scholarly journals Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains

2016 ◽  
Vol 29 (3) ◽  
pp. 164-172 ◽  
Author(s):  
Alberto Vitali ◽  
Elisabetta Vavala ◽  
Valeria Marzano ◽  
Claudia Leone ◽  
Massimo Castagnola ◽  
...  
2019 ◽  
Vol 7 (9) ◽  
pp. 310 ◽  
Author(s):  
Martin Nilsson ◽  
Michael Givskov ◽  
Svante Twetman ◽  
Tim Tolker-Nielsen

Screening of a Streptococcus mutans mutant library indicated that pgmA mutants displayed a reduced biofilm-associated tolerance toward gentamicin. The biofilms formed by the S. mutans pgmA mutant also displayed decreased tolerance towards linezolid and vancomycin compared to wild-type biofilms. On the contrary, the resistance of planktonic S. mutans pgmA cells to gentamycin, linezolid, and vancomycin was more similar to wild-type levels. Investigations of biofilms grown in microtiter trays and on submerged glass slides showed that pgmA mutants formed roughly the same amount of biofilm as the wild type, indicating that the reduced antimicrobial tolerance of these mutants is not due to diminished biofilm formation. The pgmA gene product is known to be involved in the synthesis of precursors for cell wall components such as teichoic acids and membrane glycolipids. Accordingly, the S. mutans pgmA mutant showed increased sensitivity to Congo Red, indicating that it has impaired cell wall integrity. A changed cell wall composition of the S. mutans pgmA mutant may play a role in the increased sensitivity of S. mutans pgmA biofilms toward antibiotics.


2007 ◽  
Vol 98 (16) ◽  
pp. 2985-2992 ◽  
Author(s):  
Gautam Sarath ◽  
Lisa M. Baird ◽  
Kenneth P. Vogel ◽  
Robert B. Mitchell

Author(s):  
Eliza Louback ◽  
Diego Silva Batista ◽  
Tiago Augusto Rodrigues Pereira ◽  
Talita Cristina Mamedes-Rodrigues ◽  
Tatiane Dulcineia Silva ◽  
...  

2015 ◽  
Vol 8 (3) ◽  
pp. 1352-1361 ◽  
Author(s):  
Aaron J. Sindelar ◽  
Craig C. Sheaffer ◽  
John A. Lamb ◽  
Hans-Joachim G. Jung ◽  
Carl J. Rosen

2006 ◽  
Vol 38 (3-5) ◽  
pp. 180-190 ◽  
Author(s):  
Renato Bochicchio ◽  
Carmen L.O. Petkowicz ◽  
Iedo Alquini ◽  
Ana P. Busato ◽  
Fany Reicher

1972 ◽  
Vol 18 (7) ◽  
pp. 1168-1170 ◽  
Author(s):  
C. R. MacKenzie ◽  
D. C. Jordan

Mutation to viomycin-resistance in Rhizobium meliloti R21 resulted in an accumulation of phosphatidylcholine and phosphatidylethanolamine in the cell wall. Resistance to viomycin decreased when the excess lipid was removed by EDTA or when its synthesis was prevented by growth of normally resistant cells at 40 °C. Microelectrophoretic data showed binding of viomycin to the cell surface and it is proposed that the mechanism of resistance to viomycin is an immobilization of the antibiotic in the surface layers of the cell as a result of combination with phospholipid.


2009 ◽  
Vol 114 (3) ◽  
pp. 1042-1049 ◽  
Author(s):  
Catherine M.G.C. Renard ◽  
C. Ginies

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