An efficient synthesis of polyfunctionalized pyrroles by three-component reaction of arylglyoxals, Meldrum’s acid and ethyl 2-chloro-3-(arylamino)but-2-enoates

2022 ◽  
Author(s):  
Fereshteh Nezhad-shahrokhabadi ◽  
Mohammad Anary-Abbasinejad
Keyword(s):  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Three Component Reaction

Synthesis of functionalized chromones through sequential reactions in aqueous media

2014 ◽  
Vol 12 (30) ◽  
pp. 5757-5765 ◽  
Author(s):  
Saber Mehrparvar ◽  
Saeed Balalaie ◽  
Mahnaz Rabbanizadeh ◽  
Frank Rominger ◽  
Elmira Ghabraie
Keyword(s):  
Aqueous Media ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Primary Alcohols ◽  
Meldrum’S Acid ◽  
Synthesis Protocol ◽  
Sequential Reactions

An efficient synthesis protocol has been developed for diversity-oriented functionalized compounds via four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols in aqueous media.

One-Pot Three-Component Condensation of β-Naphthol with Arylaldehydes and Meldrum's Acid: Synthesis of 1-Aryl-1,2-Dihydro-Benzo[f]Chromen-3-Ones

2017 ◽  
Vol 41 (4) ◽  
pp. 250-252 ◽  
Author(s):  
Hossein Mehrabi ◽  
Faezeh Najafian-Ashrafi ◽  
Reza Ranjbar-Karimi
Keyword(s):  
Spectroscopic Data ◽  
Acid Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
Simple Method ◽  
Three Component Reaction

An efficient and simple method for the synthesis of 1-aryl-1,2-dihydro-benzo[f]chromen-3-ones via a one-pot three-component reaction of β-naphthol, arylaldehydes and Meldrum's acid with Et3N as a base in CH3CN under reflux is reported. All the products were obtained in good to excellent yields and their structures were established from their spectroscopic data.

Synthesis of Disubstituted γ-Butyrolactones and Spirocyclopropanes via Multicomponent Reaction of Aldehydes, Meldrum’s Acid and Sulfoxonium Ylides

2021 ◽  
Author(s):  
Shan-Shan Li ◽  
Qi Qin ◽  
Zhuang Qi ◽  
Li-Miao Yang ◽  
Yun Kang ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Aromatic Aldehydes ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Mild Conditions

An efficient synthesis of disubstituted γ-butyrolactones and spirocyclopropanes via multicomponent reaction of aldehydes, Meldrum’s acid and sulfoxonium ylides has been developed. Under mild conditions, electron-rich aromatic aldehydes reacted with Meldrum’s...

scholarly journals One Pot, Four Component Synthesis of Phthalazine-1,4-diones Derivatives in [BMIM][OH] Medium

2019 ◽  
Vol 32 (1) ◽  
pp. 45-48
Author(s):  
D.P. Loka Maheshwari ◽  
B. Satyanarayana
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Diethyl Phthalate ◽  
High Yield ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot

[BMIM][OH] mediated, green and efficient synthesis of phthalazines (5) have been developed by condensing diethyl phthalate (1), ethyl cyanohydrazide (2), substituted benzaldehyde (3) and malononitrile (4) in the presence of Meldrum’s acid at 60-65 °C and at room temperature for 60-90 min. The importance of this method includes shorter reaction time and high yield.

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