Evaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and d-panthenyl triacetate as combinational treatment

2021 ◽  
Vol 26 (4) ◽  
pp. 444-454
Author(s):  
Ali Asram Sağıroğlu ◽  
Burak Çelik ◽  
Eray Metin Güler ◽  
Abdurrahim Koçyiğit ◽  
Özgen Özer
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10 ◽  
Combinational Treatment

scholarly journals Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 332 ◽  
Author(s):  
Kyeong-A Ryu ◽  
Phil June Park ◽  
Seong-Bo Kim ◽  
Bum-Ho Bin ◽  
Dong-Jin Jang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10 ◽  
Topical Administration ◽  
Therapeutic Agents ◽  
Ternary Diagram ◽  
Isopropyl Myristate ◽  
Microemulsion System ◽  
Cremophor El ◽  
Wound Healing Effect ◽  
20 Nm

The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL®, and Transcutol® HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (w/w %) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (w/w %). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL®, and Transcutol® HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin.

Effects of topical Coenzyme Q10, Xanthan Gum and Sodium Hyaluronate on corneal epithelial wound healing

2021 ◽  
pp. 1-7
Author(s):  
Leyla Asena ◽  
Gülşah Gökgöz ◽  
Fatma Helvacıoğlu ◽  
Gonca Özgün ◽  
Emine Ebru Deniz ◽  
...  
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10 ◽  
Xanthan Gum ◽  
Sodium Hyaluronate ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

scholarly journals The Topical Effect of Coenzyme Q10 on Wound Healing in Mice

2018 ◽  
Vol 19 (1) ◽  
pp. 42-51
Author(s):  
Ibtisam Al-Jureisy ◽  
Wael Al-Wattar ◽  
Ghada Taqa
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10

The effect of topical and subconjunctival coenzyme q10 on wound healing modulation in an experimental trabeculectomy model

2021 ◽  
Vol 16 (2) ◽  
pp. 122
Author(s):  
Çağlar Bektaş ◽  
Hatice Tuba Atalay ◽  
Cemile Merve Seymen ◽  
Nilay Dilekmen ◽  
Zeynep Aktaş ◽  
...  
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10

scholarly journals Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats

Nutrients ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 5756-5769 ◽  
Author(s):  
Toshiki Yoneda ◽  
Takaaki Tomofuji ◽  
Yuya Kawabata ◽  
Daisuke Ekuni ◽  
Tetsuji Azuma ◽  
...  
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Coenzyme Q10 ◽  
Tooth Extraction

scholarly journals Superpulsed 904 nm laser photobiomodulation combined with coenzyme Q10 synergistically augment burn wound healing

2021 ◽  
pp. 100053
Author(s):  
Anju Yadav ◽  
Ashok Priyadarshi ◽  
Gaurav K. Keshri ◽  
Saurabh Verma ◽  
Asheesh Gupta
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10 ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals The Topical Effect of Coenzyme Q10 on Wound Healing in Mice

2018 ◽  
Vol 19 (1) ◽  
pp. 42-51
Author(s):  
Ibtisam Al-Jureisy ◽  
Wael Al-Wattar ◽  
Ghada Taqa
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10

scholarly journals Effects of coenzyme Q10 encapsulated in nanoliposomes on wound healing processes after tooth extraction

2018 ◽  
Vol 13 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Kosta Todorovic ◽  
Goran Jovanovic ◽  
Ana Todorovic ◽  
Aleksandar Mitic ◽  
Nenad Stojiljkovic ◽  
...  
Keyword(s):  
Wound Healing ◽  
Coenzyme Q10 ◽  
Tooth Extraction ◽  
Healing Processes

ultrastructural process of intestinal wound healing

1995 ◽  
Vol 53 ◽  
pp. 1024-1025
Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp
Keyword(s):  
Wound Healing ◽  
Epithelial Cells ◽  
Smooth Muscles ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Ileal Mucosa ◽  
Wound Model ◽  
Serosal Surface ◽  
Complex Process ◽  
Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell
Keyword(s):  
Wound Healing ◽  
Liver Disease ◽  
Hepatic Fibrosis ◽  
Cell Activation ◽  
Stellate Cell ◽  
Factor Xa ◽  
Clinical Trial Data ◽  
Chronic Liver ◽  
Healing Response ◽  
Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

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