Research progress in the role of gut microbiota and its metabolites in intrahepatic cholestasis of pregnancy

2021 ◽  
Author(s):  
Shuaijun Ren ◽  
Yuping Zhou ◽  
Rongrong Xuan
Keyword(s):  
Gut Microbiota ◽  
Intrahepatic Cholestasis ◽  
Research Progress ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

scholarly journals Characterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Rong Li ◽  
Xuehai Chen ◽  
Zhongzhen Liu ◽  
Yan Chen ◽  
Chuan Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Pregnant Women ◽  
Intrahepatic Cholestasis ◽  
Premature Delivery ◽  
Clinical Parameters ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Control Groups ◽  
And Control ◽  
Cholestasis Of Pregnancy

Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that specifically occurs in pregnancy. Elevated levels of liver transaminases aspartate aminotransferase, alanine aminotransferase and serum bilirubin levels are common biochemical characteristics in ICP. The disorder is associated with an increased risk of premature delivery and stillbirth. The characterization of the potential microbiota in ICP could go a long way in the prevention and treatment of this pregnancy disease. Methods A total of 58 patients were recruited for our study: 27 ICP patients and 31 healthy pregnant subjects with no ICP. The V3 and V4 regions of the 16S rDNA collected from fecal samples of both diseased and control groups were amplified. 16S rRNA gene amplicon sequencing was then performed on gut microbiota. Sequencing data were analyzed and the correlation between components of microbiota and patient ICP status was found. Related metabolic pathways, relative abundance and significantly different operational taxonomic units (OTUs) between ICP and controls were also identified. Results Elevated levels of total bile acid, ALT, AST, Dbil and Tbil were recorded or observed in ICP subjects as compared to the control. Gut microbiota in pregnant women was dominated by four major phyla and 27 core genera. PCoA analysis results indicated that there was no significant clustering in Bray–Curtis distance matrices. Our results showed that there was a correlation between specific OTUs and measured clinical parameters of pregnant women. Comparison at the different taxonomy levels revealed high levels of abundance of Blautia and Citrobacter in ICP patients. At the family level, Enterobacteriaceae and Leuconostocaceae were higher in ICP patients. 638 KEGG Orthologs and 138 pathways significantly differed in the two groups. PLS-DA model with VIP plots indicated a total of eight genera and seven species were key taxa in ICP and control groups. Conclusions Our research indicated that although there was no significant clustering by PCoA analysis, patients with ICP have increased rare bacteria at different phylogenetic levels. Our results also illustrated that all 638 KEGG Orthologs and 136 in 138 KEGG pathways were less abundant in ICP patients compared to the controls.

Exploring the genetic role of the HLA-DPB1 locus in Chileans with intrahepatic cholestasis of pregnancy

1996 ◽  
Vol 24 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Juan G. Mella ◽  
Elke Roschmann ◽  
Juan C. Glasinovic ◽  
Alejandra Alvarado ◽  
Mirella Scrivanti ◽  
...  
Keyword(s):  
Intrahepatic Cholestasis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

scholarly journals The Role of Steroid Hormones in the Development of Intrahepatic Cholestasis of Pregnancy

2015 ◽  
pp. S203-S209 ◽  
Author(s):  
A. PAŘÍZEK ◽  
M. DUŠKOVÁ ◽  
L. VÍTEK ◽  
M. ŠRÁMKOVÁ ◽  
M. HILL ◽  
...  
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Steroid Hormones ◽  
Intrahepatic Cholestasis ◽  
Point Of View ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Hepatic Transaminases ◽  
Exogenous Factors ◽  
Cholestasis Of Pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is a disorder of liver function, commonly occurring in the third trimester but sometimes also as soon as the end of the second trimester of pregnancy. Symptoms of this disorder include pruritus, plus abnormal values of bile acids and hepatic transaminases. After birth, symptoms disappear and liver function returns to normal. Though ICP is relatively non-complicated and often symptomatically mild from the point-of-view of the mother, it presents a serious risk to the fetus, making this disease the subject of great interest. The etiology and pathogenesis of ICP is multifactorial and as yet not fully elucidated. Hormonal factors likely play a significant role, along with genetic as well as exogenous factors. Here we summarize the knowledge of changes in steroid hormones and their role in the development of intrahepatic cholestasis of pregnancy. In addition, we consider the role of exogenous factors as possible triggers of steroid hormone changes, the relationship between metabolic steroids and bile acids, as well as the combination of these factors in the development of ICP in predisposed pregnant women.

scholarly journals The role of ABC transporters’ gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy

2018 ◽  
Vol 89 (7) ◽  
pp. 393-397 ◽  
Author(s):  
Krzysztof Piątek ◽  
Grażyna Kurzawińska ◽  
Justyna Magiełda ◽  
Krzysztof Drews ◽  
Magdalena Barlik ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Abc Transporters ◽  
Intrahepatic Cholestasis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

The Role of Melatonin, IL-8 and IL-10 in Intrahepatic Cholestasis of Pregnancy

2020 ◽  
Author(s):  
Samettin Çelik ◽  
Huri Guve ◽  
Canan Çalışkan ◽  
Sebahattin Çelik
Keyword(s):  
Intrahepatic Cholestasis ◽  
Inflammatory Cytokine ◽  
Elevated Serum ◽  
Interleukin 10 ◽  
Interleukin 8 ◽  
Controlled Study ◽  
Control Group ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy

Abstract Introduction Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease that usually emerges during the third trimester of pregnancy. It is characterized by itching and elevated serum total bile acid levels, and it may lead to severe fetal complications. This study aimed to investigate the role of interleukin-8, a pro-inflammatory cytokine; interleukin-10, an anti-inflammatory cytokine; and melatonin in intrahepatic cholestasis of pregnancy. Materials and Methods This prospective, case-controlled study was conducted with 51 women with intrahepatic cholestasis of pregnancy (40 mild and 11 severe cases) and 43 healthy pregnant women. Serum interleukin-8, interleukin-10, and melatonin levels were evaluated. Results Melatonin and interleukin -10 were significantly lower in subjects with intrahepatic cholestasis of pregnancy (p=0.001; p=0.001, respectively p<0.05). Interleukin-8 levels were found to be significantly higher in the cholestasis group than control group (p=0.001, p<0.05). Conclusions Because interleukin-8, interleukin-10, and melatonin were found to be significantly correlated with intrahepatic cholestasis of pregnancy, we believe this finding could shed light on the etiology of the disease.

The role of interleukin-17 in intrahepatic cholestasis of pregnancy

2015 ◽  
Vol 29 (6) ◽  
pp. 977-981 ◽  
Author(s):  
Ayse Kirbas ◽  
Ebru Biberoglu ◽  
Ali Ozgur Ersoy ◽  
Asiye Ugras Dikmen ◽  
Cemile Koca ◽  
...  
Keyword(s):  
Intrahepatic Cholestasis ◽  
Interleukin 17 ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Cholestasis Of Pregnancy
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