CANCERA winning combinationAndrogen receptor antagonists compromise the T cell response against prostate cancer, leading to early tumor relapse.Y. Pu, M. Xu, Y. Liang, K. Yang, Y. Guo, X. Yang, Y.-X. Fu, Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse. Sci. Transl. Med.8, 333ra47 (2016). [Abstract]NEUROTOXICITYInsights into neuronal cell deathA method to culture human cortical neurons that yielded a balanced network of excitatory and inhibitory neurons revealed that these cells die in a PARP-dependent manner after neurotoxic insult.J.-C. Xu, J. Fan, X. Wang, S. M. Eacker, T.-I. Kam, L. Chen, X. Yin, J. Zhu, Z. Chi, H. Jiang, R. Chen, T. M. Dawson, V. L. Dawson, Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci. Transl. Med.8, 333ra48 (2016). [Abstract]ATHEROSCLEROSISDissolving away cholesterolThe cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin facilitates atheroprotective mechanisms through oxysterol-mediated reprogramming of macrophages.S. Zimmer, A. Grebe, S. S. Bakke, N. Bode, B. Halvorsen, T. Ulas, M. Skjelland, D. De Nardo, L. I. Labzin, A. Kerksiek, C. Hempel, M. T. Heneka, V. Hawxhurst, M. L. Fitzgerald, J. Trebicka, I. Björkhem, J.-Å. Gustafsson, M. Westerterp, A. R. Tall, S. D. Wright, T. Espevik, J. L. Schultze, G. Nickenig, D. Lütjohann, E. Latz, Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sci. Transl. Med. 8, 333ra50 (2016). [Abstract]
Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists
