3D printing in the design of pharmaceutical dosage forms

2019 ◽  
Vol 24 (8) ◽  
pp. 1044-1053 ◽  
Author(s):  
E. B. Souto ◽  
J. C. Campos ◽  
S. C. Filho ◽  
M. C. Teixeira ◽  
C. Martins-Gomes ◽  
...  
Keyword(s):  
3D Printing ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms

scholarly journals DEM based investigation of powder packing in 3D printing of pharmaceutical tablets

2021 ◽  
Vol 249 ◽  
pp. 14012
Author(s):  
Koyel Sen ◽  
Tanu Mehta ◽  
Anson W.K.Ma ◽  
Bodhisattwa Chaudhuri
Keyword(s):  
3D Printing ◽  
Particle Density ◽  
Numerical Models ◽  
Dosage Forms ◽  
Raw Material ◽  
Pharmaceutical Dosage Forms ◽  
Printing Process ◽  
Powder Bed ◽  
Pharmaceutical Tablets ◽  
Powder Packing

3D printing is emerging as one of the most promising methods to manufacture Pharmaceutical dosage forms as it offers multiple advantages such as personalization of dosage forms, polypill, fabrication of complex dosage forms etc. 3D printing came into existence in 1980s but its use was extended recently to pharmaceutical industry along with the approval of first 3D printed tablet Spritam by FDA in 2015. Spritam was manufactured by Aprecia pharmaceuticals using binder jetting technology. Binder jet 3D printing involves a hopper for powder discharge and printheads for ink jetting. The properties of tablets are highly dependent upon the discharge quality of powder mixture from the hopper and jetting of the ink/binder solution from the printhead nozzle. In this study, numerical models were developed using Discrete element method (DEM) to gain better understanding of the binder jet 3D printing process. The DEM modeling of hopper discharge was performed using in-house DEM code to study the effect of raw material attributes such as powder bed packing density (i.e. particle size, particle density etc) on the printing process, especially during powder bed preparation. This DEM model was further validated experimentally, and the model demonstrated good agreement with experimental results.

A Critical Review on 3D-printed Dosage Forms

2019 ◽  
Vol 24 (42) ◽  
pp. 4957-4978 ◽  
Author(s):  
Ilias El Aita ◽  
Hanna Ponsar ◽  
Julian Quodbach
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Critical Evaluation ◽  
Dosage Forms ◽  
Review Article ◽  
Current Status ◽  
Comprehensive Overview ◽  
Pharmaceutical Dosage Forms ◽  
Advantages And Disadvantages ◽  
Pharmaceutical Application

Background: In the last decades, 3D-printing has been investigated and used intensively in the field of tissue engineering, automotive and aerospace. With the first FDA approved printed medicinal product in 2015, the research on 3D-printing for pharmaceutical application has attracted the attention of pharmaceutical scientists. Due to its potential of fabricating complex structures and geometrics, it is a highly promising technology for manufacturing individualized dosage forms. In addition, it enables the fabrication of dosage forms with tailored drug release profiles. Objective: The aim of this review article is to give a comprehensive overview of the used 3D-printing techniques for pharmaceutical applications, including information about the required material, advantages and disadvantages of the respective technique. Methods: For the literature research, relevant keywords were identified and the literature was then thoroughly researched. Conclusion: The current status of 3D-printing as a manufacturing process for pharmaceutical dosage forms was highlighted in this review article. Moreover, this article presents a critical evaluation of 3D-printing to control the dose and drug release of printed dosage forms.

Binder-Jet 3D Printing of Indomethacin-laden Pharmaceutical Dosage Forms

2020 ◽  
Vol 109 (10) ◽  
pp. 3054-3063
Author(s):  
Shing-Yun Chang ◽  
Si Wan Li ◽  
Kavin Kowsari ◽  
Abhishek Shetty ◽  
Leila Sorrells ◽  
...  
Keyword(s):  
3D Printing ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms

scholarly journals Functions of Magnetic Nanoparticles in Selective Laser Sintering (SLS) 3D Printing of Pharmaceutical Dosage Forms

2021 ◽  
Author(s):  
Yu Zhang ◽  
Jiaxiang Zhang ◽  
Rishi Thakkar ◽  
Amit R Pillai ◽  
Jiawei Wang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
3D Printing ◽  
Carbonyl Iron ◽  
Drug Delivery Systems ◽  
Selective Laser Sintering ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
First Time

<p><a>Selective laser sintering (SLS) 3D printing (3DP) offers novel opportunities for manufacturing various pharmaceutical dosage forms with a wide array of drug delivery systems. The purpose of this research was to introduce ferromagnetic nanoparticles, for the first time, as a multi-functional magnetic and heat conductive ingredient for 3DP tablet formulations, and further to analyze its effect on the drug release of the SLS printed tablets under a specially designed magnetic field. Optimization of tablet quality was performed by adjusting SLS printing parameters. </a>The independent factors studied were laser scanning speed (2, 50, 100, and 200 mm/s), hatching space (13, 25, 50, 100, 300, and 2000 µm), and temperature. The responses measured were tablet weight, hardness, disintegration time (DT), and dissolution kinetics studied within the first hour. The content uniformity, chemical interaction, drug distribution, and surface morphology were tested for characterizing the printed dosage forms. It has been observed, for the drug formulations with carbonyl iron, due to its inherent heat conductivity, that sintering tablets required low energy input compared to that of other batches that contained no magnetic particles, to make the tablets of the same quality attributes. Also, under the magnetic field, printed tablets with carbonyl iron released 25% more drug as compared to those without. Therefore, we report for the first time the use of magnetic nanoparticles as a novel conductive excipient to sinter the particles in an SLS 3D printing process of pharmaceutical dosage forms and hence this finding opens up numerous opportunities for magnetically triggerable drug delivery systems.</p>

scholarly journals Functions of Magnetic Nanoparticles in Selective Laser Sintering (SLS) 3D Printing of Pharmaceutical Dosage Forms

2021 ◽  
Author(s):  
Yu Zhang ◽  
Jiaxiang Zhang ◽  
Rishi Thakkar ◽  
Amit R Pillai ◽  
Jiawei Wang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
3D Printing ◽  
Carbonyl Iron ◽  
Drug Delivery Systems ◽  
Selective Laser Sintering ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
First Time

<p><a>Selective laser sintering (SLS) 3D printing (3DP) offers novel opportunities for manufacturing various pharmaceutical dosage forms with a wide array of drug delivery systems. The purpose of this research was to introduce ferromagnetic nanoparticles, for the first time, as a multi-functional magnetic and heat conductive ingredient for 3DP tablet formulations, and further to analyze its effect on the drug release of the SLS printed tablets under a specially designed magnetic field. Optimization of tablet quality was performed by adjusting SLS printing parameters. </a>The independent factors studied were laser scanning speed (2, 50, 100, and 200 mm/s), hatching space (13, 25, 50, 100, 300, and 2000 µm), and temperature. The responses measured were tablet weight, hardness, disintegration time (DT), and dissolution kinetics studied within the first hour. The content uniformity, chemical interaction, drug distribution, and surface morphology were tested for characterizing the printed dosage forms. It has been observed, for the drug formulations with carbonyl iron, due to its inherent heat conductivity, that sintering tablets required low energy input compared to that of other batches that contained no magnetic particles, to make the tablets of the same quality attributes. Also, under the magnetic field, printed tablets with carbonyl iron released 25% more drug as compared to those without. Therefore, we report for the first time the use of magnetic nanoparticles as a novel conductive excipient to sinter the particles in an SLS 3D printing process of pharmaceutical dosage forms and hence this finding opens up numerous opportunities for magnetically triggerable drug delivery systems.</p>

3D Printing Technology in Pharmaceutical Dosage forms: Advantages and Challenges

2021 ◽  
Vol 22 ◽  
Author(s):  
Prasanna Kumar Desu ◽  
Balaji Maddiboyina ◽  
Vanitha K. ◽  
GSN Koteswara Rao ◽  
Anusha R. ◽  
...  
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Printing Technology ◽  
Pharmaceutical Dosage Forms ◽  
3D Printing Technology ◽  
Solid Dosage ◽  
Personalized Medicines

Three Dimensional (3D) Printing is a promising method for quick prototyping and manufacturing of any material. It is similar to photocopy or printing, where the new materials are formed on layers (3D) like its mother component. Following its growth and advancement in the 1980s, its application in pharmaceuticals is still limited. It has become one of the most innovative and influential tools serving as a technology of precise manufacturing of developed dosage forms from the last decade. The potential of 3D printing to produce drugs for precise measurement customized to specific patients' needs has shown the possibility of developing personalized medicines to novel dosage forms. The breakthrough allows the clear perception of the dosage structures on different shapes, sizes, and surfaces challenging to deliver using Designed conditions. There are different difficulties related to the correct utilization of 3D imprinting in the pharmaceutical Part, which ought to be defeated to abuse the extent of this technology. Recent advancements in the field of 3D printing technology used in the pharmaceutical industry mainly focused on different techniques for the fabrication of different dosage forms. The Food and Drug Administration's (FDA) recent approval of the first 3D prescription highlights possibilities for 3D printing innovation in the pharmaceutical drug supply field. This analysis assesses 3D printing advancement possibilities, particularly in the area of custom prescriptions. This technology can be regarded as the future of demand-produced, low-cost solid dosage forms, and helps minimize side effects due to overdose.

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