), graft source (HR 1.26 [1.05–1.50] for Peripheral Blood Stem Cells compared to Bone Marrow) and donor age (HR 1.01 (1–1.02] by increase of 1 year). Conclusion Age is an independent risk factor for NRM and extensive chronic GVHD. This study suggests that APA patients with AML could be beneficially treated with a chemotherapy-based MAC regimen and bone marrow as a stem cells source.

scholarly journals Extramedullary acute myeloid leukemia presenting in young adults demonstrates sensitivity to high-dose anthracycline: a subset analysis from ECOG-ACRIN 1900

Haematologica ◽  
2018 ◽  
Vol 104 (4) ◽  
pp. e147-e150 ◽  
Author(s):  
Hugo F. Fernandez ◽  
Zhuoxin Sun ◽  
Mark R. Litzow ◽  
Selina M. Luger ◽  
Elisabeth Paietta ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Adults ◽  
Myeloid Leukemia ◽  
High Dose ◽  
Subset Analysis ◽  
Acute Myeloid
Sign in / Sign up

Export Citation Format

Share Document