scholarly journals OBSERVATIONS ON THE BLOOD CYTOLOGY IN EXPERIMENTAL SYPHILIS

1934 ◽  
Vol 59 (6) ◽  
pp. 711-720 ◽  
Author(s):  
Paul D. Rosahn ◽  
Louise Pearce ◽  
Albert E. Casey
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
Cell Count ◽  
Normal Control ◽  
Lymphocyte Count ◽  
White Cell Count ◽  
White Cell ◽  
Monocyte Count ◽  
Total White Cell Count ◽  
The Mean

Weekly observations were made on the blood cytology of seven syphilitic and nine normal control rabbits. Each animal was examined seven times prior to and fifteen times after inoculation of the experimental group. Comparisons were made between the mean blood cell values obtained from all counts on the experimental and control groups in the preinoculation and postinoculation periods. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the preinoculation mean values observed in the same group in the following respects: higher total white cell count, platelet count, neutrophil count, and monocyte count, and lower lymphocyte count. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the mean blood cell formula of the normal control group in the same time interval in the following respects: higher total white cell count, platelet count, neutrophil and monocyte counts, and lower lymphocyte count. From these results it was concluded that during the period of disease activity, the blood cytology of rabbits infected with Tr. pallidum is characterized by an increase in the total white cell count, the platelet, neutrophil, and monocyte counts, and a decrease in the lymphocyte count from normal values. These changes were statistically significant.

Leucocytes and Thrombosis

1973 ◽  
Vol 30 (03) ◽  
pp. 541-546
Author(s):  
D. C Banks ◽  
J. R. A Mitchell
Keyword(s):  
Myocardial Infarction ◽  
Platelet Count ◽  
Cell Count ◽  
White Cell Count ◽  
Diagnostic Value ◽  
White Cell ◽  
Recent Myocardial Infarction ◽  
Marked Elevation ◽  
Idiopathic Thrombocytopenia ◽  
The Mean

SummaryNormal white cell adhesiveness was found in a group of patients with idiopathic thrombocytopenia in whom the mean platelet count was 34,000 per cu. mm.Marked elevation of white cell adhesiveness was observed after splenectomy. This did not correlate with changes in the white cell count but did parallel the increase in platelet count and adhesiveness.White cell adhesiveness was increased in patients with a recent myocardial infarction. As it was also increased in patients with other acute illnesses and was normal in patients with old myocardial infarcts, the test is not of diagnostic value in thrombotic disease.

Parameters That Contribute to Hearing Loss in Cml Patients

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4455-4455
Author(s):  
Amma A. Benneh ◽  
Edeghonghon Olayemi ◽  
Kenneth Baidoo ◽  
David Nana Adjei
Keyword(s):  
Hearing Loss ◽  
Platelet Count ◽  
Haemoglobin Level ◽  
Cell Count ◽  
White Cell Count ◽  
White Cell ◽  
Fish Analysis ◽  
Total White Cell Count ◽  
Sokal Score ◽  
Level Of Significance

Abstract Abstract 4455 Background: Chronic Myeloid leukaemia (CML) is a clonal disease that results from an acquired genetic change in a pluripotential haemopoietic stem cell. Hearing loss is a rare complication of CML. The most probable cause of the hearing loss in CML has been attributed to hyperleukostasis rather than leukaemic infiltration as seen in other leukaemias. This supported by the fact that hearing loss can be reversed in some patients if leukapheresis is done early. Patients and Methods: This retrospective study was conducted at the Korle-Bu Teaching Hospital, Accra, Ghana. Study included adult patients diagnosed with (CML) over a five year period from January 2007 to December 2011 who presented with hearing loss. Seven of them presented with hearing loss. Diagnosis of CML was made by a bone marrow aspirate and confirmed with Fluorescence in situ hybridization (FISH) analysis for Philadelphia chromosome. Medical records of cases were analyzed for their demographic characteristics and clinical features. Haemoglobin levels, total white cell count at presentation and platelet count were also obtained from their full blood counts. Correlation between hearing loss and parameters such as age, sex, total white cell count at presentation, level of haemoglobin, platelet count and results of FISH analysis on presentation were analysed and level of significance obtained using Pearson's correlation. Results: Eight-three patients were diagnosed with CML over the period and 8.4% (7) presented with hearing loss. Six of the patients were males and there was one female. Significant level of significance was found between hearing loss and white cell count (p=0.043), haemoglobin level (p=0.024), sokal score (p=0.001) and results of FISH at diagnosis (p=0.039). Level of significance was 5%. Conclusion: There was significant correlation between hearing loss and parameters such as white cell count at presentation, haemoglobin level, sokal score and results of FISH at diagnosis in this study. These factors played a role towardsthe loss of hearing of these CML patients in the study. Disclosures: Baidoo: GSK: Speakers Bureau.

Effects of various steroids on the thymus, spleen, ventral prostate and seminal vesicles in old orchidectomized rats

1987 ◽  
Vol 113 (1) ◽  
pp. 51-55 ◽  
Author(s):  
F. T. A. Fitzpatrick ◽  
B. D. Greenstein
Keyword(s):  
Cell Count ◽  
White Cell Count ◽  
Seminal Vesicles ◽  
White Cell ◽  
Male Rats ◽  
Ventral Prostate ◽  
Total White Cell Count ◽  
Cell Counts ◽  
Thymus Weight ◽  
Accessory Sex Organs

ABSTRACT The effects of several steroids on the regenerating thymus in ageing male rats have been studied. Rats aged from 12 to 15 months were orchidectomized and 7 days later implanted s.c. with silicone elastomer tubing containing 25 mg testosterone, 5α-dihydrotestosterone (DHT), oestradiol, progesterone or corticosterone. One group of rats received an empty implant. Thirty days later the rats were killed and the thymus, spleen, ventral prostate and seminal vesicles weighed and retained for histology. Whole blood was taken for total and differential white cell counts; plasma was prepared for radioimmunoassay of testosterone, oestradiol, progesterone and corticosterone. After orchidectomy only, a multilobular thymus was present, and histologically the tissue appeared healthy. In testosterone- and oestradiol-treated rats, thymus weight was reduced to about 50% of that in untreated animals. Histologically, much of the thymus taken at autopsy was fat and what remained was poorly organized and contained a much lower density of thymocytes. The total white cell count was significantly reduced in these animals, the effect appearing to be predominantly on lymphocytes. Although treatment with DHT also resulted in a lower mean thymus weight than that of orchidectomized animals, histologically the tissue appeared similar to that of the untreated castrated animals. In rats treated with DHT, the total white cell count was significantly higher than in testosterone-implanted rats. Both progesterone and corticosterone implants resulted in significantly smaller mean thymus weights, although these steroids were not as potent as testosterone or oestradiol. Corticosterone, but not progesterone, appeared to cause a significant reduction in circulating lymphocytes. Dihydrotestosterone possessed only half the potency of testosterone in restoring the weights of the accessory sex organs. Serum concentrations of testosterone in orchidectomized old rats were 0·33 ± 0·02 nmol/l and in testosterone-implanted rats 4·8 ± 0·4 nmol/l. These results raise the possibility that testosterone and oestradiol may have caused atrophy of the thymus, while DHT may have retarded regeneration of the thymus without any atrophic effect. It remains to be seen whether the different responses between testosterone and DHT, in both the thymus and accessory sex organs, are due to differences in intrinsic action or differences in the metabolism of the steroids. J. Endocr. (1987) 113, 51–55

Extracorporeal photopheresis in Sézary syndrome: hematologic parameters as predictors of response

Blood ◽  
2001 ◽  
Vol 98 (5) ◽  
pp. 1298-1301 ◽  
Author(s):  
Alun V. Evans ◽  
Blair P. Wood ◽  
Julia J. Scarisbrick ◽  
Elizabeth A. Fraser-Andrews ◽  
Sue Chinn ◽  
...  
Keyword(s):  
Cell Count ◽  
Peripheral Blood ◽  
White Cell Count ◽  
White Cell ◽  
Response Analysis ◽  
Extracorporeal Photopheresis ◽  
Skin Score ◽  
Total White Cell Count ◽  
Cell Counts ◽  
T Cell Clone

Data were analyzed from 23 patients with Sézary syndrome (defined by erythroderma, more than 10% circulating atypical mononuclear cells, and peripheral blood T-cell clone) undergoing monthly extracorporeal photopheresis as the sole therapy for up to 1 year. The cohort showed a significant reduction of skin scores during treatment (P = .001). Thirteen patients (57%) achieved a reduction in skin score greater than 25% from baseline at 3, 6, 9, or 12 months (responders). Reduction in skin score correlated with reduction in the Sézary cell count as a percentage of total white cell count (P = .03). Responders and nonresponders were compared. None of the measured parameters was significantly different between the 2 groups. It was assessed whether any of the baseline parameters predicted outcome. A higher baseline lymphocyte count was significantly associated with a decrease in skin score at 6 months (P < .05). A higher baseline Sézary cell count as a percentage of total white cell count predicted a subject was more likely to be a responder after 6 months of treatment (P = .021). No other parameters predicted responder status. These data show that the modest falls in CD4, CD8, and Sézary cell counts were seen in all patients and might have resulted from lymphocyte apoptosis. This mechanism could explain the more favorable response seen in patients with higher percentages of Sézary cells in the peripheral blood. Alternatively, minimum tumor burden might be required for the induction of a cytotoxic response. Analysis of tumor-specific cytotoxic T cells is needed to investigate these possibilities further.

scholarly journals Hyperleukocytosis and leukostasis: common features of childhood chronic myelogenous leukemia

Blood ◽  
1984 ◽  
Vol 63 (5) ◽  
pp. 1230-1234 ◽  
Author(s):  
JM Rowe ◽  
MA Lichtman
Keyword(s):  
Cell Count ◽  
Chronic Myelogenous Leukemia ◽  
White Cell Count ◽  
White Cell ◽  
Myelogenous Leukemia ◽  
Time Interval ◽  
Usual Type ◽  
Cell Counts ◽  
The Mean ◽  
The University

Abstract Ten patients under 20 yr of age with the usual (adult) type of chronic myelogenous leukemia (CML) were seen at the University of Rochester Medical Center from 1970 to 1982. The mean white cell count in these 10 patients at presentation was 360,000/microliter, as compared to a mean of 137,000/microliter in 80 CML patients over 20 yr of age seen during the same time interval (p less than 0.02). Analyses of all 90 cases revealed a significant decrease in the average leukocyte count at presentation with increasing age. The childhood cases also had a significantly higher proportion of blood blasts, promyelocytes, and myelocytes than did the adult subjects (p less than 0.01). Signs of leukostasis were present in 12% of adult cases as compared to 60% of the 10 childhood cases, and in these 6 subjects, the mean white cell count was 510,000/microliter. In these 6 patients, leukapheresis and/or chemical therapy was initiated rapidly, and this was followed by complete resolution of the clinical signs of leukostasis. A review of the literature from 1960 to 1982 identified 61 childhood cases that were reported with the usual type of CML. In this group, the frequency of hyperleukocytosis and the distribution of white cell counts corresponded very closely to the 10 cases studied at the University of Rochester. Thus, the usual type of CML presenting in childhood differs from that of adults in that hyperleukocytosis, blood granulocyte immaturity, and leukostatic central nervous system, retinal, and respiratory signs are significantly more common and extreme and merit rapid cytoreductive treatment.

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