Voriconazole pharmacokinetics in a critically ill patient during extracorporeal membrane oxygenation

2021 ◽  
pp. 1-5
Author(s):  
Xiao-bin Lin ◽  
Xiao-guang Hu ◽  
Yan-zhe Xia ◽  
Xiao-man Liu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Critically Ill Patient ◽  
Membrane Oxygenation

scholarly journals Management of a COVID-19-infected critically ill patient treated by extracorporeal membrane oxygenation: a case report

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Qingpin Fu ◽  
Difei Li ◽  
Wei He ◽  
Qiuxuan Zeng ◽  
Jieya Chen ◽  
...  
Keyword(s):  
Case Report ◽  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Critically Ill Patient ◽  
Membrane Oxygenation

scholarly journals Critically Ill Patients With H1N1 Influenza A Undergoing Extracorporeal Membrane Oxygenation

2011 ◽  
Vol 31 (5) ◽  
pp. e8-e24 ◽  
Author(s):  
Christopher Bibro ◽  
Christine Lasich ◽  
Frank Rickman ◽  
Nichole E. Foley ◽  
Sujen K. Kunugiyama ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Health Care Team ◽  
Swine Flu ◽  
Standards Of Care ◽  
Critically Ill Patient ◽  
Membrane Oxygenation

The most common cause of death due to the H1N1 subtype of influenza A virus (swine flu) in the 2009 to 2010 epidemic was severe acute respiratory failure that persisted despite advanced mechanical ventilation strategies. Extracorporeal membrane oxygenation (ECMO) was used as a salvage therapy for patients refractory to traditional treatment. At Legacy Emanuel Hospital, Portland, Oregon, the epidemic resulted in a critical care staffing crisis. Among the 15 patients with H1N1 influenza A treated with ECMO, 4 patients received the therapy simultaneously. The role of ECMO in supporting patients with severe respiratory failure due to H1N1 influenza is described, followed by discussions of the nursing care challenges for each body system. Variations from standards of care, operational considerations regarding staff workload, institutional burden, and emotional wear and tear of the therapy on patients, patients’ family members, and the entire health care team are also addressed. Areas for improvement for providing care of the critically ill patient requiring ECMO are highlighted in the conclusion.

scholarly journals Recovery from respiratory failure after 49-day extracorporeal membrane oxygenation support in a critically ill patient with COVID-19: case report

2020 ◽  
Author(s):  
Fengwei Guo ◽  
Chao Deng ◽  
Tao Shi ◽  
Yang Yan
Keyword(s):  
Respiratory Failure ◽  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Life Support ◽  
Critically Ill Patient ◽  
Hypoxemic Respiratory Failure ◽  
Plasma Therapy ◽  
Form Of Life ◽  
Membrane Oxygenation ◽  
Life Threatening

Abstract Background Respiratory failure is a life-threatening complication of coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. Extracorporeal membrane oxygenation (ECMO) in COVID-19 might offer promise based on our clinical experience. However, few critically ill cases with COVID-19 have been weaned off ECMO. Case summary A 66-year-old Chinese woman presented with fever (38.9°C), cough, dyspnoea, and headache. She had lymphopenia (0.72 × 109/L) and computed tomography findings of ground-glass opacities. Subsequently, she was confirmed to have respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. She was intubated after transfer to the intensive care unit due to respiratory failure and heart failure. However, her condition continued to deteriorate rapidly. Veno-veno ECMO was undertaken for respiratory and cardiac support due to refractory hypoxemic respiratory failure and bradyarrhythmia (45 b.p.m.). During hospitalization, she was also administered anti-viral treatment, convalescent plasma therapy, and continuous renal replacement therapy. She was maintained on ECMO before she had fully recovered from the condition that necessitated ECMO use and had a negative test for the nucleic acids of SARS-CoV-2 twice. Forty-nine days later, this patient was weaned from ECMO. At the most recent follow-up visit (3 months after weaning from ECMO), she received respiratory and cardiac rehabilitation and did not complain of any discomfort. Discussion As far as we know, the longest duration of ECMO treatment in this critical case with COVID-19 is supportive of ECMO as the most aggressive form of life support and the last line of defence during the COVID-19 epidemic.

P1713Predictors of mortality following extracorporeal membrane oxygenation support in a large unselected critically ill patient population

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
B T Nemeth ◽  
I F Edes ◽  
I Hartyanszky ◽  
B Szilveszter ◽  
L Fazekas ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Patient Population ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Critically Ill Patient ◽  
Ventricular Ejection Fraction ◽  
Membrane Oxygenation ◽  
Va Ecmo

Abstract Background Mechanical circulatory support (MCS) has been established as a means of augmenting circulation in critically ill patients due to a variety of underlying clinical reasons. Different methods of MCS may be applied with the venous-arterial extracorporeal membrane oxygenation (VA-ECMO) system being one of the most utilized in everyday care. Objectives Our aim was to determine independent predictors of mortality following VA-ECMO therapy in a large, unselected, adult, critically ill patient population requiring MCS. Methods Data on 181 consecutive, real-world VA-ECMO treatments have been assessed. Analysis was conducted for all subjects requiring MCS with the VA-ECMO as first instalment, regardless of underlying cause or eventual upgrade. All potential clinical factors influencing mortality were examined and evaluated. Results Overall mortality amounted to ≈65% at a median follow-up of 28 days and depended upon: glomerular filtration rate of <60 ml/min/1.73 m2 (HR: 1.53; p=0.03) and age ≥65 years (HR: 1.65; p=0.02) based on multivariate Cox regression analysis. However, prolonged ECMO time, conversion of the ECMO to longer duration MCS, diabetes, prior ACS or revascularization, reduced left ventricular ejection fraction (EF) had no effect on adverse mortality outcomes (all p>0.05). Surprisingly, neither the need for resuscitation during MCS nor any ECMO implantation indication influenced mortality by itself (p>0.05). Conclusions We have found that mortality in critically ill patients requiring VA-ECMO use remains very high. Decreased renal function and advanced age were found to influence mortality in our all-comers patient population, while traditional predictors of cardiovascular mortality did not have a significant effect on survival.

scholarly journals Predictors of mortality following extracorporeal membrane oxygenation support in an unselected, critically ill patient population

2021 ◽  
Vol 17 (3) ◽  
pp. 290-297
Author(s):  
István Ferenc Édes ◽  
Balázs Tamás Németh ◽  
István Hartyánszky ◽  
Bálint Szilveszter ◽  
Péter Kulyassa ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Patient Population ◽  
Critically Ill Patient ◽  
Predictors Of Mortality ◽  
Membrane Oxygenation

Use of an Extracorporeal Membrane Oxygenation Circuit as a Bridge to Salvage a Major Upper-Extremity Replant in a Critically Ill Patient

2010 ◽  
Vol 26 (08) ◽  
pp. 517-522 ◽  
Author(s):  
Patrick Greaney ◽  
Michael Cordisco ◽  
Daniel Rodriguez ◽  
Jordanna Newberger ◽  
Alan Legatt ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Upper Extremity ◽  
Critically Ill ◽  
Critically Ill Patient ◽  
Membrane Oxygenation

Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Adults During Extracorporeal Membrane Oxygenation: A Systematic Review

Drugs ◽  
2021 ◽  
Author(s):  
Marc-Alexandre Duceppe ◽  
Salmaan Kanji ◽  
Anh Thu Do ◽  
Ni Ruo ◽  
Yiorgos Alexandros Cavayas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Extracorporeal Membrane Oxygenation ◽  
Critically Ill ◽  
Membrane Oxygenation ◽  
Critically Ill Adults ◽  
Ill Adults
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