scholarly journals The genetic feature and virulence determinant of Highly Virulent Community-Associated MRSA ST338-SCCmec Vb in China

Author(s):  
Ye Jin ◽  
Wangxiao Zhou ◽  
Zhidong Yin ◽  
Shuntian Zhang ◽  
Yunbo Chen ◽  
...  
Viruses ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 875 ◽  
Author(s):  
Nanhua Chen ◽  
Mengxue Ye ◽  
Yucheng Huang ◽  
Shuai Li ◽  
Yanzhao Xiao ◽  
...  

Porcine reproductive and respiratory syndrome virus (PRRSV) causes huge economic loss to the global swine industry. Even though several control strategies have been applied, PRRS is still not effectively controlled due to the continuous emergence of new variants and limited cross-protection by current vaccines. During the routine epidemiological investigation in 2017, two PRRSV variants were identified from a severe abortion farm and a clinically healthy farm, respectively. The viruses were isolated and denominated as XJ17-5 and JSTZ1712-12. Genomic sequencing indicated that their genomes are both 14,960 bp in length sharing 99.45% nucleotide identity. Sequence alignments identified a discontinuous 30-amino-acid deletion and a continuous 120-amino-acid deletion in nsp2 of both isolates. Genome-based phylogenetic analysis confirmed that XJ17-5 and JSTZ1712-12 belong to the HP-PRRSV subtype but form a new branch with other isolates containing the same 150-amino-acid deletion in nsp2. Pathogenic analysis showed that XJ17-5 is highly virulent causing 60% mortality, while JSTZ1712-12 is avirulent for piglets. Furthermore, fragment comparisons identified 34-amino-acid differences between XJ17-5 and JSTZ1712-12 that might be associated with the distinct virulence. The identification of highly homologous HP-PRRSV variants with new genetic feature and distinct virulence contributes to further analyze the pathogenesis and evolution of PRRSV in the field.


1997 ◽  
Vol 2 (5) ◽  
pp. 482-487 ◽  
Author(s):  
Claudio Zuniga ◽  
Teresa Palau ◽  
Pilar Penin ◽  
Carlos Gamallo ◽  
Jose Antonio de Diego

Author(s):  
Mohammad Asgharzadeh ◽  
Jalil Rashedi ◽  
Behroz Mahdavi Poor ◽  
Hossein Samadi kafil ◽  
Hossein Moharram Zadeh ◽  
...  

: Nowadays, due to the incidence of specific strains of Mycobacterium tuberculosis and also increase the rate of drug resistant-TB mortality rate has elevated by this disease. Identification of common strains in the region as well as sources of transmission are essential to control the disease that this has been possible by using molecular epidemiology. In this survey, studies which have been carried out based on spoligotyping method in Muslim Middle East countries were considered to determine their role in control of TB. All studies conducted from 2005 to June 2016 were considered systematically in three electronic data bases and finally, 23 studies were selected. The average rate of clustering was 84% and the rate of recent transmission was variable from 21.7% to 92.4%. Incidence of Beijing strains was been rising in the considered countries. In Iran and Saudi Arabia which are immigration and labour-hosting countries, respectively, rapid transmittable strains and drug resistant Beijings were higher than other considered countries. Considering the incidence of highly virulent strains, due to the increase of immigration and people infected with HIV, tuberculosis, especially drug resistant form, the lack of close monitoring in the future will be induce trouble.


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