One-pot three-component reaction of arylglyoxals with acetylthiourea and Meldrum’s acid or barbituric acid for synthesis of new 2-acetamido-4-arylthiazol-5-yl derivatives
An efficient and simple method for the synthesis of 1-aryl-1,2-dihydro-benzo[f]chromen-3-ones via a one-pot three-component reaction of β-naphthol, arylaldehydes and Meldrum's acid with Et3N as a base in CH3CN under reflux is reported. All the products were obtained in good to excellent yields and their structures were established from their spectroscopic data.
A one-pot method for the preparation of new 4-aryl-2-thioxo-3,4-dihydropyrimidines via a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea in the presence of p-toluenesulfonic acid as catalyst in CH3CN under reflux is reported.
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An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline-
2,5,10(1H)-triones was developed for the first time. The process proceeded via the
three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid
and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)-
one-ring naphthoquinones have been synthesized with good to high yields in refluxing
ethanol as a green reaction medium. This protocol is simple and effective as well as does
not involve the assistance of the catalyst, additive, or hazardous solvents.
Synthesis of 4-aryl-2-Thioxo-3,4-Dihydropyrimidines Using a Three-Component Reaction of Meldrum's Acid with Arylaldehydes and Acetylthiourea