Presenilins: A novel link between intracellular calcium signaling and lysosomal function?
Keyword(s):
Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer’s disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FAD-associated PS mutations, which have been previously attributed to a function for PS in lysosomal acidification. Now, in this issue, Coen et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201201076) provide a series of results that challenge this idea and propose instead that presenilins play a role in calcium-mediated lysosomal fusion.
1994 ◽
Vol 269
(25)
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pp. 17104-17110
2001 ◽
pp. 242-248
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2005 ◽
Vol 80
(1)
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pp. 135-145
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2021 ◽
2015 ◽
Vol 56
(4)
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pp. 259-262
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