scholarly journals An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 ◽  
Vol 178 (6) ◽  
pp. 2249-2254 ◽  
Author(s):  
J L Flynn ◽  
J Chan ◽  
K J Triebold ◽  
D K Dalton ◽  
T A Stewart ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Interferon Gamma ◽  
Experimental Studies ◽  
Cell Mediated Immunity ◽  
Industrialized Countries ◽  
Mycobacterium Tuberculosis Infection ◽  
Ifn Gamma ◽  
Major Health Problem ◽  
Fatal Course ◽  
Reactive Nitrogen Intermediates

Tuberculosis, a major health problem in developing countries, has reemerged in recent years in many industrialized countries. The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate that T cell-mediated immunity plays an important role in resistance. The lymphokine interferon gamma (IFN-gamma) is thought to be a principal mediator of macrophage activation and resistance to intracellular pathogens. Mice have been developed which fail to produce IFN-gamma (gko), because of a targeted disruption of the gene for IFN-gamma. Upon infection with Mycobacterium tuberculosis, although they develop granulomas, gko mice fail to produce reactive nitrogen intermediates and are unable to restrict the growth of the bacilli. In contrast to control mice, gko mice exhibit heightened tissue necrosis and succumb to a rapid and fatal course of tuberculosis that could be delayed, but not prevented, by treatment with exogenous recombinant IFN-gamma.

scholarly journals Diagnosis of latent Mycobacterium tuberculosis infection: tuberculin test versus interferon-gamma release

2015 ◽  
Vol 48 (6) ◽  
pp. 724-730 ◽  
Author(s):  
Thaís Furtado Ferreira ◽  
Pollyanna da Fonseca Silva Matsuoka ◽  
Alcione Miranda dos Santos ◽  
Arlene de Jesus Mendes Caldas
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Interferon Gamma ◽  
Tuberculin Test ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

scholarly journals PERAN INTERFERON GAMMA PADA INFEKSI Mycobacterium tuberculosis

2017 ◽  
Vol 17 (2) ◽  
pp. 126-132
Author(s):  
Nur Wahyuniati
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Interferon Gamma ◽  
Morbidity Rate ◽  
High Morbidity ◽  
Th1 Cell ◽  
Major Health Problem ◽  
Major Health ◽  
High Morbidity Rate ◽  
Keywords Tuberculosis ◽  
Cellular Immune

Abstrak.Penyakit tuberkulosis masih tetap merupakan masalah kesehatan yang utama di dunia. Penyakit ini menyebabkan angka kesakitan yang tinggi pada jutaan penduduk dunia setiap tahunnya. Mycobacterium tuberculosis (M.Tb) memiliki kemampuan aktifitas replikasi dan metabolisme yang tinggi dan memiliki kemampuan untuk bertahan hidup di dalam fagosit profesional. Respon imun seluler sangat berperan penting untuk proses eliminasi M. Tb. Sel TH1 yang teraktivasi akan mengeluarkan interferon gamma yang akan mengaktivasi makrofag. Interferon gamma memiliki peran yang sangat penting dalam imunitas protektif terhadap infeksi M.Tb.(JKS 2017; 2: 131-137)Kata kunci: Tuberkulosis, Mycobacterium tuberculosis, respon T­H1,Interferon gammaAbstract. Tuberculosis remains a major health problem in the world. This disease causes a high morbidity rate in millions of the world's population each year. Mycobacterium tuberculosis (M.Tb) has high replication and metabolism activity and has the ability to survive in professional phagocytes. Cellular immune responses play an important role in the elimination process of M. Tb. The activated TH1 cell will secrete interferon gamma that leads to activation of macrophages. Interferon gamma has a very important role in protective immunity against infection M.Tb.(JKS 2017; 2: 131-137)Keywords: Tuberculosis, Mycobacterium tuberculosis, TH­1 response, Interferon gamma

scholarly journals The Role of N-Acetyl Sistein in Pulmonary Tuberculosis

2020 ◽  
Vol 6 (1) ◽  
pp. 27
Author(s):  
Resti Yudhawati ◽  
Nitya Prasanta
Keyword(s):  
Oxidative Stress ◽  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Respiratory Diseases ◽  
Antimicrobial Effect ◽  
Mycobacterium Tuberculosis Infection ◽  
Major Health Problem ◽  
Major Health ◽  
Mucolytic Agent

Pulmonary Tuberculosis is a chronic infection that caused by Mycobacterium tuberculosis (M.tb) infection and it is still the major health problem worldwide. Mycobacterium tuberculosis infection can induce oxidative stress. Some studies has proved that active TB patients have an association with excessive oxidative stress which causes glutathione (GSH) level decrease and free radicals increase. Glutathione (GSH) facilitates the control of M.TB intracellular bacterial growth in macrophages and has direct antimicrobial activity.  N-acetylcysteine (NAC) is thiol, a precursor of L-cysteine and glutathione synthesis (GSH) that has been used for decades as a mucolytic agent in the treatment of respiratory diseases. Some studies report beneficial role of NAC as immunomodulator, besides NAC also has anti-inflammatory and antimicrobial effect in TB management.

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