On the Photochemical Degradation of 2,4-Dichlorophenoxyacetic Acid and Structurally Related Compounds in the Presence and Absence of Riboflavin

1956 ◽  
Vol 118 (2) ◽  
pp. 133-136 ◽  
Author(s):  
Gordon R. Bell
Keyword(s):  
Dichlorophenoxyacetic Acid ◽  
Photochemical Degradation ◽  
Presence And Absence ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
Related Compounds

scholarly journals Bisphenol A promotes stress granule assembly and modulates the integrated stress response

2019 ◽  
Author(s):  
Marta M. Fay ◽  
Daniella Columbo ◽  
Cecelia Cotter ◽  
Chandler Friend ◽  
Shawna Henry ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruption ◽  
Acute Stress ◽  
Dichlorophenoxyacetic Acid ◽  
High Dose ◽  
Structural Homology ◽  
Relevant Dose ◽  
The Common ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
Related Compounds

AbstractBisphenol-A (BPA) is a ubiquitous precursor of polycarbonate plastics that is found in the blood and serum of >92% of Americans. While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are unclear. Here, we demonstrate that high-dose BPA causes stress granules (SGs) in human cells. A common estrogen derivative, β-estradiol, does not trigger SGs, indicating the mechanism of SG induction is not via the ER pathway. We also tested other structurally related environmental contaminants including the common BPA substitutes BPS and BPF, the industrial chemical 4-nonylphenol (4-NP) and structurally related compounds 4-EP and 4-VP, and the pesticide 2,4-dichlorophenoxyacetic acid (2,4-D). The variable results from these related compounds suggest that structural homology is not a reliable predictor of the capacity of a compound to cause SGs. Also, we demonstrate that BPA acts primarily through the PERK pathway to generate canonical SGs. Finally, we show that chronic exposure to a low physiologically relevant dose of BPA disrupts SG assembly by inhibiting SGs upon additional acute stress. Our work identifies additional effects of BPA beyond endocrine disruption that may have consequences for human health.

scholarly journals Bisphenol A promotes stress granule assembly and modulates the integrated stress response

Biology Open ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. bio057539
Author(s):  
Marta M. Fay ◽  
Daniella Columbo ◽  
Cecelia Cotter ◽  
Chandler Friend ◽  
Shawna Henry ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Translational Control ◽  
Acute Stress ◽  
Dichlorophenoxyacetic Acid ◽  
High Dose ◽  
Translation Inhibition ◽  
Relevant Dose ◽  
The Common ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
Related Compounds

ABSTRACTBisphenol-A (BPA) is a ubiquitous precursor of polycarbonate plastics that is found in the blood and serum of >92% of Americans. While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are unclear. Here, we demonstrate that high-dose BPA causes stress granules (SGs) in human cells. A common estrogen derivative, β-estradiol, does not trigger SGs, indicating the mechanism of SG induction is not via the ER pathway. We also tested other structurally related environmental contaminants including the common BPA substitutes BPS and BPF, the industrial chemical 4-nonylphenol (4-NP) and structurally related compounds 4-EP and 4-VP, as well as the pesticide 2,4-dichlorophenoxyacetic acid (2,4-D). The variable results from these related compounds suggest that structural homology is not a reliable predictor of the capacity of a compound to cause SGs. Also, we demonstrate that BPA acts primarily through the PERK pathway to generate canonical SGs. Finally, we show that chronic exposure to a low physiologically relevant dose of BPA suppresses SG assembly upon subsequent acute stress. Interestingly, this SG inhibition does not affect phosphorylation of eIF2α or translation inhibition, thus uncoupling the physical assembly of SGs from translational control. Our work identifies additional effects of BPA beyond endocrine disruption that may have consequences for human health.

In Vitro Shoot Regeneration from Callus Derived from Marubakaido Apple Rootstock under Different Aluminium Concentrations

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 460e-460 ◽  
Author(s):  
Marisa F. de Oliveira ◽  
Gerson R. de L. Fortes ◽  
João B. da Silva
Keyword(s):  
Shoot Regeneration ◽  
Dichlorophenoxyacetic Acid ◽  
Apple Rootstock ◽  
Under Five ◽  
Significant Difference ◽  
Previously Treated ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
In Vitro Shoot Regeneration

The aim of this work was to evaluate the organogenesis of Marubakaido apple rootstock under different aluminium concentratons. The explants were calli derived from apple internodes treated with either 2,4-dichlorophenoxyacetic acid or pichloram at 0.5 and 1.0 μM and under five different aluminium concentrations (0, 5, 10, 15, 20 mg/L). These calli were then treated with aluminium at 0, 5, 10, 15, and 20 mg/L. It was observed shoot regeneration only for those calli previously treated with pichloram. There were no significant difference among the aluminium concentrations.

Sign in / Sign up

Export Citation Format

Share Document