The relationship between cognitive impairment and superoxide dismutase activity in untreated first-episode patients with schizophrenia

2021 ◽  
pp. 1-8
Author(s):  
Dong Mei Wang ◽  
Yu Xuan Du ◽  
Rong Rong Zhu ◽  
Yang Tian ◽  
Jia Jing Chen ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cognitive Impairment ◽  
Superoxide Dismutase Activity ◽  
First Episode ◽  
The Relationship

The relationship between ozone insensitivity, lipid-soluble antioxidants, and superoxide dismutase in Phaseolus vulgaris

1982 ◽  
Vol 60 (12) ◽  
pp. 2686-2691 ◽  
Author(s):  
B. D. McKersie ◽  
W. D. Beversdorf ◽  
P. Hucl
Keyword(s):  
Superoxide Dismutase ◽  
Phaseolus Vulgaris ◽  
Physiological Mechanism ◽  
Superoxide Dismutase Activity ◽  
Phaseolus Vulgaris L ◽  
Visual Rating ◽  
Ozone Injury ◽  
Ozone Tolerance ◽  
The Relationship ◽  
Lipid Soluble Antioxidant

Ozone insensitivity was assessed by three methods (visual rating, leakage of amino acids, and leakage of total electrolytes from leaf discs), and related to the levels of lipid-soluble antioxidants and superoxide dismutase activity in the primary leaves of different ages and of different cultivars of Phaseolus vulgaris L. The most sensitive indicator of ozone injury was visual rating. The increased variability associated with measurements of amino acid or total electrolyte leakage masked differences among cultivars which could be detected by visual rating. The correlations among the three measures of injury were high. Ozone tolerance of the primary leaf decreased between 8 and 18 days after planting and varied significantly among the 10 cultivars tested. Similarly, significant differences in lipid-soluble antioxidant content and superoxide dismutase activity were measured, but a correlation with ozone insensitivity was not established. Exposure to 20 pphm ozone for 24 h induced higher quantities of lipid-soluble antioxidant in the susceptible cv. Seafarer but not in the tolerant cv. Goldcrop. Superoxide dismutase increased similarly in both cultivars. The physiological mechanism of ozone insensitivity in the primary leaves of these cultivars of P. vulgaris was not shown to involve increased levels of lipid-soluble antioxidants or superoxide dismutase.

scholarly journals Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia

2020 ◽  
Vol 46 (6) ◽  
pp. 1498-1510 ◽  
Author(s):  
Mei Hong Xiu ◽  
Zezhi Li ◽  
Da Chun Chen ◽  
Song Chen ◽  
Maile E Curbo ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cognitive Impairment ◽  
Clinical Symptoms ◽  
Interactive Effect ◽  
Redox System ◽  
First Episode ◽  
Sod Activity ◽  
Neuropsychological Status ◽  
Syndrome Scale ◽  
Drug Naïve

Abstract The pathogenesis and etiology of schizophrenia (SCZ) remains unclear. Accumulating studies showed that complex interrelationships between brain-derived neurotrophic factor (BDNF) and an imbalanced redox system has a crucial role in the psychopathology of SCZ. However, the influence of the interrelationships of BDNF and superoxide dismutase (SOD) on cognitive impairment and clinical symptomatology in drug-naive first-episode (DNFE) SCZ patients has not been studied thoroughly. Serum BDNF levels, plasma total SOD, manganese-SOD (Mn-SOD), copper/zinc-containing SOD (CuZn-SOD) activities, and malondialdehyde (MDA) levels were measured in 327 DNFE patients with SCZ and 391 healthy controls. Cognitive functions were measured using the Repeatable Battery for the Assessment of Neuropsychological status (RBANS) and clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS). Compared with the controls, the DNFE patients had increased activities of total SOD and CuZn-SOD, and reduced levels of BDNF and MDA. BDNF levels were positively correlated with CuZn-SOD activity in patients. In addition, we found that elevated Mn-SOD and CuZn-SOD activities were related to PANSS depression factor. Moreover, an interactive effect of BDNF levels and Mn-SOD activity was associated with attentional index score in the patients. Therefore, our findings suggested that interrelationships between BDNF and antioxidant mechanisms might underlie the pathological mechanisms of cognitive impairments and symptomatology in the DNFE patients with SCZ.

Late-Life Depressive Disorder in the Community

1995 ◽  
Vol 166 (3) ◽  
pp. 311-315 ◽  
Author(s):  
Rob Van Ojen ◽  
Chris Hooijer ◽  
Dick Bezemer ◽  
Cees Jonker ◽  
Jaap Lindeboom ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Late Onset ◽  
First Episode ◽  
Psychiatric History ◽  
Elderly Individuals ◽  
Stratified Sample ◽  
History Of ◽  
The Relationship ◽  
State Examination ◽  
Young Old

BackgroundIn previous studies cognitive impairment in depressed elderly in-patients tends to be associated with a late onset of depression. This study tests the hypothesis that cognitive impairment is associated with depression only in elderly individuals with no history of psychiatric illness.MethodWe investigated an age-stratified sample of 4051 elderly people living in the community, aged between 65 and 84 (AMSTEL). The relationship between depression (GMS-AGECAT diagnosis) and scores on the Mini Mental State Examination was studied in subjects with and without a reported psychiatric history (CAMDEX questionnaire).ResultsLow MMSE scores (MMSE ≤ 25) were only associated with depression in subjects with no psychiatric history (young/old: OR = 2.75, 95% CI = 1.83, 4.19; old/old: OR = 2.21, 95% CI = 1.61, 3.03).ConclusionsWe concluded that the combination of cognitive impairment and first-episode depression in elderly individuals may indicate cerebral deterioration. Depression as such may not be associated with cognitive impairment.

scholarly journals Sleep Disturbance Severity is Associated With Cognitive Impairment in Patients With First-episode, Treatment-naïve Major Depressive Disorders

2020 ◽  
Author(s):  
Feihuan Cui ◽  
Qi Liu ◽  
Xiaozhen Lv ◽  
Rainer Leonhart ◽  
Hongjun Tian ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Information Processing ◽  
Sleep Disturbance ◽  
Sleep Disorders ◽  
Processing Speed ◽  
First Episode ◽  
Information Processing Speed ◽  
Major Depressive ◽  
Treatment Naïve ◽  
The Relationship

Abstract BackgroundSleep disorders and cognitive impairment are common in patients with major depressive disorder (MDD), though the relationship between the two remains unclear. We investigated this association in first-episode, treatment-naïve patients with MDD.MethodWe analyzed data from 242 patients withMDD. We divided the patients into 2 groups based on sleep disturbance severity and compared the cognitive impairment odds ratios in different domains between the groups.ResultsA total of 121 pairs of patients were matched (age39.4±10.1, 70.2% female). After propensity score matching, the odds ratios for cognitive impairment in patients with MDD and serious sleep disorders were 1.922 (1.068–3.459, P= 0.029) in executive functioning; 2.023 (1.211–3.379, P= 0.007) in executive shifting; 1.749 (1.000–3.060, P = 0.050) in executive inhibition; and 1.813 (1.038–3.167, P = 0.037) in information processing speed.LimitationsThe cross-sectional data on the relationship between sleep disorders and cognitive impairment were weak. Our study population was restricted to Chinese adults aged 18 to 65 years, so the results may not be generalizable to other populations.Because our sample size was limited, some variables were not included in the study.ConclusionsSleep disturbance is associated with cognitive impairment in the domains of executive functioning and information processing speed in first-episode, treatment-naïve patients with MDD. Sleep problems can be important symptoms for physicians in clinical practice and can aid in recognizing cognitive impairment in patients with MDD. Further study is required to confirm our results.Trial registrationClinicalTrials.gov: NCT02023567; registration date: December 2013.

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