Feasibility of Polyvinyl Alcohol as a Transdermal Drug Delivery System for Terbutaline Sulphate

2007 ◽  
Vol 44 (6) ◽  
pp. 583-589 ◽  
Author(s):  
T. M. Pramod Kumar ◽  
H. M. Umesh ◽  
H. G. Shivakumar ◽  
Valluru Ravi ◽  
Siddaramaiah
2011 ◽  
Vol 338 ◽  
pp. 42-45 ◽  
Author(s):  
Tanasait Ngawhirunpat ◽  
Theerasak Rojanarata ◽  
Suwannee Panomsuk ◽  
Praneet Opanasopit

The aim of this study was to prepare and characterize electrospun polyvinyl alcohol (PVA) nanofiber mats loaded with capsaicin (CC) as a transdermal drug delivery system. The amount of CC loaded in the base PVA solution (10 %w/v solution) was 0.025, 0.0375 and 0.05 %, based on the dry weight of PVA (% wt). The average diameters of these fibers ranged from 121 to 165 nm. In all concentrations of CC loaded in spun PVA fiber mats, an amorphous nanodispersion of CC with PVA was obtained. The tensile strength of the as-spun fiber mats was lower than that of the as-cast PVA films. The release rate of CC from CC-loaded as-spun PVA was significantly higher than from CC-loaded as-cast PVA films, and increased when the CC content in both CC-loaded as-spun PVA and CC-loaded as-cast PVA films increased. Our research suggests a potential use for CC-loaded electrospun PVA mats as a transdermal drug delivery system.


Author(s):  
Asif Eqbal ◽  
Vaseem Ahamad Ansari ◽  
Abdul Hafeez ◽  
Farogh Ahsan ◽  
Mohd Imran ◽  
...  

Nanoemulsions are drug transporters for the delivery of therapeutic agents. They possess the small droplet size having the range of 20×10-9-200×10-9m. The main purpose of using Nanoemulsion is to enhance the drug bio- availability of transdermal drug delivery system. With the help of phase diagram, we can select the components of nanoemulsion depending upon formulas ratio of oil phase, surfactant/co-surfactant and water phase. Nanoemulsion directly used as a topical drug delivery in skin organs. The most useable pharmaceutical application has been developed till date to provide systemic effects to penetrating the full thickness of skin organ layer nanoemulsions can be administered through variety of routes such as percutaneous, perioral, topical, transdermal, ocular and parental administration of medicaments. Nanoemulsions are transparent and slightly opalescent. Nanoemulsion can be prepared through various methods. Nanoemulsions are transparent and slightly opalescent. Factor affecting nanoemulsions are surfactant, viscosity, lipophilic, drug content, pH, concentration of each component, and methodology of formulation. It is unfeasible to test all factors at the various levels. Design of formulation when it comes to experimental design it gives an excellent approach through reducing the time and money.


Author(s):  
Lakshmi Usha Ayalasomayajula ◽  
M. Kusuma Kumari ◽  
Radha Rani Earle

In the recent days about 75% of the drugs taken orally are does not show the desired therapeutic effect. Oral conventional dosage forms have several disadvantages such as poor bioavailability due to hepatic first pass metabolism and tendency to produce rapid blood level spikes (Both high and low). Thus, rapid drug levels in the plasma leads to a need of high and/or frequent dosing, which can be both uneconomical and inconvenient. To overcome such disadvantages transdermal drug delivery system was developed. TDDS is such a delivery system which has been explored extensively over the last two decades, with therapeutic success. Transdermal drug delivery systems (TDDS) are the drug delivery systems which involves transportation of drug to epidermal and dermal tissues of the skin for local therapeutic action while major fraction of the drug is transported into the systemic blood circulation. Topical administration of therapeutic agents offers vast advantages over conventional oral and invasive methods of drug delivery. Some of the advantages of transdermal drug delivery include limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady state plasma level concentration of the drug. This study includes a brief overview of TDDS, its advantages over conventional dosage forms, drug delivery routes across human skin, permeation enhancers, and classification, formulation, methods of preparation and evaluation of transdermal patches.


2017 ◽  
Vol 17 (4) ◽  
pp. 488-494 ◽  
Author(s):  
Pranavi Jadhav ◽  
Ramen Sinha ◽  
Uday Kiran Uppada ◽  
Prabhat K. Tiwari ◽  
A. V. S. S. Subramanya Kumar

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