Examination of the Higuchi Model for the Release of Vitamin B2from Multilayered Calcium Alginate/Chitosan Beads in Varying pH Medium

In this work alginate and alginate-chitosan beads containing celecoxib solubilized into a self-emulsifying phase were developed in order to obtain a drug delivery system for oral administration, able to delay the drug release in acidic environment and to promote it in the intestinal compartment. The rationale of this work was linked to the desire to improve celecoxib therapeutic effectiveness reducing its gastric adverse effects and to favor its use in the prophylaxis of colon cancer and as adjuvant in the therapy of familial polyposis. The systems were prepared by ionotropic gelation using needles with different diameters (400 and 600 μm). Morphology, particle size, swelling behavior, andin vitrodrug release performance of the beads in aqueous media with different pH were investigated. The experimental results demonstrated that the presence of chitosan in the formulation caused an increase of the mechanical resistance of the bead structure and, as a consequence, a limitation of the bead swelling ability and a decrease of the drug release rate at neutral pH. Alginate-chitosan beads could be a good tool to guarantee a celecoxib colon delivery.

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Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate–chitosan beads

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2006.05.054 ◽

2006 ◽

Vol 323 (1-2) ◽

pp. 34-42 ◽

Cited By ~ 283

Author(s):

George Pasparakis ◽

Nikolaos Bouropoulos

Keyword(s):

Calcium Alginate ◽

In Vitro Release ◽

Chitosan Beads ◽

Swelling Studies ◽

Vitro Release

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Preparation of active corn peptides from zein through double enzymes immobilized with calcium alginate–chitosan beads

Process Biochemistry ◽

10.1016/j.procbio.2014.07.002 ◽

2014 ◽

Vol 49 (10) ◽

pp. 1682-1690 ◽

Cited By ~ 30

Author(s):

Yanwei Wang ◽

Haixia Chen ◽

Jia Wang ◽

Lisha Xing

Keyword(s):

Calcium Alginate ◽

Chitosan Beads

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Kinetic Investigation of Hg(II) Photoreduction using TiO2-immobilized on Calcium Alginate Beads: Effect of Ferric ion and Organic Compound

Int'l Conf. on Chemical Engineering & Advanced Computational Technologies (ICCEACT’2014) Nov. 24-25, 2014 Pretoria (South Africa) ◽

10.15242/iie.e1114006 ◽

2014 ◽

Keyword(s):

Organic Compound ◽

Calcium Alginate ◽

Alginate Beads ◽

Ferric Ion ◽

Kinetic Investigation ◽

Calcium Alginate Beads

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A Dual Sensor for Biogenic Amines and Oxygen Based on Genipin Immobilized in Edible Calcium Alginate Gel Beads

10.26434/chemrxiv.12252323 ◽

2020 ◽

Author(s):

Ian Mallov ◽

Fiona Jeeva ◽

Chris Caputo

Keyword(s):

Biogenic Amines ◽

Calcium Alginate ◽

Alginate Beads ◽

Colorimetric Sensing ◽

Naturally Occurring ◽

Gel Beads ◽

Dual Sensor ◽

Calcium Alginate Gel ◽

Toxic Food

Food is often wasted due to real or perceived concerns about preservation and shelf life. Thus, precise, accurate and consumer-friendly methods of indicating whether food is safe for consumers are drawing great interest. The colorimetric sensing of biogenic amines released as food degrades is a potential way of determining the quality of the food. Herein, we report the use of genipin, a naturally occurring iridoid, as a dual colorimetric sensor for both oxygen and biogenic amines. Immobilization of genipin in edible calcium alginate beads demonstrates that it is a capable sensor for amine vapors and can be immobilized in a non-toxic, food-friendly matrix.

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Nitrification and Autotrophic Denitrification in Calcium Alginate Beads

Water Science & Technology ◽

10.2166/wst.1987.0199 ◽

1987 ◽

Vol 19 (1-2) ◽

pp. 175-182 ◽

Cited By ~ 16

Author(s):

Z. Lewandowski ◽

R. Bakke ◽

W. G. Characklis

Keyword(s):

Calcium Carbonate ◽

Calcium Ions ◽

Continuous Flow ◽

Calcium Alginate ◽

Microbial Respiration ◽

Flow System ◽

Alginate Beads ◽

Alginate Gel ◽

Gel Beads ◽

Calcium Alginate Gel

Immobilization of nitrifiers and autotrophic denitrifiers (Thiobacillus denitrificans) within calcium alginate gel was demonstrated. Calcium carbonate reagent was immobilized along with bacteria as the stabilizing agent. Protons released as a result of microbial respiration reacted with calcium carbonate producing calcium ions which internally stabilized the calcium alginate gel. The microbially active gel beads were mechanically stable and active for three months in a continuous flow system without addition of calcium.

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