Scaling head-neck response data and derivation of 5th percentile female side-impact dummy head-neck response requirements in NBDL test conditions

2009 ◽  
Vol 14 (3) ◽  
pp. 233-243 ◽  
Author(s):  
Riske Meijer ◽  
Robbert Wisgerhof ◽  
Jac Wismans ◽  
Bernard Been
Keyword(s):  
Side Impact ◽  
Female Side ◽  
Response Data ◽  
Test Conditions ◽  
Head Neck

scholarly journals Design and Evaluation of the Initial 50th Percentile Female Prototype Rear Impact Dummy, BioRID P50F – Indications for the Need of an Additional Dummy Size

2021 ◽  
Vol 9 ◽  
Author(s):  
Anna Carlsson ◽  
Johan Davidsson ◽  
Astrid Linder ◽  
Mats Y. Svensson
Keyword(s):  
Angular Displacement ◽  
Crash Test ◽  
Head Restraint ◽  
Response Data ◽  
Rear Impact ◽  
Protection Systems ◽  
Crash Test Dummy ◽  
Rear Impacts ◽  
Lumbar Spinal ◽  
Head Neck

The objective of this study was to present the design of a prototype rear impact crash test dummy, representing a 50th percentile female, and compare its performance to volunteer response data. The intention was to develop a first crude prototype as a first step toward a future biofidelic 50th percentile female rear impact dummy. The current rear impact crash test dummy, BioRID II, represents a 50th percentile male, which may limit the assessment and development of whiplash protection systems with regard to female occupants. Introduction of this new dummy size will facilitate evaluation of seat and head restraint (HR) responses in both the average sized female and male in rear impacts. A 50th percentile female rear impact prototype dummy, the BioRID P50F, was developed from modified body segments originating from the BioRID II. The mass and rough dimensions of the BioRID P50F is representative of a 50th percentile female. The prototype dummy was evaluated against low severity rear impact sled tests comprising six female volunteers closely resembling a 50th percentile female with regard to stature and mass. The head/neck response of the BioRID P50F prototype resembled the female volunteer response corridors. The stiffness of the thoracic and lumbar spinal joints remained the same as the average sized male BioRID II, and therefore likely stiffer than joints of an average female. Consequently, the peak rearward angular displacement of the head and T1, and the rearward displacement of the T1, were lesser for the BioRID P50F in comparison to the female volunteers. The biofidelity of the BioRID P50F prototype thus has some limitations. Based on a seat response comparison between the BioRID P50F and the BioRID II, it can be concluded that the male BioRID II is an insufficient representation of the average female in the assessment of the dynamic seat response and effectiveness of whiplash protection systems.

Application of CAP to Analyze Mechanisms Producing Dummy Injury Readings under U.S. Side Impact Test Conditions

2011 ◽  
Author(s):  
Yuji Fujiyama ◽  
Daisuke Sonoyama ◽  
Kazuhiro Obayashi ◽  
Qiang Yu PhD
Keyword(s):  
Impact Test ◽  
Side Impact ◽  
Test Conditions

Influence of Test Conditions on Protection Criteria in Side Impact

1996 ◽  
Author(s):  
Pascal Baudrit ◽  
Alain Dômont ◽  
Xavier Trosseille ◽  
Claude Terrière
Keyword(s):  
Side Impact ◽  
Test Conditions

SID Response Data in a Side Impact Sled Test Series

1992 ◽  
Author(s):  
John M. Cavanaugh ◽  
Yue Huang ◽  
Ronald J. Wasko ◽  
Albert I. King
Keyword(s):  
Side Impact ◽  
Test Series ◽  
Sled Test ◽  
Response Data

WorldSID small female side impact dummy pelvis linear guided mass impactor tests

2007 ◽  
Vol 10 (sup1) ◽  
pp. 75-76
Author(s):  
F. Bermond ◽  
Y. Caire ◽  
P. Vezin ◽  
J.-P. Verriest
Keyword(s):  
Side Impact ◽  
Female Side ◽  
Small Female

Randomized, phase III trial comparing liposomal platin with cisplatin in patients (pts) with advanced squamous cell carcinoma of the head & neck (SCCHN) regarding safety and efficacy profiles

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 5564-5564
Author(s):  
D. Luftner ◽  
S. Siepmann ◽  
J. Christian ◽  
D. Pollmann ◽  
G. Pecher ◽  
...  
Keyword(s):  
Renal Toxicity ◽  
Phase Iii ◽  
Hematological Toxicity ◽  
Phase Iii Trial ◽  
Safety And Efficacy ◽  
Response Data ◽  
First Response ◽  
Increased Risk ◽  
Head Neck ◽  
Grade Iii

5564 Background: Based on a metanalysis of > 16,000 patients (Bourhis, ASCO 2004), cisplatin emerges as the essential agent for the treatment of advanced SCCHN. However, its clinical use is impeded by its severe adverse reactions, as renal toxicity. In a randomized, phase III trial we replaced conventional cisplatin by a liposomal formulation of cisplatin (lipoplatin) and compared the safety and efficacy profiles. Methods: The study was designed for two treatment arms: A: 100 mg/m2/d lipoplatin (d 1,8,15) plus 1,000 mg/m2/d 5-FU (d 1–5) q3w for 6 cycles; B: 100 mg/m2/d cisplatin (d 1) plus 1000 mg/m2/d 5-FU (d 1–5) q3w for 6 cycles. Main inclusion criteria selected pts with primary metastatic, relapsed or progressive SCCHN between 18–75 years and creatinin clearance >50ml/min. Main endpoints for this interims analysis were hemato- and nephrotoxicity. First response data were collected. The study was designed for non-inferiority. Results: Out of 41 randomized pts, 30 pts are evaluable for toxicity (15 pts for every arm) and 27 pts (15 pts for lipoplatin, 12 pts for cisplatin) for outcome. In the cisplatin arm hematotoxicity was more frequent (leucopenia grade I/II: 5 pts, grade III/IV: 3 and 1 pts vs 5 pts with grade I/II in the lipoplatin arm). The rate of anemia was similar between the treatment arms. A total of 11 pts in the lipoplatin arm experienced renal toxicity grade I/II as measured by a reduction of the creatinine clearance and 12 pts in the cisplatin arm (grade I/II: 7 pts; grade III: 5 pts). No renal toxicity grade III was developed in the lipoplatin arm until now. Outcome was as follows: lipoplatin arm: PR: 1 pt; SD: 6 pts; PD: 8 pts; cisplatin arm: PR: 7 pts; SD: 3 pts; PD: 2 pts. Thus, the non-PD pts (PR or SD) is 7/15 (47%) in the lipoplatin arm vs 10/12 (83%) cases in the cisplatin arm. Conclusions: Liposomal platin seems to reduce both the hematological and non-hematological toxicity profiles as compared to conventional cisplatin to a clinically relevant extent. As patients with advanced SCCHN have an increased risk of renal toxicity due to poor hydration, the observed reduction of side effects will influence the chance to preserve the dose density of chemotherapy, and thereby, the efficacy of treatment. No significant financial relationships to disclose.

Effects of Fundamental Frequency Contours on Sentence Recognition in Mandarin-Speaking Children With Cochlear Implants

2020 ◽  
Vol 63 (11) ◽  
pp. 3855-3864
Author(s):  
Wanting Huang ◽  
Lena L. N. Wong ◽  
Fei Chen ◽  
Haihong Liu ◽  
Wei Liang
Keyword(s):  
Cochlear Implants ◽  
Fundamental Frequency ◽  
Signal To Noise Ratio ◽  
Lexical Tone ◽  
Signal To Noise ◽  
Sentence Recognition ◽  
Test Conditions ◽  
Age Appropriate ◽  
F0 Contour ◽  
Appropriate Sentences

Purpose Fundamental frequency (F0) is the primary acoustic cue for lexical tone perception in tonal languages but is processed in a limited way in cochlear implant (CI) systems. The aim of this study was to evaluate the importance of F0 contours in sentence recognition in Mandarin-speaking children with CIs and find out whether it is similar to/different from that in age-matched normal-hearing (NH) peers. Method Age-appropriate sentences, with F0 contours manipulated to be either natural or flattened, were randomly presented to preschool children with CIs and their age-matched peers with NH under three test conditions: in quiet, in white noise, and with competing sentences at 0 dB signal-to-noise ratio. Results The neutralization of F0 contours resulted in a significant reduction in sentence recognition. While this was seen only in noise conditions among NH children, it was observed throughout all test conditions among children with CIs. Moreover, the F0 contour-induced accuracy reduction ratios (i.e., the reduction in sentence recognition resulting from the neutralization of F0 contours compared to the normal F0 condition) were significantly greater in children with CIs than in NH children in all test conditions. Conclusions F0 contours play a major role in sentence recognition in both quiet and noise among pediatric implantees, and the contribution of the F0 contour is even more salient than that in age-matched NH children. These results also suggest that there may be differences between children with CIs and NH children in how F0 contours are processed.

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