Determination of Sulfadimethoxine, Sulfamethoxazole, Trimethoprim and Their Main Metabolites in Lung and Edible Tissues from Pigs by Multi-Dimensional Liquid Chromatography

1993 ◽  
Vol 16 (1) ◽  
pp. 257-278 ◽  
Author(s):  
M. J. B. Mengelers ◽  
A. M. M. Polman ◽  
M. M. L. Aerts ◽  
H. A. Kuiper ◽  
A. S. J. P. A. M. Van Miert
1998 ◽  
Vol 81 (3) ◽  
pp. 519-527 ◽  
Author(s):  
Jean-michel Delmas ◽  
Anne-marie Chape ◽  
Pascal Sanders

abstract A simple, sensitive, and rapid method for simultaneous determination of residues of flumequine and its microbiologically active metabolite 7-hydroxyflumequine in 100 mg sheep edible tissues (muscle, liver, kidney, and fat) by liquid chromatography is reported. After liquid-liquid cleanup with ethyl acetate, tissue extracts were injected onto a Select B column. The 2 compounds were determined by ultraviolet and fluorimetric detection. The method was repeatable and reproducible for flumequine and 7-hydroxyflumequine in muscle, liver, kidney, and fat, with limits of detection below 2 and 3 μg/kg for flumequine and 7-hydroxyflumequine, respectively. Mean recoveries for flumequine were 90 ± 7, 82 ± 7,89 ± 5, and 82 ± 6% in muscle, liver, kidney, and fat, respectively. Mean recoveries for 7-hydroxyflumequine were 91 ± 2, 90 ± 4, 86 ± 3, and 84 ± 4% in muscle, liver, kidney, and fat, respectively.


2019 ◽  
Vol 1118-1119 ◽  
pp. 203-209 ◽  
Author(s):  
Meiyu Zhang ◽  
Jingli Qiu ◽  
Xuezhi Li ◽  
Weiguang Zhang ◽  
Jun Fan ◽  
...  

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