The effect of benzodiazepines on exercise in healthy adult participants: A systematic review

Author(s):  
Darías Holgado, ◽  
Agustín Manresa-Rocamora, ◽  
Lorenzo Zamboni, ◽  
Fabio Lugoboni, ◽  
Ana María Peiró, ◽  
...  
2018 ◽  
Vol 8 (3) ◽  
pp. 361-370 ◽  
Author(s):  
Bonnie C. Shaddinger ◽  
Georgios Vlasakakis ◽  
Joseph Soffer ◽  
Karl M. Thorpe ◽  
Daniel Hatch ◽  
...  

2018 ◽  
Vol 48 (5) ◽  
pp. 1165-1187 ◽  
Author(s):  
Armin H. Paravlic ◽  
Maamer Slimani ◽  
David Tod ◽  
Uros Marusic ◽  
Zoran Milanovic ◽  
...  

Author(s):  
Arash Mahnan ◽  
Jessica Holst-Wolf ◽  
Jürgen Konczak

Abstract Proprioceptive afferents from the ankle joint are essential feedback for maintaining balance. However, there is no widely accepted test or measurement system available for determining the proprioceptive accuracy of the human ankle joint. Here, we present a system with a novel hardware design that applies an established psychometric testing protocol that generates a Just-Noticeable-Difference (JND) threshold as a measure of ankle proprioceptive acuity at the end of testing. To establish the system validity, twelve healthy adult participants completed the assessment. Testing required 25 trials and took approximately 10 minutes to complete. We show exemplar data of the ankle JND threshold and the summary results for all twelve participants. This assessment has the potential to become a tool for clinicians to identify proprioceptive impairment at the ankle and to assess the efficacy of sensorimotor interventions for improving balance in clinical populations.


2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S529-S529
Author(s):  
Eric Wenzler ◽  
Susan C Bleasdale ◽  
Monica K Sikka ◽  
Kristen Bunnell ◽  
Matthew Finnemeyer ◽  
...  

2018 ◽  
Author(s):  
Maria Montefinese ◽  
David Vinson ◽  
Gabriella Vigliocco ◽  
Ettore Ambrosini

Age of acquisition (AoA) is an important psycholinguistic variable that affects the performance of healthy individuals and patients in a large variety of cognitive tasks. For this reason, it becomes more and more compelling to collect new AoA norms for a large set of stimuli in order to allow better control and manipulation of AoA in future research. An important motivation of the present study is to extend previous Italian norms by collecting AoA ratings for a much larger range of Italian words for which concreteness and semantic-affective norms are now available thus ensuring greater coverage of words varying along these dimensions. In the present study, we collected AoA ratings for 1,957 Italian content words (adjectives, nouns and verbs), by asking healthy adult participants to estimate the age at which they thought they had learnt the word in a Web survey procedure. First, we found high split-half correlation within our sample, suggesting strong internal reliability. Second, our data indicate that the ratings collected in this study are as valid and reliable as those collected in previous studies for Italian across different age populations (adult and children) and other languages. Finally, we analyzed the relation between AoA ratings and other lexical-semantic variables (e.g. word frequency, imageability, valence, arousal) and showed that these correlations were generally consistent with the correlations reported in other normative studies for Italian and other languages. Therefore, our new AoA norms are a valuable source of information for future research in the Italian language. The datasets for this study can be found at the Open Science Framework repository (osf.io/3trg2).


Author(s):  
Ancor Serrano Afonso ◽  
Thiago Carnaval ◽  
Sebastiá Videla Cés

Pharmacological treatment is poorly effective for neuropathic pain (NP). A progressive decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in multimodal analgesic approach. We performed a systematic review to assess whether there is more and better-quality evidence available since the last review. We evaluated the efficacy, tolerability and safety of double-blind randomized controlled trials involving only adult participants comparing combination therapy (CT: ≥ 2 drugs) to placebo and/or at least one other comparator with NP indication. The primary outcome was the proportion of participants reporting ≥ 50% pain reduction from baseline. Secondary outcome was the proportion of drop-outs due to treatment-emergent-adverse-events. After removing duplicates, 2323 citations were screened. 164 articles were assessed for eligibility, from which 16 were included for qualitative analysis. From the latter, only 5 lasted for at least 12 weeks and only 6 complied with required data for complete analysis, but not for meta-analysis. CT has been adopted for years without robust evidence. Efforts to achieve better quality evidence have not improved over the years. In this regard, guidelines for NP should attempt to make recommendations on CT research, prioritizing which combinations to analyze.


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