Yeast KRE genes provide evidence for a pathway of cell wall beta-glucan assembly.
1990 ◽
Vol 110
(5)
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pp. 1833-1843
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Keyword(s):
The Saccharomyces cerevisiae KRE1 gene encodes a Ser/Thr-rich protein, that is directed into the yeast secretory pathway, where it is highly modified, probably through addition of O-linked mannose residues. Gene disruption of the KRE1 locus leads to a 40% reduced level of cell wall (1----6)-beta-glucan. Structural analysis of the (1----6)-beta-glucan fraction, isolated from a strain with a krel disruption mutation, showed that it had an altered structure with a smaller average polymer size. Mutations in two other loci, KRE5 and KRE6 also lead to a defect in cell wall (1----6)-beta-glucan production and appear to be epistatic to KRE1. These findings outline a possible pathway of assembly of yeast cell wall (1----6)-beta-glucan.
1994 ◽
Vol 269
(49)
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pp. 31267-31274
Keyword(s):
1990 ◽
Vol 34
(4)
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pp. 660-662
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Keyword(s):
Keyword(s):
2019 ◽
Vol 84
(12-13)
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pp. 1513-1520
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2006 ◽
Vol 72
(11)
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pp. 7003-7012
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1984 ◽
Vol 30
(12)
◽
pp. 1437-1439
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