scholarly journals Does the evidence support the implementation of lung cancer screening with low-dose computed tomography?

2018 ◽  
Vol 12 (4) ◽  
pp. 257-260 ◽  
Author(s):  
Paul F. Pinsky
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Cancer Screening ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Low Dose Computed Tomography

LOW-DOSE COMPUTED TOMOGRAPHY IN MOSCOW FOR LUNG CANCER SCREENING (LDCT-MLCS): BASELINE RESULTS

2019 ◽  
Vol 65 (2) ◽  
pp. 224-233
Author(s):  
Sergey Morozov ◽  
Viktor Gombolevskiy ◽  
Anton Vladzimirskiy ◽  
Albina Laypan ◽  
Pavel Kononets ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Cancer Screening ◽  
Low Dose ◽  
Early Stage ◽  
Lung Cancer Screening ◽  
Stage I ◽  
Malignant Neoplasms ◽  
Number Needed To Screen ◽  
Low Dose Computed Tomography

Study aim. To justify selective lung cancer screening via low-dose computed tomography and evaluate its effectiveness. Materials and methods. In 2017 we have concluded the baseline stage of “Lowdose computed tomography in Moscow for lung cancer screening (LDCT-MLCS)” trial. The trial included 10 outpatient clinics with 64-detector CT units (Toshiba Aquilion 64 and Toshiba CLX). Special low-dose protocols have been developed for each unit with maximum effective dose of 1 mSv (in accordance with the requirements of paragraph 2.2.1, Sanitary Regulations 2.6.1.1192-03). The study involved 5,310 patients (53% men, 47% women) aged 18-92 years (mean age 62 years). Diagnosis verification was carried out in the specialized medical organizations via consultations, additional instrumental, laboratory as well as pathohistological studies. The results were then entered into the “National Cancer Registry”. Results. 5310 patients (53% men, 47% women) aged 18 to 92 years (an average of 62 years) participated in the LDCT-MLCS. The final cohort was comprised of 4762 (89.6%) patients. We have detected 291 (6.1%) Lung-RADS 3 lesions, 228 (4.8%) Lung- RADS 4A lesions and 196 (4.1%) Lung-RADS 4B/4X lesions. All 4B and 4X lesions were routed in accordance with the project's methodology and legislative documents. Malignant neoplasms were verified in 84 cases (1.76% of the cohort). Stage I-II lung cancer was actively detected in 40.3% of these individuals. For the first time in the Russian Federation we have calculated the number needed to screen (NNS) to identify one lung cancer (NNS=57) and to detect one Stage I lung cancer (NNS=207). Conclusions. Based on the global experience and our own practices, we argue that selective LDCT is the most systematic solution to the problem of early-stage lung cancer screening.

P61.10 Swiss Pilot Low-Dose Computed Tomography Lung Cancer Screening Study

2021 ◽  
Vol 16 (10) ◽  
pp. S1176
Author(s):  
L. Jungblut ◽  
J. Walter ◽  
C. Zellweger ◽  
M. Patella ◽  
D. Franzen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Cancer Screening ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Screening Study ◽  
Low Dose Computed Tomography

scholarly journals Cost-effectiveness of lung cancer screening with low-dose computed tomography in heavy smokers: a microsimulation modelling study

2020 ◽  
Vol 135 ◽  
pp. 121-129 ◽  
Author(s):  
Yihui Du ◽  
Grigory Sidorenkov ◽  
Marjolein A. Heuvelmans ◽  
Harry J.M. Groen ◽  
Karin M. Vermeulen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Low Dose Computed Tomography ◽  
Heavy Smokers ◽  
Modelling Study

scholarly journals Organ Dose and Attributable Cancer Risk in Lung Cancer Screening with Low-Dose Computed Tomography

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155722 ◽  
Author(s):  
Natalia Saltybaeva ◽  
Katharina Martini ◽  
Thomas Frauenfelder ◽  
Hatem Alkadhi
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Cancer Screening ◽  
Cancer Risk ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Organ Dose ◽  
Low Dose Computed Tomography
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