One-Pot Three-Component Reaction between 2-Aminopyridines, Aldehydes and Meldrum’s Acid in Water: An Efficient Synthesis of β-Amino Acids

Synlett ◽  
2008 ◽  
Vol 2008 (20) ◽  
pp. 3177-3179 ◽  
Author(s):  
Mehdi Adib ◽  
Solmaz Fatemi ◽  
Meisam Nosrati ◽  
Hamid Bijanzadeh
Keyword(s):  
Amino Acids ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
Three Component Reaction

One-Pot Three-Component Condensation of β-Naphthol with Arylaldehydes and Meldrum's Acid: Synthesis of 1-Aryl-1,2-Dihydro-Benzo[f]Chromen-3-Ones

2017 ◽  
Vol 41 (4) ◽  
pp. 250-252 ◽  
Author(s):  
Hossein Mehrabi ◽  
Faezeh Najafian-Ashrafi ◽  
Reza Ranjbar-Karimi
Keyword(s):  
Spectroscopic Data ◽  
Acid Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
Simple Method ◽  
Three Component Reaction

An efficient and simple method for the synthesis of 1-aryl-1,2-dihydro-benzo[f]chromen-3-ones via a one-pot three-component reaction of β-naphthol, arylaldehydes and Meldrum's acid with Et3N as a base in CH3CN under reflux is reported. All the products were obtained in good to excellent yields and their structures were established from their spectroscopic data.

scholarly journals One Pot, Four Component Synthesis of Phthalazine-1,4-diones Derivatives in [BMIM][OH] Medium

2019 ◽  
Vol 32 (1) ◽  
pp. 45-48
Author(s):  
D.P. Loka Maheshwari ◽  
B. Satyanarayana
Keyword(s):  
Reaction Time ◽  
Room Temperature ◽  
Diethyl Phthalate ◽  
High Yield ◽  
Efficient Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot

[BMIM][OH] mediated, green and efficient synthesis of phthalazines (5) have been developed by condensing diethyl phthalate (1), ethyl cyanohydrazide (2), substituted benzaldehyde (3) and malononitrile (4) in the presence of Meldrum’s acid at 60-65 °C and at room temperature for 60-90 min. The importance of this method includes shorter reaction time and high yield.

scholarly journals Synthesis of 4-aryl-2-Thioxo-3,4-Dihydropyrimidines Using a Three-Component Reaction of Meldrum's Acid with Arylaldehydes and Acetylthiourea

2018 ◽  
Vol 42 (6) ◽  
pp. 326-328 ◽  
Author(s):  
Hossein Mehrabi ◽  
Tayebeh Yarahmadi ◽  
Farzaneh Alizadeh Bami
Keyword(s):  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
Toluenesulfonic Acid ◽  
Three Component Reaction

A one-pot method for the preparation of new 4-aryl-2-thioxo-3,4-dihydropyrimidines via a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea in the presence of p-toluenesulfonic acid as catalyst in CH3CN under reflux is reported.

An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g] quinoline-2,5,10(1H)-triones under Green Conditions

2020 ◽  
Vol 23 (23) ◽  
pp. 2626-2634
Author(s):  
Saiedeh Kamalifar ◽  
Hamzeh Kiyani
Keyword(s):  
Reaction Medium ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
First Time ◽  
Green Conditions

: An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline- 2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)- one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

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