5-Fluoro-2′-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy

1993 ◽  
pp. 1-8 ◽  
Author(s):  
Shousong Cao ◽  
Zhanggeng Zhang ◽  
Patrick J. Creaven ◽  
Youcef M. Rustum
Keyword(s):  
Therapeutic Efficacy

scholarly journals Chyawanprash: A Traditional Indian Bioactive Health Supplement

Biomolecules ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 161 ◽  
Author(s):  
Sharma ◽  
Martins ◽  
Kuca ◽  
Chaudhary ◽  
Kabra ◽  
...  
Keyword(s):  
Vitamin C ◽  
Therapeutic Efficacy ◽  
Therapeutic Potential ◽  
Medicinal Herbs ◽  
Indian Gooseberry ◽  
Scientific Exploration ◽  
Life Force ◽  
Dried Extract

Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.

Dual role of IL-12 in the therapeutic efficacy or failure during combined PEG-Interferon-α2A and ribavirin therapy in patients with chronic hepatitis C

2013 ◽  
Vol 154 (1-2) ◽  
pp. 61-69 ◽  
Author(s):  
Ana Ruth Araújo ◽  
Vanessa Peruhype-Magalhães ◽  
Jordana Grazziela Alves Coelho-dos-Reis ◽  
Laura Patrícia Viana Chaves ◽  
Tatiane Amábili de Lima ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Therapeutic Efficacy ◽  
Dual Role ◽  
Interferon Α2a

Technique, Complications, and Therapeutic Efficacy of Percutaneous Transplantation of Human Pancreatic Islet Cells in Type 1 Diabetes: The Role of US

Radiology ◽  
2005 ◽  
Vol 234 (2) ◽  
pp. 617-624 ◽  
Author(s):  
Massimo Venturini ◽  
Enzo Angeli ◽  
Paola Maffi ◽  
Paolo Fiorina ◽  
Federico Bertuzzi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pancreatic Islet ◽  
Therapeutic Efficacy ◽  
Islet Cells ◽  
Pancreatic Islet Cells ◽  
Human Pancreatic Islet

scholarly journals The value of naturally preformed factors of Nalchik in the rehabilitation of women with hypertension

2016 ◽  
Vol 7 (3-4) ◽  
pp. 82-85
Author(s):  
E. L Apsheva ◽  
A. A Elgarov ◽  
M. A Kalmykova ◽  
M. A Elgarov
Keyword(s):  
Therapeutic Efficacy ◽  
Restorative Treatment ◽  
Spa Treatment

The comparable therapeutic efficacy of balneotherapy with bromyoid and nitrogen-thermal baths in women with hypertension in the resort of Nalchik and the role of a spa treatment in the system of restorative treatment and rehabilitation are confirmed.

scholarly journals Daclizumab: Mechanisms of Action, Therapeutic Efficacy, Adverse Events and Its Uncovering the Potential Role of Innate Immune System Recruitment as a Treatment Strategy for Relapsing Multiple Sclerosis

Biomedicines ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 18 ◽  
Author(s):  
Stanley Cohan ◽  
Elisabeth Lucassen ◽  
Meghan Romba ◽  
Stefanie Linch
Keyword(s):  
T Cell ◽  
Adverse Events ◽  
T Cell Activation ◽  
Therapeutic Efficacy ◽  
Cell Expansion ◽  
Interleukin 2 ◽  
Phase Iii ◽  
Critical Element ◽  
Increased Risk

Daclizumab (DAC) is a humanized, monoclonal antibody that blocks CD25, a critical element of the high-affinity interleukin-2 receptor (IL-2R). DAC HYP blockade of CD25 inhibits effector T cell activation, regulatory T cell expansion and survival, and activation-induced T-cell apoptosis. Because CD25 blockade reduces IL-2 consumption by effector T cells, it increases IL-2 bioavailability allowing for greater interaction with the intermediate-affinity IL-2R, and therefore drives the expansion of CD56bright natural killer (NK) cells. Furthermore, there appears to be a direct correlation between CD56bright NK cell expansion and DAC HYP efficacy in reducing relapses and MRI evidence of disease activity in patients with RMS in phase II and phase III double-blind, placebo- and active comparator-controlled trials. Therapeutic efficacy was maintained during open-label extension studies. However, treatment was associated with an increased risk of rare adverse events, including cutaneous inflammation, autoimmune hepatitis, central nervous system Drug Reaction with Eosinophilia Systemic Symptoms (DRESS) syndrome, and autoimmune Glial Fibrillary Acidic Protein (GFAP) alpha immunoglobulin-associated encephalitis. As a result, DAC HYP was removed from clinical use in 2018. The lingering importance of DAC is that its use led to a deeper understanding of the underappreciated role of innate immunity in the potential treatment of autoimmune disease.

Hemin-lipid Assembly as Artemisinin Oral Delivery System for Enhanced Cancer Chemotherapy and Immunotherapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Qing Wang ◽  
Naijie Wei ◽  
Jingru Guo ◽  
Kai Feng ◽  
Jingwei Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Oral Delivery ◽  
Oral Delivery System

Although artemisinin (ART) has shown initial promise in cancer therapy, its therapeutic efficacy is limited by its low tumor inhibitory efficacy and unfavorable distribution. Considering the important role of heme...

Abstract 4627: Role of intratumoral cell heterogeneity on therapeutic efficacy in glioblastoma.

2013 ◽  
Author(s):  
Debyani Chakravarty ◽  
Alicia Pedraza ◽  
Angela H. Liu ◽  
Jesse Cotari ◽  
Grégoire Altan-Bonnet ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Cell Heterogeneity
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