Nebulized anionic guanidinylated O-carboxymethyl chitosan/N-2-hydroxypropyltimehyl ammonium chloride chitosan nanoparticles for siRNA pulmonary delivery: preparation, characterization and in vitro evaluation

2017 ◽  
Vol 25 (5) ◽  
pp. 451-462 ◽  
Author(s):  
Suhui Ni ◽  
Yuwen Xie ◽  
Yue Tang ◽  
Yun Liu ◽  
Jing Chen ◽  
...  
Keyword(s):  
Ammonium Chloride ◽  
Chitosan Nanoparticles ◽  
Pulmonary Delivery ◽  
Carboxymethyl Chitosan ◽  
In Vitro Evaluation

In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery

2010 ◽  
Vol 21 (5) ◽  
pp. 1587-1597 ◽  
Author(s):  
Sumanta K. Sahu ◽  
Sanjay K. Mallick ◽  
Susmita Santra ◽  
Tapas K. Maiti ◽  
Sudip K. Ghosh ◽  
...  
Keyword(s):  
Folic Acid ◽  
Targeted Delivery ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan ◽  
In Vitro Evaluation

Preparation and in vitro evaluation of FGF-2 incorporated carboxymethyl chitosan nanoparticles

2017 ◽  
Vol 173 ◽  
pp. 114-120 ◽  
Author(s):  
Cong-Thuan Nguyen ◽  
Thanh-Thao Nguyen ◽  
Thu-Thuy Nguyen ◽  
Phuong Phong Thi Nguyen ◽  
Anh Dzung Nguyen ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan ◽  
In Vitro Evaluation

scholarly journals Probing Critical Physical Properties of Lactose-Polyethylene Glycol Microparticles in Pulmonary Delivery of Chitosan Nanoparticles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1581
Author(s):  
Nasser Alhajj ◽  
Idanawati Naharudin ◽  
Paolo Colombo ◽  
Eride Quarta ◽  
Tin Wui Wong
Keyword(s):  
Polyethylene Glycol ◽  
Surface Area ◽  
Chitosan Nanoparticles ◽  
Pulmonary Delivery ◽  
Drying Method ◽  
Adsorption Phenomenon ◽  
Molecular Weights ◽  
Nanoparticle Agglomeration ◽  
Peripheral Lung

Pulmonary delivery of chitosan nanoparticles is met with nanoparticle agglomeration and exhalation. Admixing lactose-based microparticles (surface area-weighted diameter~5 μm) with nanoparticles mutually reduces particle agglomeration through surface adsorption phenomenon. Lactose-polyethylene glycol (PEG) microparticles with different sizes, morphologies and crystallinities were prepared by a spray drying method using varying PEG molecular weights and ethanol contents. The chitosan nanoparticles were similarly prepared. In vitro inhalation performance and peripheral lung deposition of chitosan nanoparticles were enhanced through co-blending with larger lactose-PEG microparticles with reduced specific surface area. These microparticles had reduced inter-microparticle interaction, thereby promoting microparticle–nanoparticle interaction and facilitating nanoparticles flow into peripheral lung.

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