A new method for preparing pentacyclic triterpene rich Centella asiatica extracts

2012 ◽  
Vol 27 (7) ◽  
pp. 684-686 ◽  
Author(s):  
Panupong Puttarak ◽  
Pharkphoom Panichayupakaranant
Keyword(s):  
Centella Asiatica ◽  
New Method ◽  
Pentacyclic Triterpene

scholarly journals Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Shyh-Shyun Huang ◽  
Chuan-Sung Chiu ◽  
Hsien-Jung Chen ◽  
Wen-Chi Hou ◽  
Ming-Jyh Sheu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Interleukin 1 ◽  
Late Phase ◽  
Centella Asiatica ◽  
Neutrophil Infiltration ◽  
Asiatic Acid ◽  
Pentacyclic Triterpene ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Oxide Synthase

Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plantCentella asiatica, was evaluated for antinociceptive and anti-inflammatory effects. Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. In the anti-inflammatory test, AA decreased the paw edema at the 4th and 5th h afterλ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue. AA decreased the nitric oxide (NO), tumor necrosis factor-α(TNF-α), and interleukin-1β(IL-1β) levels on serum level at the 5th h after Carr injection. Western blotting revealed that AA decreased Carr-induced inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and nuclear factor-κB (NF-κB) expressions at the 5th h in the edema paw. An intraperitoneal (i.p.) injection treatment with AA also diminished neutrophil infiltration into sites of inflammation as did indomethacin (Indo). The anti-inflammatory mechanisms of AA might be related to the decrease in the level of MDA, iNOS, COX-2, and NF-κB in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver.

scholarly journals Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

2012 ◽  
Vol 33 (5) ◽  
pp. 578-587 ◽  
Author(s):  
Min-fang Xu ◽  
Yu-yun Xiong ◽  
Jian-kang Liu ◽  
Jin-jun Qian ◽  
Li Zhu ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Centella Asiatica ◽  
Asiatic Acid ◽  
Pentacyclic Triterpene

Pentacyclic Triterpene Synthesis. IV a New Method for Accomplishing Robinson-Nazarov Annelations

1974 ◽  
Vol 4 (1) ◽  
pp. 71-77 ◽  
Author(s):  
John E. Ellis ◽  
John S. Dutcher ◽  
Clayton H. Heathcock
Keyword(s):  
New Method ◽  
Pentacyclic Triterpene ◽  
Triterpene Synthesis

scholarly journals Metabolitos aislados de raputia heptaphylla y esenbeckia alata (rutaceae) y síntesis de precursores de análogos de alcaloides quinolínicos

ELEMENTOS ◽  
2015 ◽  
Vol 5 (5) ◽  
Author(s):  
Carlos A. Coy Barrera ◽  
Luis E. Cuca Suárez
Keyword(s):  
Secondary Metabolites ◽  
New Method ◽  
Pentacyclic Triterpene ◽  
Chemotaxonomic Markers ◽  
First Time

<p>Abstract. Previous studies on the Esenbeckia alata and Raputia heptaphylla,</p><p>both species belonging to the Rutaceae family, have shown</p><p>important results with respect to their chemistry. These species have</p><p>secondary metabolites (coumarins and alkaloids mainly), which act as</p><p>chemotaxonomic markers. This paper presents, for the first time, the phytochemical</p><p>work and isolated metabolites in these species: four coumarins:</p><p>bergapten, xanthyletin, xanthotoxin, 3-isoprenyl-4-methoxy-coumarin;</p><p>four alkaloids: skinmianine, kokusaginine, dictamnine, and 1-methyl-2-</p><p>methoxy-4-quinolone; two lignans: sesamin and mesodihydroguaiaretic</p><p>acid; two sterols: -sitosterol, stigmasterol; and a pentacyclic triterpene:</p><p>lupeol that have been isolated from leaves of E. alata. Five alkaloids</p><p>7-methoxy-2,2-dimethyl-2,6-dihidro-piran[3,2,c] quinolin-5-one, flindersiamine,</p><p>skinmianine, kokusaginine and dictamnine that have been isolated</p><p>from leaves of R. heptaphylla. Moreover, it presents a new method by</p><p>obtaining quinolone alkaloid analogue precursors trough the condensations</p><p>of Mannich adduct vinylogous and aldehydes followed by radical</p><p>cyclization to obtain products with high regio- and stereoselectivity.</p><p> </p>

Selective Sampling and Orientation of Non-Homogeneous Tissues

1968 ◽  
Vol 26 ◽  
pp. 98-99
Author(s):  
C. C. Clawson ◽  
L. W. Anderson ◽  
R. A. Good
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Light Microscopy ◽  
Random Sampling ◽  
New Method ◽  
Microscope Examination ◽  
Small Areas ◽  
Selective Sampling ◽  
Large Numbers ◽  
Specific Orientation

Investigations which require electron microscope examination of a few specific areas of non-homogeneous tissues make random sampling of small blocks an inefficient and unrewarding procedure. Therefore, several investigators have devised methods which allow obtaining sample blocks for electron microscopy from region of tissue previously identified by light microscopy of present here techniques which make possible: 1) sampling tissue for electron microscopy from selected areas previously identified by light microscopy of relatively large pieces of tissue; 2) dehydration and embedding large numbers of individually identified blocks while keeping each one separate; 3) a new method of maintaining specific orientation of blocks during embedding; 4) special light microscopic staining or fluorescent procedures and electron microscopy on immediately adjacent small areas of tissue.

A new method for the determination of nitrates

1960 ◽  
Vol 23 ◽  
pp. 227-232 ◽  
Author(s):  
P WEST ◽  
G LYLES
Keyword(s):  
New Method
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