Acute demyelinating encephalitis due toAbrus precatoriuspoisoning – complete recovery after steroid therapy

ABSTRACT:Five patients with evidence of focal encephalopathy are reported. In each case, evidence of mycoplasma pneumoniae infection was detected. No patient improved with conventional antibiotic therapy, but in three subjects, rapid and complete recovery did occur contemporaneously with the administration of high dose steroid therapy. It is suggested that focal as well as diffuse cerebral or cerebellar lesions may occur as manifestations of auto-immune disease complicating mycoplasmal infections in young people and that this illness may be designated as acute mycoplasma-associated encephalopathy.

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Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis

Case Reports in Nephrology ◽

10.1155/2019/3736495 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Varun Mamidi ◽

Manikantan Shekar ◽

Jaiju James Chakola ◽

Vamsi Krishna Makkena ◽

Jayakumar Matcha

Keyword(s):

Acute Kidney Injury ◽

Steroid Therapy ◽

Kidney Injury ◽

Complete Recovery ◽

The Body ◽

Whole Body ◽

Oral Steroid ◽

Granulomatous Disease ◽

Positron Emission ◽

Fdg Pet Ct

Background. Sarcoidosis is a chronic disease characterized by noncaseating lesions involving any organ and tissue in the body. Hypercalcemia and acute kidney injury is a common renal presentation of sarcoidosis. Necrotizing sarcoid granulomatosis (NSG) is a granulomatous disease entity which presents with nodular masses of sarcoid like granuloma which primarily effects the lungs. It is a rare necrotizing variant of sarcoidosis. Extra pulmonary presentation of NSG is very rare. Case presentation. We present a 36-year-old female with hypercalcemia and acute kidney injury refractory to treatment. Whole body Flourine-18-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET/CT) showed increased metabolic uptake with ill-defined lesions in the liver, spleen, and pelvic lymph nodes. Biopsy of the ill-defined lesions in the liver showed necrotizing granulomatous lesions without angiitis. All the markers of tuberculosis were negative and angiotensin converting enzyme levels were elevated. Patient improved with 1 mg/kg/day oral steroid therapy and is on regular follow-up with minimal dose of steroids. Conclusion. Necrotizing sarcoid granulomatosis (NSG) is a rare systemic granulomatous disease. Due to its rarity and diagnostic difficulty, treatment is challenging for clinicians, pathologists and radiologists. Treatment of choice for symptomatic patients is steroid therapy. Prognosis is good with complete recovery.

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TREATMENT OF MEASLES ENCEPHALITIS WITH ADRENAL STEROIDS

PEDIATRICS ◽

10.1542/peds.20.1.87 ◽

1957 ◽

Vol 20 (1) ◽

pp. 87-91

Author(s):

John E. Allen

Keyword(s):

Antibiotic Therapy ◽

Clinical Improvement ◽

Steroid Therapy ◽

Prophylactic Antibiotic ◽

Complete Recovery ◽

Adrenal Steroids ◽

Early Publication ◽

Prophylactic Antibiotic Therapy ◽

Untoward Reaction

Ten cases of measles encephalitis treated with large doses of adrenal steroids are presented. Apparent complete recovery occurred in all 10 cases. In most of the cases clinical improvement was dramatic and prompt. There was no evidence of untoward reaction from the use of steroids combined with prophylactic antibiotic therapy. The results in this series are further substantiated by the report of Appelbaum and Abler who reported the recovery of 16 out of 17 patients with adrenocorticotropin. It is to be emphasized that measles encephalitis is an extremely variable disease and that only prolonged experience with one form of therapy by different investigators and clinicians can determine the final efficacy of the treatment. Ten cases are not a great number from which to draw a definite conclusion in this disease, however, the results were so convincing to us that we felt an early publication of this information worthwhile in the hope that further trials will be undertaken by other groups. From our experience we recommend the treatment of measles encephalitis with steroid therapy as outlined.

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Spinal Cord Schistosomiasis: Two Different Outcomes

Case Reports in Neurology ◽

10.1159/000443787 ◽

2016 ◽

Vol 8 (1) ◽

pp. 47-52

Author(s):

Mohammed Alsomaili ◽

Ahmad A. Abulaban

Keyword(s):

Spinal Cord ◽

Plasma Exchange ◽

Steroid Therapy ◽

Early Treatment ◽

Complete Recovery ◽

Clinical Profile ◽

Pulse Steroid Therapy ◽

Initial Symptoms ◽

Pulse Steroid

Spinal cord schistosomiasis is difficult to diagnose in nonendemic areas. We report the clinical profile of 2 young Saudi males who presented with myelopathy. The first patient arrived at our hospital relatively late, i.e. 3 months following the presentation of initial symptoms, and had received both pulse steroid therapy and a plasma exchange. Praziquantel was administered late and the patient did not recover. The second case presented early, i.e. within around 8 weeks of initial symptoms. This patient received praziquantel without any kind of steroid and had a complete recovery. We concluded that prompt recognition and early treatment with praziquantel is crucial for a better outcome. The role of steroids in these cases still needs to be proven.

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Preliminary Report of a Comparative Study of Seminiferous Tubular Epithelium from Rats Flown on Cosmos 1887 and SL3

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100103449 ◽

1988 ◽

Vol 46 ◽

pp. 276-277

Author(s):

Walter J. Sapp ◽

D.E. Philpott ◽

C.S. Williams ◽

K. Kato ◽

J. Stevenson ◽

...

Keyword(s):

Space Flight ◽

Physiological Response ◽

Preliminary Report ◽

Complete Recovery ◽

Environmental Constraints ◽

Tubular Epithelium ◽

Testicular Weight ◽

Testicular Morphology ◽

Normal Offspring ◽

Rats And Mice

Space flight, with its unique environmental constraints such as immobilization, decreased and increased pressures, and radiation, is known to affect testicular morphology and spermatogenesis. Selye, summarized the manifestations of physiological response to nonspecific stress and he pointed out that atrophy of the gonads always occurred. Reports of data collected from two dogs flown in space for 22 days (Cosmos 110) indicate that there was an increase of 30 to 70% atypical spermatozoa when compared to ground based controls. Seventy-five days after the flight the abnormalities had decreased to the high normal value of 30% and mating of these dogs after this period produced normal offspring, suggesting complete recovery. Effects of immobilization and increased gravity were investigated by spinning rats and mice at 2x g for 8-9 weeks. A decrease in testicular weight was noted in spun animals when compared to controls. Immobilization has been show to cause arrest of spermatogenesis in Macaca meminstrins.

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3-D optical transfer in excitation field synthesis microscopes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100136696 ◽

1995 ◽

Vol 53 ◽

pp. 64-65

Author(s):

Vijay Krishnamurthi ◽

Brent Bailey ◽

Frederick Lanni

Keyword(s):

Standing Wave ◽

Spatial Information ◽

3D Structure ◽

Complete Recovery ◽

Weighting Factor ◽

Optical Transfer Function ◽

Excitation Field ◽

Optical Transfer ◽

Set Up ◽

Focus Plane

Excitation field synthesis (EFS) refers to the use of an interference optical system in a direct-imaging microscope to improve 3D resolution by axially-selective excitation of fluorescence within a specimen. The excitation field can be thought of as a weighting factor for the point-spread function (PSF) of the microscope, so that the optical transfer function (OTF) gets expanded by convolution with the Fourier transform of the field intensity. The simplest EFS system is the standing-wave fluorescence microscope, in which an axially-periodic excitation field is set up through the specimen by interference of a pair of collimated, coherent, s-polarized beams that enter the specimen from opposite sides at matching angles. In this case, spatial information about the object is recovered in the central OTF passband, plus two symmetric, axially-shifted sidebands. Gaps between these bands represent "lost" information about the 3D structure of the object. Because the sideband shift is equal to the spatial frequency of the standing-wave (SW) field, more complete recovery of information is possible by superposition of fields having different periods. When all of the fields have an antinode at a common plane (set to be coincident with the in-focus plane), the "synthesized" field is peaked in a narrow infocus zone.

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Obstacles to Claiming Permanence and Injury-Relatedness for “Posttraumatic” Headache

Guides Newsletter ◽

10.1001/amaguidesnewsletters.2009.mayjun02 ◽

2009 ◽

Vol 14 (3) ◽

pp. 3-6

Author(s):

Robert J. Barth

Keyword(s):

Complete Recovery ◽

World Health ◽

Related Factors ◽

Posttraumatic Headache ◽

Sixth Edition ◽

Causative Relationship ◽

Short Period ◽

The One ◽

Health Organization ◽

Subjective Reports

Abstract “Posttraumatic” headaches claims are controversial because they are subjective reports often provided in the complex of litigation, and the underlying pathogenesis is not defined. This article reviews principles and scientific considerations in the AMAGuides to the Evaluation of Permanent Impairment (AMA Guides) that should be noted by evaluators who examine such cases. Some examples in the AMA Guides, Sixth Edition, may seem to imply that mild head trauma can cause permanent impairment due to headache. The author examines scientific findings that present obstacles to claiming that concussion or mild traumatic brain injury is a cause of permanent headache. The World Health Organization, for example, found a favorable prognosis for posttraumatic headache, and complete recovery over a short period of time was the norm. Other studies have highlighted the lack of a dose-response correlation between trauma and prolonged headache complaints, both in terms of the frequency and the severity of trauma. On the one hand, scientific studies have failed to support the hypothesis of a causative relationship between trauma and permanent or prolonged headaches; on the other hand, non–trauma-related factors are strongly associated with complaints of prolonged headache.

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