Hemophilic arthropathy: a teaching approach devoted to hemophilia treaters in under-development countries

Author(s):  
E. Carlos Rodriguez-Merchan
Blood ◽  
2006 ◽  
Vol 108 (9) ◽  
pp. 3053-3060 ◽  
Author(s):  
Maureane Hoffman ◽  
Anna Harger ◽  
Angela Lenkowski ◽  
Ulla Hedner ◽  
Harold R. Roberts ◽  
...  

Abstract We used a mouse model to test the hypothesis that the time course and histology of wound healing is altered in hemophilia B. Punch biopsies (3 mm) were placed in the skin of normal mice and mice with hemophilia. The size of the wounds was measured daily until the epidermal defect closed. All wounds closed in mice with hemophilia by 12 days, compared with 10 days in normal animals. Skin from the area of the wound was harvested at different time points and examined histologically. Hemophilic animals developed subcutaneous hematomas; normal animals did not. Macrophage infiltration was significantly delayed in hemophilia B. Unexpectedly, hemophilic mice developed twice as many blood vessels in the healing wounds as controls, and the increased vascularity persisted for at least 2 weeks. The deposition and persistence of ferric iron was also greater in hemophilic mice. We hypothesize that iron plays a role in promoting excess angiogenesis after wounding as it had been proposed to do in hemophilic arthropathy. We have demonstrated that impaired coagulation leads to delayed wound healing with abnormal histology. Our findings have significant implications for treatment of patients with hemophilia, and also highlight the importance of rapidly establishing hemostasis following trauma or surgery.


2015 ◽  
Vol 19 (2) ◽  
pp. 123-132
Author(s):  
Luciana Fornari Colombo

Ludwig Mies van der Rohe's idea of a modern courtyard house is explored in this article considering three aspects: context stimuli, development, and practical applications. In this manner, this article provides significant contributions to the understanding of Mies's courtyard house idea. In fact, so far the stimuli and motivations behind his studies on this house type have been insufficiently explored. This obscurity has facilitated hypotheses such as that some of the courtyard house projects that Mies attributed to himself were not designed by him, but by his students and assistants. This article offers an alternative view of this issue that supports the architect's original claims by clarifying his teaching approach, creative process, and historical context. This article also clarifies the development of Mies's courtyard house idea through several projects that he designed on this theme, including the Courtyard House with Round Skylight (1934), which has been little explored in previous literature. Ultimately, this article examines the practical applications of Mies's courtyard house idea, both as a motif of student exercise and as an architectural solution for low dwellings, showing that this idea has maintained its relevance throughout the decades.


2020 ◽  
Vol 5 (3) ◽  
pp. 32-38
Author(s):  
Fakhriddin Nuraliev ◽  
◽  
Ulugbek Giyosov

Since the last few decades, virtual reality (VR) and augmented reality (AR) interfaces have shown the potential to enhance teaching and learning, by combining physical and virtual worlds and leveraging the advantages of both. Conservative techniques of content presentation (fixed video, audio, scripts) lack personalization and interaction.


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