Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge

2019 ◽  
Vol 33 (22) ◽  
pp. 3784-3790 ◽  
Author(s):  
Tomas Matejek ◽  
Martina Navratilova ◽  
Lenka Zaloudkova ◽  
Jana Malakova ◽  
Jan Maly ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Vitamin D Status ◽  
Low Birth Weight Infants ◽  
Vitamin D Levels

Questioning the adequacy of standardized vitamin D supplementation protocol in very low birth weight infants: a prospective cohort study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hatice Sarıdemir ◽  
Ozge Surmeli Onay ◽  
Ozge Aydemir ◽  
Ayse Neslihan Tekin
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Prospective Cohort ◽  
Very Low Birth Weight ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Vlbw Infants ◽  
Vitamin D Levels

Abstract Objectives Preterm infants are at increased risk for vitamin D deficiency (VDD). We aimed to assess the adequacy of standardized vitamin D supplementation protocol in very low birth weight (VLBW) infants. Additionally, vitamin D status of mother/infant couples and the associations between vitamin D status at birth and morbidities of the infants were investigated. Methods In this single-center, prospective cohort study blood samples were collected from 55 mothers just before delivery and from their infants at birth and on the 30th day of life (DOL) for 25 hydroxy vitamin D (25OHD) measurements. Vitamin D was initiated in dose of 160 IU/kg by parenteral nutrition on the first DOL and oral vitamin D supplementation (400 IU/day) was administered when enteral feedings reached 50% of total intake or on the 15th DOL. Results The median 25OHD levels of the infants were 16.12 (9.14–20.50) in cord blood and 36.32 (31.10–44.44) in venous blood on the 30th DOL (p<0.01). In 98% of the VLBW infants 25OHD reached sufficient levels on the 30th DOL. None of the mothers had sufficient vitamin D levels (25OHD >30 ng/mL). Maternal 25OHD levels were correlated with the 25OHD levels of the infants in cord blood (r=0.665, p<0.001). There was a significant difference in mean cord 25OHD levels between winter (13.65 ± 5.69 ng/mL) and summer seasons (19.58 ± 11.67 ng/mL) (p=0.021). No association was found between neonatal morbidity and vitamin D status. Conclusions The results clearly show that by utilizing the current supplementation protocol, the majority of VLBW infants with deficient/insufficient serum 25OHD levels reached sufficient levels on the 30th DOL. Furthermore, vitamin D levels in mother/infant couples were found to be highly correlated.

scholarly journals Vitamin D Status of Low Birth Weight Infants in Delhi: A Comparative Study

2012 ◽  
Vol 58 (6) ◽  
pp. 446-450 ◽  
Author(s):  
R. Agarwal ◽  
D. Virmani ◽  
M. L. Jaipal ◽  
S. Gupta ◽  
N. Gupta ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Comparative Study ◽  
Vitamin D Status ◽  
Low Birth Weight Infants

Serum vitamin D metabolites in very low birth weight infants with and without rickets and fractures

1989 ◽  
Vol 114 (6) ◽  
pp. 1017-1022 ◽  
Author(s):  
Winston W.K. Koo ◽  
Roberta Sherman ◽  
Paul Succop ◽  
Mona Ho ◽  
Donna Buckley ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Serum Vitamin ◽  
Vitamin D Metabolites ◽  
Low Birth Weight Infants ◽  
Serum Vitamin D

Effect of high-dose vitamin D supplementation on radiographically detectable bone disease of very low birth weight infants

1989 ◽  
Vol 115 (5) ◽  
pp. 779-786 ◽  
Author(s):  
Jacquelyn R. Evans ◽  
Alexander C. Allen ◽  
Dora A. Stinson ◽  
David C. Hamilton ◽  
B. St. John Brown ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Bone Disease ◽  
Very Low Birth Weight ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Low Birth Weight Infants ◽  
High Dose Vitamin

Nutrient and Mineral Retention and Vitamin D Absorption in Low-Birth-Weight Infants: Effect of Medium-Chain Triglycerides

PEDIATRICS ◽  
1983 ◽  
Vol 72 (1) ◽  
pp. 44-48
Author(s):  
Robert K. Huston ◽  
John W. Reynolds ◽  
Christine Jensen ◽  
Neil R. M. Buist
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Oral Feeding ◽  
Medium Chain Triglycerides ◽  
Low Birth Weight Infants ◽  
Balance Study ◽  
Medium Chain ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

A randomized prospective study of the effect of medium-chain triglycerides (MCT) upon the absorption and retention of major minerals and nutrients, as well as upon 25-hydroxy vitamin D levels, was performed in low-birth-weight infants. Ten infants received a highcalcium and vitamin D-containing formula, which contained 50% of its fat as MCT, while ten other infants received a similar formula in which all the fat was in long-chain triglycerides. There was a five-day delay in reaching full oral feeding volumes, and therefore there was a delay in the onset of the balance study in the MCT group, primarily due to gastrointestinal symptoms. There was a significant improvement in the percent of fat absorption (P &lt; .05) with MCT, but no difference in the percent of absorption or retention of calcium, phosphorus, sodium, or nitrogen. 25-Hydroxy vitamin D levels decreased in both groups after full oral feeding volumes had been established, but all values were within normal ranges. At the high intake levels of calcium and vitamin D given to the infants, MCT did not increase major mineral or nutrient absorption.

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