Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats

Abstract Purpose To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment? Methods After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included. Results 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing. Conclusions Based on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.

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Beneficial Effects of Curcumin on the Wound-healing Process after Tooth Extraction

Natural Product Communications ◽

10.1177/1934578x1701201223 ◽

2017 ◽

Vol 12 (12) ◽

pp. 1934578X1701201 ◽

Cited By ~ 2

Author(s):

Aleksandar Mitic ◽

Kosta Todorovic ◽

Nenad Stojiljkovic ◽

Nikola Stojanovic ◽

Sonja Ilic ◽

...

Keyword(s):

Nitric Oxide ◽

Wound Healing ◽

Soft Tissue ◽

Tooth Extraction ◽

Healing Process ◽

Microscopic Analysis ◽

Wound Healing Process ◽

Polymorphonuclear Cells ◽

Myeloperoxidase Activity ◽

Collagen Deposition

This study evaluated the effects of curcumin, a naturally occurring compound with numerous health-beneficial properties, on the wound-healing process of extraction sockets (soft tissue that surrounded the extracted tooth) in rats. The effects of topically applied curcumin were monitored by tracking changes in myeloperoxidase activity and nitric oxide concentrations in soft tissue homogenates 3 and 7 days following surgery. Additionally, pathohistological examination of tissue sections was used to reveal the effects of curcumin on the course of wound healing on a microscopic level. Compared to the untreated control, topically administered curcumin statistically significantly decreased soft-tissue myeloperoxidase activity and nitric oxide concentrations after both 3 and 7 days of application. Microscopic analysis showed a reduced inflammatory infiltrate (subjectively and morphometrically estimated as the number of polymorphonuclear cells/100 μm2) and an increased collagen deposition in rats treated with curcumin. The obtained results point to the great potential of curcumin in the acceleration of tooth extraction wound-healing processes partially through the reduction of the inflammatory response and increase in collagen deposition. Thus, these results significantly contribute to the previously suggested application of curcumin in the skin wound treatment by potentially broadening its usage in the treatment of mucosal wounds.

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Effects of coenzyme Q10 encapsulated in nanoliposomes on wound healing processes after tooth extraction

Journal of Dental Sciences ◽

10.1016/j.jds.2017.10.004 ◽

2018 ◽

Vol 13 (2) ◽

pp. 103-108 ◽

Cited By ~ 2

Author(s):

Kosta Todorovic ◽

Goran Jovanovic ◽

Ana Todorovic ◽

Aleksandar Mitic ◽

Nenad Stojiljkovic ◽

...

Keyword(s):

Wound Healing ◽

Coenzyme Q10 ◽

Tooth Extraction ◽

Healing Processes

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Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implication in Fracture Repair and Wound Healing in Humans

10.21236/ada482393 ◽

2008 ◽

Author(s):

Subburaman Mohan

Keyword(s):

Wound Healing ◽

Soft Tissue ◽

Bone Formation ◽

Tissue Regeneration ◽

Molecular Mechanisms ◽

Fracture Repair ◽

Soft Tissue Regeneration

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Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

International Journal of Molecular Sciences ◽

10.3390/ijms22041538 ◽

2021 ◽

Vol 22 (4) ◽

pp. 1538 ◽

Cited By ~ 2

Author(s):

Pietro Gentile ◽

Simone Garcovich

Keyword(s):

Systematic Review ◽

Stem Cells ◽

Wound Healing ◽

Soft Tissue ◽

Chronic Wounds ◽

Platelet Rich Plasma ◽

Skin Wounds ◽

Soft Tissue Defects ◽

Chronic Skin ◽

Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

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Immediate Loading of Single Post-Extractive Implants in the Anterior Maxilla: 12-Month Results From a Multicenter Clinical Study

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-11-00058 ◽

2012 ◽

Vol 38 (S1) ◽

pp. 477-484 ◽

Cited By ~ 4

Author(s):

Tommaso Grandi ◽

Giovanna Garuti ◽

Rawad Samarani ◽

Paolo Guazzi ◽

Andrea Forabosco

Keyword(s):

Clinical Study ◽

Soft Tissue ◽

Bone Resorption ◽

Tooth Extraction ◽

Immediate Loading ◽

Insertion Torque ◽

Anterior Maxilla ◽

Implant Placement ◽

Implant Size ◽

Multicenter Clinical Study

The purpose of the study was to evaluate survival and peri-implant bone levels of single, immediately loaded post-extractive implants in the anterior maxilla 12 months after implant placement. Thirty-six consecutive patients from 3 study centers were included in the study. The concerned sites were upper premolars, canines, and incisors. For each patient the following data were recorded: reason for tooth extraction, bone quality, implant size, and final insertion torque. Implants were placed using a flapless technique and immediately loaded with a nonoccluding temporary restoration. Final restorations were provided 4 months later. Peri-implant bone resorption was evaluated radiographically after 6 and 12 months. The average final insertion torque was 70.55 Ncm. One implant inserted in D3 quality bone with a 35-Ncm seating torque was lost. All other implants had a final insertion torque ranging between 50 and 80 Ncm. The average peri-implant bone loss was 0.437 and 0.507 mm at 6 and 12 months, respectively. All the sites maintained excellent papillae and peri-implant soft-tissue conditions. The resulting 1-year success rate was 97.2%. Immediate nonfunctional loading of single post-extractive implants in the anterior maxilla is a predictable treatment. And it seems that achieving high insertion torques by placing self-tapping/self-condensing implants in an underprepared osteotomy is favorable.

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A case series of profilometric changes in two implant placement protocols at periodontally compromised non-molar sites

Scientific Reports ◽

10.1038/s41598-021-81402-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kwantae Noh ◽

Daniel S. Thoma ◽

Jung-Chul Park ◽

Dong-Woon Lee ◽

Seung-Yun Shin ◽

...

Keyword(s):

Soft Tissue ◽

Tooth Extraction ◽

Case Series ◽

Tissue Level ◽

Ridge Preservation ◽

Bone Augmentation ◽

Implant Placement ◽

Alveolar Ridge Preservation ◽

Tissue Changes ◽

Facial Area

AbstractInformation regarding profilometric changes at a soft tissue level following implant placement with different protocols is insufficient. Therefore, this study aimed to comparatively investigate the profilometric tissue changes with respect to late implant placement following alveolar ridge preservation (LP/ARP) and early implantation (EP) in periodontally compromised non-molar extraction sites. Sixteen patients were randomly assigned to the following groups: implant placement 4 months post-ARP (group LP/ARP) and tooth extraction and implant placement 4–8 weeks post-extraction (group EP). Dental impressions were obtained immediately after final prosthesis insertion and at 3, 6, and 12 months. At the time of implant placement, bone augmentation was performed in the majority of the patients. Profilometric changes of the tissue contour were minimal between the final prosthesis insertion and 12 months in the mid-facial area (0.04–0.35 mm in group LP/ARP, 0.04–0.19 mm in group EP). The overall tissue volume increased in both groups (1.70 mm3 in group LP/ARP, 0.96 mm3 in group EP). In conclusion, LP/ARP and EP led to similar stability of the peri-implant tissue contour between the final prosthesis insertion and at 12 months. Moreover, the change of peri-implant tissue on the soft tissue level was minimal in both modalities.

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Proliferative Activity, Apoptosis, and Histogenesis in the Early Stages of Rat Tooth Extraction Wound Healing

Cells Tissues Organs ◽

10.1159/000103513 ◽

2007 ◽

Vol 186 (2) ◽

pp. 104-111 ◽

Cited By ~ 14

Author(s):

Hirotaka Sato ◽

Yasunori Takeda

Keyword(s):

Wound Healing ◽

Proliferative Activity ◽

Tooth Extraction ◽

Early Stages

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Combined use of ultrasonic cavitation and vacuum therapy in compiex treatments of acute puruient-necrotic processes

Bukovinian Medical Herald ◽

10.24061/2413-0737.xviii.4.72.2014.237 ◽

2014 ◽

Vol 18 (4 (72)) ◽

Author(s):

I. V. Shkvarkovkyi ◽

T. V. Antoniuk

Keyword(s):

Wound Healing ◽

Soft Tissue ◽

Ultrasonic Cavitation ◽

New Method ◽

Vacuum Therapy ◽

Combined Use

A new method for the treatment of patients with acute purulent necrotic processes by means of ultrasonic cavitation and vacuum therapy has been elaborated. The aim was to study the combined influence of ultrasonic cavitation and vacuum therapy on the course of wound healing. The method complements the treatment of patients with severe purulent necrotic processes of soft tissue.

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