scholarly journals Metabolomics reveals the renoprotective effect of n-butanol extract and amygdalin extract from Amygdalus mongolica in rats with renal fibrosis

2021 ◽  
Vol 49 (1) ◽  
pp. 556-564
Author(s):  
Wanfu Bai ◽  
Qing Liu ◽  
Hong Chang ◽  
Quanli Liu ◽  
Chen Gao ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Renoprotective Effect ◽  
Butanol Extract

Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis

2019 ◽  
Vol 212 ◽  
pp. 1-10 ◽  
Author(s):  
Hailun Li ◽  
Zhuan Yan ◽  
Qingping Xiong ◽  
Xiaoling Chen ◽  
Yongtao Lin ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Renoprotective Effect ◽  
Polyporus Umbellatus

scholarly journals Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach

2021 ◽  
Vol 22 (8) ◽  
pp. 3887
Author(s):  
Maja Kosanović ◽  
Alicia Llorente ◽  
Sofija Glamočlija ◽  
José M. Valdivielso ◽  
Milica Bozic
Keyword(s):  
Extracellular Vesicles ◽  
Therapeutic Approach ◽  
Renal Fibrosis ◽  
Functional Role ◽  
Therapeutic Agents ◽  
Renal Diseases ◽  
Future Perspectives ◽  
Renoprotective Effect ◽  
Complex Disorder ◽  
Biological Barriers

Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases.

Activation of autophagy contributes to the renoprotective effect of postconditioning on acute kidney injury and renal fibrosis

2018 ◽  
Vol 504 (4) ◽  
pp. 641-646 ◽  
Author(s):  
Yaolin Song ◽  
Qianyu Tao ◽  
Lixia Yu ◽  
Ling Li ◽  
Tingting Bai ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Fibrosis ◽  
Kidney Injury ◽  
Renoprotective Effect

511-P: The Renoprotective Effect of Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, in a Mouse Model of Renal Fibrosis

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 511-P
Author(s):  
NAYOUNG KIM ◽  
IN-KYU LEE ◽  
SUNG DON PARK ◽  
MIN-JI KIM ◽  
JUNG-GUK KIM ◽  
...  
Keyword(s):  
Mouse Model ◽  
Renal Fibrosis ◽  
Dipeptidyl Peptidase ◽  
Renoprotective Effect ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitor

scholarly journals Metabolomics Reveals the Renoprotective Effect of N-butanol Extract and Amygdalin Extract From Amygdalus Mongolica in Rats With Renal Fibrosis

2020 ◽  
Author(s):  
wanfu BAI ◽  
Qing Liu ◽  
Hong Chang ◽  
Quanli Liu ◽  
Chen Gao ◽  
...  
Keyword(s):  
End Stage Renal Disease ◽  
Renal Fibrosis ◽  
Renal Tissue ◽  
Pathological Process ◽  
Unilateral Ureteral Obstruction ◽  
Butanol Extract ◽  
Effective Components ◽  
Tubulointerstitial Damage ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background: Renal fibrosis is a pathological process of progression from chronic kidney disease to end-stage renal disease, which threaten human health. Amygdalus mongolica is a traditional Chinese medicine, and our previous studies demonstrated that the n-butanol extract (BUT) and amygdalin extract (AMY) from its seeds, which are effective components of A. mongolica, can prevent renal fibrosis (RF). The present study was to investigate the exact mechanism of the protective effect of A. mongolica on RF. Methods: The RF rat model was established through unilateral ureteral obstruction (UUO). Biochemical indicators were measured, combined with histopathology of renal tissue, to evaluate the anti-RF effects of the extracts of A. mongolica. A serum metabonomic method based on UPLC-QTOF-MS was used to clarify the changes in the metabolic profile among the different groups. Results: We found that tubulointerstitial damage and fibrosis were significantly improved, metabolic perturbations were restored after treatment with BUT and AMY. Thirty-eight metabolites associated with RF progression and related to the regulation of arginine and proline metabolism, nicotinate and nicotinamide metabolism, histidine metabolism and pentose and glucuronate interconversions were identified. They were restored to levels similar to those observed in controls by treatment with AMY and BUT. Moreover, no significant differences in efficacy were observed between the BUT and AMY groups. Conclusions: The results demonstrated that antifibrotic effects of A. mongolica in rats with RF. It was the first to reveal the potential mechanisms of the renoprotective effects after treatment with BUT and AMY from A. mongolica.

Sign in / Sign up

Export Citation Format

Share Document