Postprandial glycaemia and inhibition of α-glucosidase activity by aqueous extract fromCoriandrum sativum

Diabetes mellitus is a chronic disorder that affects the metabolism of blood glucose inside the body. One of the alternative treatments is by using traditional medicinal plants, which have hypoglycemia effects. A mahogany seed is one of the traditional medicinal plants that has been proven to treat diabetes and has been used for generations. In the aqueous extract, ethanol 96 %, ethyl acetate, and hexane from mahogany seeds (Swietenia macrophylla King.) the inhibition of α-glucosidase activity are checked by measuring p-nitrophenol from p-nitrophenyl-α-D-glucopyranose (pNPG) on 400 nm. The percentage value of the inhibition for α-glucosidase ranged from 6,36-56,77 %, with 96 % ethanol extract that has the highest value and the hexane extract with the lowest value. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and triterpenoids, which could be responsible for the bioactivities shown by the 96 % ethanol extract and aqueous extract of S. macrophylla. Keywords : α-glucosidase activity, diabetes mellitus, mahogany seeds (Swietenia macrophylla King.), phytochemical screening.

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Inhibition of α-glucosidase Activity Seed Extract from Mahogany (Swietenia macrophylla King.)

Current Biochemistry ◽

10.29244/cb.6.1.5 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Waras Nurcholis ◽

Rini Muthoharoh ◽

Antonius Padua Ratu

Keyword(s):

Diabetes Mellitus ◽

Medicinal Plants ◽

Aqueous Extract ◽

Ethanol Extract ◽

The Body ◽

Phytochemical Screening ◽

Swietenia Macrophylla ◽

Glucosidase Activity ◽

Traditional Medicinal Plants ◽

Chronic Disorder

Diabetes mellitus is a chronic disorder that affects the metabolism of blood glucose inside the body. One of the alternative treatments is by using traditional medicinal plants, which have hypoglycemia effects. A mahogany seed is one of the traditional medicinal plants that has been proven to treat diabetes and has been used for generations. In the aqueous extract, ethanol 96 %, ethyl acetate, and hexane from mahogany seeds (Swietenia macrophylla King.) the inhibition of α-glucosidase activity are checked by measuring p-nitrophenol from p-nitrophenyl-α-D-glucopyranose (pNPG) on 400 nm. The percentage value of the inhibition for α-glucosidase ranged from 6,36-56,77 %, with 96 % ethanol extract that has the highest value and the hexane extract with the lowest value. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and triterpenoids, which could be responsible for the bioactivities shown by the 96 % ethanol extract and aqueous extract of S. macrophylla. Keywords : α-glucosidase activity, diabetes mellitus, mahogany seeds (Swietenia macrophylla King.), phytochemical screening.

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Inhibitory Effects of Cissus quadrangularis L. Derived Components on Lipase, Amylase and α-Glucosidase Activity in vitro

Natural Product Communications ◽

10.1177/1934578x0700200806 ◽

2007 ◽

Vol 2 (8) ◽

pp. 1934578X0700200 ◽

Cited By ~ 3

Author(s):

Hazel Sharp ◽

Jackie Hollinshead ◽

Barbara B. Bartholomew ◽

Julius Oben ◽

Alison Watson ◽

...

Keyword(s):

Enzyme Inhibition ◽

Aqueous Extract ◽

Inhibition Activity ◽

Inhibitory Effects ◽

Glucosidase Activity ◽

Cissus Quadrangularis ◽

Stems And Leaves

The stems of Cissus quadrangularis L (Vitaceae) have been consumed for centuries throughout Asia and Africa as a culinary vegetable. The aqueous extract of C. quadrangularis stems and leaves contains flavonoids and stilbenes, which inhibit lipase, amylase and α-glucosidase and, therefore, might be, at least in part, related to the claimed anti-obesity activity of the plant. The enzyme inhibition activity is outlined of a novel flavonoid (3- O-α-L-rhamnopyranosylkaempferol) (2) and stilbene (3-(4-hydroxybenzylidene)-2-(2,5-dihydroxyphenyl)-1-(4-hydroxyphenyl)indane-4,6-diol) (7), four known structurally related flavonoids, and one stilbene isolated from the extract.

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