scholarly journals Serum and sputum MMP-9/TIMP-1 in winter sports athletes and swimmers: relationships with airway function.

Biomarkers ◽  
2021 ◽  
pp. 1-29
Author(s):  
Valérie Bougault ◽  
Julie Turmel ◽  
Louis-Philippe Boulet
2021 ◽  
Author(s):  
Valérie Bougault ◽  
Julie Turmel ◽  
Louis-Philippe Boulet

AbstractIntroductionCompetitive cross-country skiers and swimmers present characteristics of airway inflammation and remodeling of the extracellular matrix similar to what is observed in mild asthma. We aimed to compare serum and sputum MMP-9/TIMP-1, reflecting the balance between airway fibrogenesis and inflammation process, in swimmers and winter sport athletes, during the annual period of training resumption, and to observe its seasonal variations in winter sports athletes.MethodsCompetitive winter sports athletes (n=41), swimmers (n=25) and healthy nonathletes (n=8) had blood sampling, lung function measurement, skin prick tests, eucapnic voluntary hyperpnea challenge, methacholine inhalation test (MIT), and induced sputum analysis. Twelve winter sport athletes performed the test during both summer and winter. Serum and sputum MMP-9 and TIMP-1 were measured by ELISA.ResultsNo significant difference in baseline serum or sputum MMP-9/TIMP-1 ratio was observed between the three groups, and no relationship was observed with airway function or responsiveness. Serum MMP-9/TIMP-1 ratio was however significantly higher during the summer in winter sport athletes compared with winter season (median [Interquartile range]: 1.27 [0.97-1.62] during the winter and 3.65 [2.47-4.03] during the summer, p=0.005). Sputum MMP-9 correlated with Methacholine PC20 and serum CC16/SP-D ratio. No significant correlation was observed between serum values and lung function or responsiveness.ConclusionOur results suggest that although MMP-9/TIMP-1 ratio in sputum or serum was similar in our three groups of subjects, it may fluctuate according to the training season while sputum MMP-9 correlated with Methacholine PC20 and serum CC16/SP-D ratio, suggesting a link between airway responsiveness, epithelial damage and MMP-9 in the airways.


2020 ◽  
Vol 103 (11) ◽  
pp. 1116-1120

Background: The systematic surveillance of injuries and illness in young athletes is important to reduce the loss of training and competition time and enable continuing sports participation. However, the risk and incidence of injury and illness in tropical country athletes competing in winter sports remains unclear. Objective: To identify the incidence, severity, and causes of injuries and illness in the Thailand National Youth Team during the 10-day First Winter Children of Asia Games. Materials and Methods: In the present observational prospective cohort study, the authors used the International Olympic Committee (IOC) injury and illness surveillance system for multisport events. The injuries and illnesses of 18 Thailand athletes were collected daily by the team physician over a 10-day competition period. Results: Eight injuries and nine illnesses were reported, equating to 44.4% of the athletes sustaining at least one injury and 50% at least one illness, an incidence rate of 2.6 injuries and 7.3 illnesses per 100 athletes, respectively. The risk of sustaining an injury was highest during cross country skiing while the most common type of injury was a sprain. The upper respiratory tract was the site most affected by illness with females reporting a greater illness rate. Conclusion: The presented data constitute the basis for future analyses of injury and illness associated risk factors in winter sports, which are essential to develop and implement effective preventative strategies in tropical winter sport athletes. Keywords: Surveillance, Injury and illness, Winter sport


2018 ◽  
Author(s):  
Stefania Barbieri ◽  
Elisa Bertoldi ◽  
Giulia Maria Cillo ◽  
Rosa Maria Gaudio ◽  
Rossella Snenghi ◽  
...  

BACKGROUND Helmet use is now viewed as an essential safety measure in almost all sports involving a high risk of impact and head trauma, from horseback riding to mountain biking, rock climbing and winter sports such as skiing and snowboarding. For young skiers and snowboarders under the age of 14, the use of certified helmets is compulsory in Italian law, although no defined regulations exist for recreational sledding OBJECTIVE To review past and current regulations covering winter sports, to explore potential legal discrepancies in appraising factors related to helmet use in recreational activities by children under the age of 14, and to identify hazards connected with various types of sledding accidents METHODS Descriptive data of the cases of 16-year-old or younger adolescents injured while sledding without helmets were gathered from injury reports collected by ski patrols, pre-hospital emergency services and emergency departments, and compared with 53 cases of adolescents and children who went skiing and snowboarding wearing certified helmets, over two winter seasons (December to April, 2011-12 and 2012-13). Sledges were grouped into three categories:1) traditional wooden toboggans (hereafter called ‘traditional sleds’); 2) plastic sleds; 3) newly designed sleds (with inner tubes, plastic and hard foam sleds, snowskates, boardslides, runslides, snowblades, foam slides, etc.) RESULTS Descriptive data of the cases of 16-year-old or younger adolescents injured while sledding without helmets were gathered from injury reports collected by ski patrols, pre-hospital emergency services and emergency departments, and compared with 53 cases of adolescents and children who went skiing and snowboarding wearing certified helmets, over two winter seasons (December to April, 2011-12 and 2012-13). Sledges were grouped into three categories:1) traditional wooden toboggans (hereafter called ‘traditional sleds’); 2) plastic sleds; 3) newly designed sleds (with inner tubes, plastic and hard foam sleds, snowskates, boardslides, runslides, snowblades, foam slides, etc.) CONCLUSIONS Additional investigation of the actual dynamics of the accident, together with information on the sitting position and sled speed are required. Regulations should compel ski slope operators to improve the current level of control on sledding slopes.


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