Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors

Penghambat alfa amilase adalah salah satu komponen dalam suplemen makanan yang telah lama digunakan untuk terapi kegemukan karena penghambat amilase mempengaruhi metabolisme karbohidrat dalam sistem pencernaan. Sejumlah peneliti melaporkan terdapat dua grup penghambat amilase, yaitu protein dan non protein. Penghambat protein dilaporkan terdapat dalam kelompok kacang-kacangan dan biji-bijian. Tujuan penelitian ini adalah untuk mengisolasi penghambat protein yang terdapat dalam kacang hijau dan kedele. Kacang hijau dan kedele merupakan kacang-kacangan yang penting dalam makanan popular di Indonesia. Penghambat protein diendapkan dengan konsentrasi bertingkat garam ammonium sulfat [(NH)4SO4] dari 30-70%. Penghambat protein diuji terhadap amilase saliva manusia (HSA) danamilase pankreas babi (PPA), serta kestabilannya terhadap pemanasan pada 100oC selama 30 menit. Hasil penelitian menunjukkan bahwa semua endapan jenuh dari semua konsentrasi amonium sulfat yang diuji menghambat PPA, tetapi tidak semua endapan jenuh tersebut dapatmenghambat HSA. Hanya semua endapan jenuh (NH)4SO4 dari kacang hijau yang dapat menghambat HSA, dan penghambatan tertinggi terhadap HSA adalah endapan jenuh (NH)4SO4 50%. Endapan jenuh (NH)4SO4 40 % dari kedele putih dan endapan jenuh (NH)4SO4 60% dari kedele hitam dengan masing-masing penghambatan 98.67; 26.86 and27.63%. Endapan jenuh (NH)4SO4 60-70% dari kacang hijau, 50% dari kedele putih dan 50% dari kedele hitam menghambat PPA 100%. Pemanasan penghambat pada 100oC selama 30 menit hampir tidak mempengaruhi penghambatannya terhadap PPA. Profil protein juga diamati menggunakan analisis SDS/PAGE.

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Isolation, structure elucidation and quantitative analysis of callicarpone and oleanolic acid in the leaves of Callicarpa candicans collected from different provinces in Thailand

Agriculture and Natural Resources ◽

10.34044/j.anres.2019.53.3.06 ◽

2019 ◽

Keyword(s):

Quantitative Analysis ◽

Oleanolic Acid ◽

Structure Elucidation

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Inhibiting Effect of Oleanolic Acid on Ovarian Carcinomas IGROV1 and Breast Cancer Cell Line MDA-MB-231

Chinese Journal of Appplied Environmental Biology ◽

10.3724/sp.j.1145.2010.00202 ◽

2010 ◽

Vol 16 (2) ◽

pp. 202-204

Author(s):

Linwei WU ◽

Qiang PU ◽

Xiaozhen CHEN ◽

Kaize HE

Keyword(s):

Breast Cancer ◽

Cell Line ◽

Oleanolic Acid ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Breast Cancer Cell Line ◽

Cancer Cell Line ◽

Ovarian Carcinomas ◽

Inhibiting Effect

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Effects of Oleanolic Acid and Hederagenin on Acute Alcohol-Induced Hepatotoxicity in Mice

Journal of the Korean Society of Food Science and Nutrition ◽

10.3746/jkfn.2016.45.3.307 ◽

2016 ◽

Vol 45 (3) ◽

pp. 307-312

Author(s):

Suhan Jung ◽

Sanghoon Lee ◽

Kwang Suk Ko

Keyword(s):

Oleanolic Acid

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New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives

Current Pharmaceutical Design ◽

10.2174/1381612825666191105112802 ◽

2019 ◽

Vol 25 (35) ◽

pp. 3740-3750 ◽

Cited By ~ 1

Author(s):

Ning Sun ◽

Dongli Li ◽

Xiaoqing Chen ◽

Panpan Wu ◽

Yu-Jing Lu ◽

...

Keyword(s):

Oleanolic Acid ◽

Liver Diseases ◽

Therapeutic Agent ◽

Heart Diseases ◽

Pentacyclic Triterpenoids ◽

Hepatic Drug ◽

Approved Drugs ◽

New Applications ◽

Functional Mechanisms ◽

Potent Therapeutic Agent

Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.

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