scholarly journals Re-determination of upper reference range of follicular stimulating hormone in infertile men

2020 ◽  
Vol 66 (5) ◽  
pp. 329-336
Author(s):  
Muharrem Ozkaya ◽  
Unal Oztekin ◽  
Mehmet Caniklioglu ◽  
Oguz Ekmekcioglu
Keyword(s):  
Reference Range ◽  
Infertile Men ◽  
Follicular Stimulating Hormone ◽  
Stimulating Hormone

THE EFFECT OF CLOMIPHENE ON URINARY GONADOTROPHINS IN INFERTILE MEN

1972 ◽  
Vol 70 (4) ◽  
pp. 654-664 ◽  
Author(s):  
Peter Christiansen
Keyword(s):  
Side Effects ◽  
Luteinizing Hormone ◽  
Clomiphene Citrate ◽  
Follicle Stimulating Hormone ◽  
Urine Samples ◽  
Pronounced Increase ◽  
Infertile Men ◽  
Stimulating Hormone

ABSTRACT In order to study the effect on urinary hypophyseal gonadotrophins as measured by specific bioassays, 19 infertile men aged 26 to 47 years, average 30.8, were treated with clomiphene citrate (Clomivid®) 50 mg daily for 30 days. During the last 8 days of treatment 24 hour urine samples were collected daily for the determination of total hypophyseal gonadotrophins (HG), follicle stimulating hormone (FSH) and luteinizing hormone (LH). HG, FSH and LH rose equally to an average of 3 times the control values, the increase being highly significant statistically (P < 0.001). The most pronounced increase was observed in the cases with the lowest control values. Only one patient failed to respond. No side effects due to the drug were observed.

Level of thyroid-stimulating hormone as basic diagnostic marker and criterion of treatment success of thyroid diseases

2017 ◽  
pp. 102-106
Author(s):  
V.I. Pankiv ◽  
Keyword(s):  
Key Words ◽  
Functional State ◽  
Diagnostic Marker ◽  
Treatment Success ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Diseases ◽  
Early Diagnostics ◽  
Basic Test ◽  
Stimulating Hormone

In the article information is generalized on the aspects of early diagnostics of thyrois disorders. The value of thyroid-stimulating hormone is underlined as basic test for determination of the thyroid functional state and criterion of treatment success of thyroid diseases. Key words: thyroid, thyroid-stimulating hormone, diagnostics.

Thyroid-stimulating hormone reference range and factors affecting it in a nationwide random sample

2014 ◽  
Vol 52 (12) ◽  
Author(s):  
Ville L. Langén ◽  
Teemu J. Niiranen ◽  
Juhani Mäki ◽  
Jouko Sundvall ◽  
Antti M. Jula
Keyword(s):  
Risk Factor ◽  
Random Sample ◽  
Reference Range ◽  
Statistical Significance ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Healthy Population ◽  
Reference Ranges ◽  
And Gender ◽  
Stimulating Hormone

AbstractPrevious studies with mainly selected populations have proposed contradicting reference ranges for thyroid-stimulating hormone (TSH) and have disagreed on how screening, age and gender affect them. This study aimed to determine a TSH reference range on the Abbott Architect ci8200 integrated system in a large, nationwide, stratified random sample. To our knowledge this is the only study apart from the NHANES III that has addressed this issue in a similar nationwide setting. The effects of age, gender, thyroid peroxidase antibody (TPOAb)-positivity and medications on TSH reference range were also assessed.TSH was measured from 6247 participants randomly drawn from the population register to represent the Finnish adult population. TSH reference ranges were established of a thyroid-healthy population and its subpopulations with increasing and cumulative rigour of screening: screening for overt thyroid disease (thyroid-healthy population, n=5709); screening for TPOAb-positivity (risk factor-free subpopulation, n=4586); and screening for use of any medications (reference subpopulation, n=1849).The TSH reference ranges of the thyroid-healthy population, and the risk factor-free and reference subpopulations were 0.4–4.4, 0.4–3.7 and 0.4–3.4 mU/L (2.5th–97.5th percentiles), respectively. Although the differences in TSH between subgroups for age (p=0.002) and gender (p=0.005) reached statistical significance, the TSH distribution curves of the subgroups were practically superimposed.We propose 0.4–3.4 mU/L as a TSH reference range for adults for this platform, which is lower than those presently used in most laboratories. Our findings suggest that intensive screening for thyroid risk factors, especially for TPOAb-positivity, decreases the TSH upper reference limit.

scholarly journals Recombinant Follicular Stimulating Hormone Plus Recombinant Luteinizing Hormone Versus Human Menopausal Gonadotropins- Does the Source of LH Bioactivity Affect Ovarian Stimulation Outcome?

2021 ◽  
Author(s):  
Michal Kirshenbaum ◽  
Or Gil ◽  
Jigal Haas ◽  
Ravit Nahum ◽  
Eran Zilberberg ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Stimulation ◽  
Intracellular Signaling ◽  
Physiological Role ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Common Receptor ◽  
The Mean ◽  
Follicular Stimulating Hormone ◽  
Stimulating Hormone

Abstract Background: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) activate distinct intracellular signaling cascades. However, due to their similar structure and common receptor, they are used interchangeably during ovarian stimulation (OS). This study aims to assess if the source of LH used during OS affects IVF outcome. Materials and methods: This was a cross sectional study of patients who underwent two consecutive IVF cycles, one included recombinant follicular stimulating hormone (FSH) plus recombinant LH [rFSH+rLH, (Pergoveris)] and the other included urinary hCG [highly purified hMG (HP-hMG), (Menopur)]. The OS protocol, except of the LH preparation, was identical in the two IVF cycles. Results: The rate of mature oocytes was not different between the treatment cycles (0.9 in the rFSH+rLH vs 0.8 in the HP-hMG, p=0.07). Nonetheless, the mean number of mature oocytes retrieved in the rFSH+rLH treatment cycles was higher compared to the HP-hMG treatment cycles (10 ± 5.8 vs 8.3 ±4.6, respectively, P=0.01). Likewise, the mean number of fertilized oocytes was higher in the rFSH+rLH cycles compared with the HP-hMG cycles (8.5 ± 5.9 vs 6.4 ± 3.6, respectively, p=0.05). There was no difference between the treatment cycles regarding the number of top-quality embryos, the ratio of top-quality embryos per number of oocytes retrieved or fertilized oocytes or the pregnancy rate. Conclusion: The differences in treatment outcome, derived by different LH preparations reflect the distinct physiological role of these molecules. Our findings may assist in tailoring a specific GT regimen when assembling an OS protocol.

Prognostic value of levels of specific autoantibodies in patients of reproductive age with endometrial polyps

2021 ◽  
pp. 33-36
Author(s):  
L. V. Tkachenko ◽  
N. I. Sviridova ◽  
I. A. Gritsenko ◽  
S. N. Maksimov
Keyword(s):  
Blood Serum ◽  
Prognostic Value ◽  
Reference Range ◽  
Relative Content ◽  
Reproductive Age ◽  
Enzyme Linked Immunosorbent Assay ◽  
Women Of Reproductive Age ◽  
Endometrial Polyps ◽  
Double Stranded Dna

The problem of endometrial polyps in women of reproductive age is one of the urgent problems of modern gynecology. The detection rate of PE according to the data of domestic and foreign scientists reaches 25–35%, and therefore they occupy a leading place in the structure of intrauterine pathology.The aim. To study the levels of specific autoantibodies (to double-stranded DNA; to TrM‑03 antigens and collagen) and to assess their prognostic value for the risk of PE formation and recurrence in patients of reproductive age.Materials and methods. Examination of 86 patients aged 18 to 45 years (average age was 34.1 ± 6.3 years), admitted for hysteroscopy, hysteroresection of PE. Study of the relative content of specific autoantibodies to double-stranded DNA; to TrM‑03 antigens and collagen in blood serum was carried out by the method of enzyme-linked immunosorbent assay using specialized reagent kits (ELI-P-Complex).Results. In the course of this study, it was found that in the overwhelming majority of cases (65.1%) PEs were manifested by various types of AMC. All patients with PE were diagnosed with a significant decrease in the level of autoantibodies to double-stranded DNA, which is a marker of apoptosis processes, as well as a statistically significant decrease in the levels of autoantibodies to platelet antigens TrM‑03. The profile of deviations in the level of autoantibodies to TrM‑03 from the reference range in the area of negative values correlated with an increase in the average level of autoantibodies to collagen.Conclusions. Determination of the levels of auto-ATs to double-stranded DNA in serum can be used as a marker for predicting the recurrent course of PE. Determination of the levels of auto-ATs to platelet antigens TrM‑03 and to collagen in blood serum can be used as markers for the development of AMC by the type of BMC or a combination of BMC and BMC in patients with endometrial polyps.

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