Treatment‐Mediated Changes in Human Immunodeficiency Virus (HIV) Type 1 RNA and CD4 Cell Counts as Predictors of Weight Growth Failure, Cognitive Decline, and Survival in HIV‐Infected Children

Background. Growth failure is a common feature of children with human immunodeficiency virus (HIV) infection. Malnutrition increases mortality and may impair the response to antiretroviral treatment.Objective. Our objective was to describe the prevalence of stunting, underweight, and wasting in HIV-infected children in south India and to assess the utility of these parameters in predicting immune status.Methodology. In this cross-sectional study, anthropometric measurements and CD4 counts were performed on 231 HIV-infected children. scores for height for age, weight for age, and weight for height were correlated with CD4 cell counts and receiver operating characteristic curves plotted.Results. Prevalence of underweight was 63%, stunting 58%, and wasting 16%, respectively. 33–45% of children were moderately or severely malnourished even at CD4 >25%; sensitivity and specificity of stunting or underweight to predict HIV disease severity was low.Conclusions. Undernutrition and stunting are common among HIV-infected children at all stages of the disease in India. Early and aggressive nutritional intervention is required, if long-term outcomes are to be improved.

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Detection of Infectious Immune Complexes in Human Immunodeficiency Virus Type 1 (DIV-l) Infections: Correlation with Plasma Viremia and CD4 Cell Counts

The Journal of Infectious Diseases ◽

10.1093/infdis/164.4.765 ◽

1991 ◽

Vol 164 (4) ◽

pp. 765-769 ◽

Cited By ~ 11

Author(s):

S. A. Fiscus ◽

E. B. Wallmark ◽

J. D. Folds ◽

J. Fryer ◽

C. M. van der Horst

Keyword(s):

Human Immunodeficiency Virus ◽

Human Immunodeficiency Virus Type ◽

Virus Type ◽

Immune Complexes ◽

Plasma Viremia ◽

Cell Counts ◽

Cd4 Cell Counts ◽

Immunodeficiency Virus ◽

Cd4 Cell

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Brucella abortus conjugated with a peptide derived from the V3 loop of human immunodeficiency virus (HIV) type 1 induces HIV-specific cytotoxic T-cell responses in normal and in CD4+ cell-depleted BALB/c mice.

Journal of Virology ◽

10.1128/jvi.70.5.3084-3092.1996 ◽

1996 ◽

Vol 70 (5) ◽

pp. 3084-3092 ◽

Cited By ~ 20

Author(s):

C Lapham ◽

B Golding ◽

J Inman ◽

R Blackburn ◽

J Manischewitz ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Brucella Abortus ◽

Cytotoxic T Cell ◽

V3 Loop ◽

Cell Responses ◽

Immunodeficiency Virus ◽

Hiv Type 1 ◽

Cytotoxic T Cell Responses ◽

Cd4 Cell

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Safety, tolerance, and efficacy of atevirdine in asymptomatic human immunodeficiency virus-infected individuals.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.40.11.2664 ◽

1996 ◽

Vol 40 (11) ◽

pp. 2664-2668 ◽

Cited By ~ 2

Author(s):

A M Been-Tiktak ◽

I Williams ◽

H M Vrehen ◽

J Richens ◽

D Aldam ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Transcriptase Inhibitor ◽

Viral Loads ◽

Nonnucleoside Reverse Transcriptase Inhibitor ◽

Cell Counts ◽

Cd4 Cell Counts ◽

Immunodeficiency Virus ◽

Reverse Transcriptase Inhibitor ◽

Cd4 Cell ◽

Hiv 1

Atevirdine is a nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). In this study we investigated the effect of atevirdine in asymptomatic antiretroviral naive HIV-infected patients with CD4+ cell counts of between 200 and 750 cells per mm3. Patients were randomized to receive 600 mg of atevirdine (n = 15) or a placebo (n = 15) three times a day for 12 weeks. There was no statistically significant effect of atevirdine on viral loads (HIV p24 antigen and HIV-1 RNA levels by PCR) or CD4+ cell counts. The data do not support the use of atevirdine as a monotherapy in the treatment of HIV-infected patients.

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