scholarly journals THE ETIOLOGY OF ACUTE UPPER RESPIRATORY INFECTION (COMMON COLD)

1931 ◽  
Vol 53 (4) ◽  
pp. 447-470 ◽  
Author(s):  
Perrin H. Long ◽  
James A. Doull ◽  
Janet M. Bourn ◽  
Emily McComb

Experimental upper respiratory infections similar to "common colds" were transmitted singly and in series through two and four passages in nine out of fifteen persons, by intransal inoculations with bacteria-free filtrates of nasopharyngeal washings obtained from individuals ill with natural "colds." These observations conform with those reported by previous workers and lend further support to the view that the incitant of the "common cold" is a filtrable virus.

1930 ◽  
Vol 52 (5) ◽  
pp. 701-716 ◽  
Author(s):  
A. R. Dochez ◽  
Gerald S. Shibley ◽  
Katherene C. Mills

1. Chimpanzees are highly suitable animals for the experimental study of human upper respiratory infections. 2. Human colds have been successfully transmitted to apes and human volunteers in 44 per cent of instances tried by means of filtered nasal washings obtained from colds. 3. Certain types of infectious colds are caused by a filtrable agent.


1979 ◽  
Vol 1 (3) ◽  
pp. 76-76

Children with upper respiratory infections who had streptococci excluded by culture were treated with either of the above agents or a placebo. There was no difference among the regimes in overall outcome. Comments: This study would seem superfluous but for the continued promiscuous use of the antibiotics for viral disease in hopes of "preventing complications." It doesn't work. I wish that it did. (R.H.R.)


1996 ◽  
Vol 17 (1) ◽  
pp. 12-17
Author(s):  
Murray L. Katcher

Separately or in combination, antihistamines, decongestants, antitussives, and expectorants are used to treat the cough and rhinitis symptoms of the common cold and of allergies. Each year, Americans spend 1 to 2 billion dollars on cough and cold remedies and lose more than 26 million school days and 23 million work days because of rhinitis and associated symptoms. Studies have shown that antihistamines and decongestants are efficacious in the treatment of allergy symptoms, but the results of studies are mixed regarding their efficacy in the treatment of symptoms of the common cold, and studies show no effect in prevention or treatment of otitis media. Some review articles and consensus opinions do not recommend the use of these drugs in the common cold (especially in preschool children), although some studies have demonstrated symptomatic relief, and physicians continue to prescribe or recommend these drugs for respiratory illness more than 36 million times annually. The Common Cold More than 200 million cases of acute upper respiratory infection (URI) occur each year in the United States, and more than 75 million are seen by physicians. URIs account for 23 million missed work days and 26 million missed school days. This is the second most common diagnosis made by office-based pediatricians, second only to otitis media.


PEDIATRICS ◽  
1955 ◽  
Vol 15 (3) ◽  
pp. 334-336
Author(s):  
Sidney S. Samuels

THE DIAGNOSIS of non-suppurative, secretory otitis media has been made much more frequently in recent years than it was prior to 1950. This increase has been noticed in children many more times than in adults, as pointed out by Robison and Nicholas. The disease is much more commonly found because of increased vigilance some otologists believe, as does Suehs, since the entity was reviewed and clarified by the brilliant work of Hoople in that year. However, there are undoubtedly other factors contributing to the greater incidence of this entity, such as the increased use of antibiotics in upper respiratory infections, including otitis media; an increase in the number of so-called virus infections; the greater prevalence of allergic diathesis; increased air travel; and, as Lindsay states, the swing of time pendulum toward extreme conservatism in recommending removal of tonsils and adenoids, a tendency resulting partly from a sense of security afforded by antibiotic therapy. The condition has received more of the attention it merits lately from that group of practitioners who are first in contact with the patients, namely the pediatrician and general practitioner who attend the acutely ill child. For usually the actual onset of the illness is acute, an otitis media occurring during an acute upper respiratory infection or as an acute otitis media following such an illness. The former need not even reach the stage where it is definitely recognized, its progress being halted by the antibiotic treatment administered. The attention of the attending physiciain is focused upon the middle ear in the younger child, either by the presence of pain in the affected ear, or by the abnormal appearance of the tympanic membrane, or both.


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