Leucocytes and Thrombosis

SummaryNormal white cell adhesiveness was found in a group of patients with idiopathic thrombocytopenia in whom the mean platelet count was 34,000 per cu. mm.Marked elevation of white cell adhesiveness was observed after splenectomy. This did not correlate with changes in the white cell count but did parallel the increase in platelet count and adhesiveness.White cell adhesiveness was increased in patients with a recent myocardial infarction. As it was also increased in patients with other acute illnesses and was normal in patients with old myocardial infarcts, the test is not of diagnostic value in thrombotic disease.

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OBSERVATIONS ON THE BLOOD CYTOLOGY IN EXPERIMENTAL SYPHILIS

Journal of Experimental Medicine ◽

10.1084/jem.59.6.711 ◽

1934 ◽

Vol 59 (6) ◽

pp. 711-720 ◽

Cited By ~ 5

Author(s):

Paul D. Rosahn ◽

Louise Pearce ◽

Albert E. Casey

Keyword(s):

Platelet Count ◽

Blood Cell ◽

Cell Count ◽

Normal Control ◽

Lymphocyte Count ◽

White Cell Count ◽

White Cell ◽

Monocyte Count ◽

Total White Cell Count ◽

The Mean

Weekly observations were made on the blood cytology of seven syphilitic and nine normal control rabbits. Each animal was examined seven times prior to and fifteen times after inoculation of the experimental group. Comparisons were made between the mean blood cell values obtained from all counts on the experimental and control groups in the preinoculation and postinoculation periods. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the preinoculation mean values observed in the same group in the following respects: higher total white cell count, platelet count, neutrophil count, and monocyte count, and lower lymphocyte count. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the mean blood cell formula of the normal control group in the same time interval in the following respects: higher total white cell count, platelet count, neutrophil and monocyte counts, and lower lymphocyte count. From these results it was concluded that during the period of disease activity, the blood cytology of rabbits infected with Tr. pallidum is characterized by an increase in the total white cell count, the platelet, neutrophil, and monocyte counts, and a decrease in the lymphocyte count from normal values. These changes were statistically significant.

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Haemostatic Variables and the Outcome of Myocardial Infarction

Thrombosis and Haemostasis ◽

10.1055/s-0038-1665316 ◽

1983 ◽

Vol 50 (04) ◽

pp. 800-803 ◽

Cited By ~ 89

Author(s):

A P Haines ◽

D Howarth ◽

W R S North ◽

Eva Goldenberg ◽

Yvonne Stirling ◽

...

Keyword(s):

Myocardial Infarction ◽

Creatine Kinase ◽

Cell Count ◽

White Cell Count ◽

White Cell ◽

Predictors Of Outcome ◽

Clinical Predictors ◽

Α2 Macroglobulin ◽

Laboratory Variables ◽

The Mean

SummaryIn a study of 272 patients with myocardial infarction (MI) the 68 who died within 1 year had significantly higher levels of factor VIIIR:Ag, factor VIII:C, fibrinogen, α1 antitrypsin and α2 macroglobulin than those who survived. The mean white cell count (WCC) and peak creatine kinase (CK) were also significantly higher in those who died compared with the survivors. There was considerable intercorrelation between many of the haemostatic variables, WCC and CK as well as between many of the clinical predictors of outcome and the laboratory variables. The differences in haemostatic variables between those who died and those who survived may merely reflect the size of the infarct; alternatively, the haemostatic system may influence prognosis following an MI.

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The relationship of white cell count, platelet count, and hematocrit to cigarette smoking in adolescents: the Oslo Youth Study.

Circulation ◽

10.1161/01.cir.72.5.971 ◽

1985 ◽

Vol 72 (5) ◽

pp. 971-974 ◽

Cited By ~ 32

Author(s):

G S Tell ◽

R H Grimm ◽

O D Vellar ◽

L Theodorsen

Keyword(s):

Platelet Count ◽

Cigarette Smoking ◽

Cell Count ◽

White Cell Count ◽

White Cell ◽

Youth Study ◽

Relationship Of ◽

The Relationship

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The diagnostic value of white cell count, C-reactive protein and bilirubin in acute appendicitis and its complications

Annals of The Royal College of Surgeons of England ◽

10.1308/003588413x13511609957371 ◽

2013 ◽

Vol 95 (3) ◽

pp. 215-221 ◽

Cited By ~ 28

Author(s):

I G Panagiotopoulou ◽

D Parashar ◽

R Lin ◽

S Antonowicz ◽

AD Wells ◽

...

Keyword(s):

Acute Appendicitis ◽

Diagnostic Accuracy ◽

Cell Count ◽

Inflammatory Markers ◽

White Cell Count ◽

Perforated Appendicitis ◽

Diagnostic Value ◽

White Cell ◽

C Reactive Protein ◽

Reactive Protein

Introduction Inflammatory markers such as white cell count (WCC) and C-reactive protein (CRP) and, more recently, bilirubin have been used as adjuncts in the diagnosis of appendicitis. The aim of this study was to determine the diagnostic accuracy of the above markers in acute and perforated appendicitis as well as their value in excluding the condition. Methods A retrospective analysis of 1,169 appendicectomies was performed. Patients were grouped according to histological examination of appendicectomy specimens (normal appendix = NA, acute appendicitis = AA, perforated appendicitis = PA) and preoperative laboratory test results were correlated. Receiver operating characteristic (ROC) curve area analysis (area under the curve [AUC]) was performed to examine diagnostic accuracy. Results ROC analysis of all laboratory variables showed that no independent variable was diagnostic for AA. Good diagnostic accuracy was seen for AA when all variables were combined (WCC/CRP/bilirubin combined AUC: 0.8173). In PA, the median CRP level was significantly higher than that of AA (158mg/l vs 30mg, p<0.0001). CRP also showed the highest sensitivity (100%) and negative predictive value (100%) for PA. CRP had the highest diagnostic accuracy in PA (AUC: 0.9322) and this was increased when it was combined with WCC (AUC: 0.9388). Bilirubin added no diagnostic value in PA. Normal levels of WCC, CRP and bilirubin could not rule out appendicitis. Conclusions CRP provides the highest diagnostic accuracy for PA. Bilirubin did not provide any discriminatory value for AA and its complications. Normal inflammatory markers cannot exclude appendicitis, which remains a clinical diagnosis.

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What is the diagnostic value of white cell count, neutrophil count, C-reactive protein in acute and perforated appendicitis?

International Journal of Surgery ◽

10.1016/j.ijsu.2014.08.232 ◽

2014 ◽

Vol 12 ◽

pp. S96-S97

Author(s):

Kevin Cao ◽

Jessica Ng ◽

Zuhaib Keekeebhai

Keyword(s):

Cell Count ◽

Neutrophil Count ◽

White Cell Count ◽

Perforated Appendicitis ◽

Diagnostic Value ◽

White Cell ◽

C Reactive Protein ◽

Reactive Protein

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Hyperleukocytosis and leukostasis: common features of childhood chronic myelogenous leukemia

Blood ◽

10.1182/blood.v63.5.1230.1230 ◽

1984 ◽

Vol 63 (5) ◽

pp. 1230-1234 ◽

Cited By ~ 38

Author(s):

JM Rowe ◽

MA Lichtman

Keyword(s):

Cell Count ◽

Chronic Myelogenous Leukemia ◽

White Cell Count ◽

White Cell ◽

Myelogenous Leukemia ◽

Time Interval ◽

Usual Type ◽

Cell Counts ◽

The Mean ◽

The University

Abstract Ten patients under 20 yr of age with the usual (adult) type of chronic myelogenous leukemia (CML) were seen at the University of Rochester Medical Center from 1970 to 1982. The mean white cell count in these 10 patients at presentation was 360,000/microliter, as compared to a mean of 137,000/microliter in 80 CML patients over 20 yr of age seen during the same time interval (p less than 0.02). Analyses of all 90 cases revealed a significant decrease in the average leukocyte count at presentation with increasing age. The childhood cases also had a significantly higher proportion of blood blasts, promyelocytes, and myelocytes than did the adult subjects (p less than 0.01). Signs of leukostasis were present in 12% of adult cases as compared to 60% of the 10 childhood cases, and in these 6 subjects, the mean white cell count was 510,000/microliter. In these 6 patients, leukapheresis and/or chemical therapy was initiated rapidly, and this was followed by complete resolution of the clinical signs of leukostasis. A review of the literature from 1960 to 1982 identified 61 childhood cases that were reported with the usual type of CML. In this group, the frequency of hyperleukocytosis and the distribution of white cell counts corresponded very closely to the 10 cases studied at the University of Rochester. Thus, the usual type of CML presenting in childhood differs from that of adults in that hyperleukocytosis, blood granulocyte immaturity, and leukostatic central nervous system, retinal, and respiratory signs are significantly more common and extreme and merit rapid cytoreductive treatment.

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Hematologic Remission of Chronic Myelogenous Leukemia after Treatment with Imatinib Includes Normalization of the Red Cell Distribution Width.

Blood ◽

10.1182/blood.v106.11.4882.4882 ◽

2005 ◽

Vol 106 (11) ◽

pp. 4882-4882

Author(s):

Joel David Bessman ◽

Maria Montoya

Keyword(s):

Platelet Count ◽

Cell Count ◽

Chronic Myelogenous Leukemia ◽

White Cell Count ◽

White Cell ◽

Myelogenous Leukemia ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width

Abstract After treatment with imatinib, the majority of patients with chronic myelogenous leukemia (CML) achieve hematologic remission. This includes normalization of blood counts (red cells, white cells, and platelets) normalization of the white cell differential, and disappearance of abnormal immature cells from the peripheral blood. However, abnormal erythropoiesis may be more subtle than abnormal red cell counts. We reviewed two other indices of erythropoiesis, the mean cell volume (MCV) and the red cell distribution width (RDW). We studied 15 patients with a diagnosis of CML confirmed by BCR-ABL, in whom the first-line therapy was imatinib. Treatment dosage varied from 400 – 800 mg/day. Pre-treatment, all patients had an elevated white cell count, 14 of 15 had a low hemoglobin, and 11 of 15 had an abnormal high platelet count. None had an abnormal MCV (mean, 91.3, range 82 – 97), and 13 of 15 had an abnormal RDW (mean 16.2, range 14.1 – 19.2). After treatment was started, all 15 achieved a normal white cell count, hemoglobin, and platelet count within 3 months. All continued to have a normal MCV, with no apparent change (mean 92.1, range 82 – 98). However, after treatment 14 of 15 developed a normal RDW (mean 13.7, range 12.0 – 15.2). The RDW progressively declined during the first 3 months after treatment and reached an asymptote at that time. We conclude that hematopoiesis normalizes qualitatively as well as quantitatively after successful imatinib therapy of CML. Future study will determine whether an isolated elevated RDW will predict relapse or briefer duration of remission.

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