scholarly journals The role of JNK phosphorylation as a molecular target to enhance adenovirus replication, oncolysis and cancer therapeutic efficacy

2018 ◽  
Vol 19 (12) ◽  
pp. 1174-1184 ◽  
Author(s):  
Stephen L. Wechman ◽  
Xiao-Mei Rao ◽  
Jorge G. Gomez-Gutierrez ◽  
Heshan Sam Zhou ◽  
Kelly M. McMasters
Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 876
Author(s):  
Sara Chiappalupi ◽  
Laura Salvadori ◽  
Rosario Donato ◽  
Francesca Riuzzi ◽  
Guglielmo Sorci

The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin–angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed. 


2013 ◽  
Vol 34 (suppl 1) ◽  
pp. 777-777
Author(s):  
I. Andreadou ◽  
A. Lazari ◽  
S. I. Bibli ◽  
N. Gaboriaud-Kolar ◽  
A. L. Skaltsounis ◽  
...  

Mitochondrion ◽  
2021 ◽  
Vol 56 ◽  
pp. 62-72
Author(s):  
Swati Chadha ◽  
Tapan Behl ◽  
Aayush Sehgal ◽  
Arun Kumar ◽  
Simona Bungau

Author(s):  
Turo J. Nurmikko

The landmark paper discussed in this chapter is ‘Identification of the α‎2-δ‎-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin’, published by Field et al. in 2006. In this seminal paper, Field et al. demonstrated that the anti-allodynic effect of pregabalin is related to its binding to the α‎2δ‎-1 subunit of the voltage-gated calcium channel. In transgenic mice lacking this subunit, pregabalin had no effect on allodynia induced by sciatic nerve ligation, whereas, in wild-type mice, there was a substantial anti-allodynic response. This discovery was well received by the scientific community and was considered to conclusively establish the mechanism of action of pregabalin, which has remarkably similar properties to gabapentin but with increased potency and oral absorption. This exciting result acted as an impetus for further studies on the role of the subunit in the development and maintenance of neuropathic pain.


Biomolecules ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 161 ◽  
Author(s):  
Sharma ◽  
Martins ◽  
Kuca ◽  
Chaudhary ◽  
Kabra ◽  
...  

Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.


2014 ◽  
Vol 459 (2) ◽  
pp. 417-425 ◽  
Author(s):  
Michelle L. McClure ◽  
Hui Wen ◽  
James Fortenberry ◽  
Jeong S. Hong ◽  
Eric J. Sorscher

This study provides new evidence that palmitoylation contributes to CFTR trafficking and participates during rescue of a common disease-associated mutation. Therapeutic strategies to overcome clinically important defects in cystic fibrosis should consider the role of palmitoylation as a molecular target.


2013 ◽  
Vol 154 (1-2) ◽  
pp. 61-69 ◽  
Author(s):  
Ana Ruth Araújo ◽  
Vanessa Peruhype-Magalhães ◽  
Jordana Grazziela Alves Coelho-dos-Reis ◽  
Laura Patrícia Viana Chaves ◽  
Tatiane Amábili de Lima ◽  
...  

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