scholarly journals Voriconazole-Induced QT Interval Prolongation and Ventricular Tachycardia: A Non--Concentration-Dependent Adverse Effect

2004 ◽  
Vol 39 (6) ◽  
pp. e49-e52 ◽  
Author(s):  
Y. Alkan ◽  
W. E. Haefeli ◽  
J. Burhenne ◽  
J. Stein ◽  
I. Yaniv ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Ventricular Tachycardia ◽  
Qt Interval ◽  
Interval Prolongation ◽  
Qt Interval Prolongation

Extreme QT Interval Prolongation and Helicoid Ventricular Tachycardia (Torsade de Pointes) in Non-ST-Elevation Acute Coronary Syndrome

2012 ◽  
Vol 65 (3) ◽  
pp. 294-296
Author(s):  
Montse Vilaseca-Corbera ◽  
Gabriel Vázquez-Oliva ◽  
Cristina Campoamor-Cela ◽  
Alberto Zamora-Cervantes ◽  
Joan Bassanyanes-Vilarrasa ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Ventricular Tachycardia ◽  
Qt Interval ◽  
Torsade De Pointes ◽  
Interval Prolongation ◽  
Coronary Syndrome ◽  
Qt Interval Prolongation ◽  
St Elevation ◽  
Elevation Acute Coronary Syndrome

Polymorphic ventricular tachycardias including torsade de pointes

ESC CardioMed ◽  
2018 ◽  
pp. 2293-2298
Author(s):  
L. Brent Mitchell
Keyword(s):  
Ventricular Tachycardia ◽  
Qt Interval ◽  
Torsade De Pointes ◽  
Term Treatment ◽  
Heart Disorder ◽  
Interval Prolongation ◽  
Cardioverter Defibrillator ◽  
Qt Interval Prolongation ◽  
Long Term Treatment

Polymorphic ventricular tachycardia (PMVT) is a rapid ventricular tachycardia in which the QRS complexes vary in coupling interval, morphology, and axis on a beat-to-beat basis. PMVT occurs in two distinct forms: PMVT without QT interval prolongation and PMVT with QT interval prolongation. The two types differ in important ways with respect to their differential diagnosis and treatment. PMVT without QT interval prolongation usually emerges in the setting of an unstable structural heart disorder, such as acute ischaemia or decompensated heart failure. Treatment is directed at the underlying heart disorder, correction of acid–base disturbances, hypoxia, and electrolyte abnormalities along with beta-blocking therapy and amiodarone. Invasive antiarrhythmic interventions, such as sympathetic denervation and transcatheter ablation, are occasionally required. Long-term treatment often includes an implantable cardioverter defibrillator. PMVT with QT interval prolongation, known as torsade de pointes VT, occurs when repolarization reserve has been exhausted by either inherited or acquired factors that prolong the QT interval. Classical features of the ‘twisting-of-the-points’ polymorphism and the short–long–short initiation sequence are common but are not universal. Treatment is directed at removal of the cause of the QT interval prolongation, correction of electrolyte disturbances (hypokalaemia and hypomagnesaemia), supplemental magnesium therapy, and treatments to shorten the QT interval such as isoproterenol, pacing, or lidocaine. Long-term treatment is focused on avoidance of QT interval prolonging factors. If the likelihood of subsequent recurrence is not low, consideration is given to placement of a permanent pacemaker or implantable cardioverter defibrillator.

Polymorphic ventricular tachycardias including torsade de pointes

ESC CardioMed ◽  
2018 ◽  
pp. 2293-2298
Author(s):  
L. Brent Mitchell
Keyword(s):  
Ventricular Tachycardia ◽  
Qt Interval ◽  
Torsade De Pointes ◽  
Term Treatment ◽  
Heart Disorder ◽  
Interval Prolongation ◽  
Cardioverter Defibrillator ◽  
Qt Interval Prolongation ◽  
Long Term Treatment

Polymorphic ventricular tachycardia (PMVT) is a rapid ventricular tachycardia in which the QRS complexes vary in coupling interval, morphology, and axis on a beat-to-beat basis. PMVT occurs in two distinct forms: PMVT without QT interval prolongation and PMVT with QT interval prolongation. The two types differ in important ways with respect to their differential diagnosis and treatment. PMVT without QT interval prolongation usually emerges in the setting of an unstable structural heart disorder, such as acute ischaemia or decompensated heart failure. Treatment is directed at the underlying heart disorder, correction of acid–base disturbances, hypoxia, and electrolyte abnormalities along with beta-blocking therapy and amiodarone. Invasive antiarrhythmic interventions, such as sympathetic denervation and transcatheter ablation, are occasionally required. Long-term treatment often includes an implantable cardioverter defibrillator. PMVT with QT interval prolongation, known as torsade de pointes PMVT, occurs when repolarization reserve has been exhausted by either inherited or acquired factors that prolong the QT interval. Classical features of the ‘twisting-of-the-points’ polymorphism and the short–long–short initiation sequence are common but are not universal. Treatment is directed at removal of the cause of the QT interval prolongation, correction of electrolyte disturbances (hypokalaemia and hypomagnesaemia), supplemental magnesium therapy, and treatments to shorten the QT interval such as isoproterenol, pacing, or lidocaine. Long-term treatment is focused on avoidance of QT interval prolonging factors. If the likelihood of subsequent recurrence is not low, consideration is given to placement of a permanent pacemaker or implantable cardioverter defibrillator.

Voriconazole-induced bradycardia without QT interval prolongation: a possible non-concentration-dependent adverse effect

2013 ◽  
Vol 39 (3) ◽  
pp. 531-532 ◽  
Author(s):  
Sébastien Perbet ◽  
Raiko Blondonnet ◽  
Renaud Guérin ◽  
Sophie Cayot-Constantin ◽  
Jean-Michel Constantin
Keyword(s):  
Adverse Effect ◽  
Qt Interval ◽  
Interval Prolongation ◽  
Qt Interval Prolongation

scholarly journals Polymorphic Ventricular Tachycardia with QT Interval Prolongation Due to a Brain Tumor

2021 ◽  
Author(s):  
Yui Nakayama ◽  
Toshiyuki Furukawa ◽  
Marika Yamada ◽  
Makoto Takano ◽  
Ikutaro Nakajima ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Brain Tumor ◽  
Qt Interval ◽  
Polymorphic Ventricular Tachycardia ◽  
Interval Prolongation ◽  
Qt Interval Prolongation

scholarly journals High Risk of QT Interval Prolongation and Torsades de Pointes Associated with Intravenous Quinidine Used for Treatment of Resistant Malaria or Babesiosis

2012 ◽  
Vol 56 (8) ◽  
pp. 4495-4499 ◽  
Author(s):  
Heather A. Wroblewski ◽  
Richard J. Kovacs ◽  
Joanna R. Kingery ◽  
Brian R. Overholser ◽  
James E. Tisdale
Keyword(s):  
Atrial Fibrillation ◽  
Adverse Effect ◽  
High Risk ◽  
Qt Interval ◽  
Cardiac Toxicity ◽  
Torsades De Pointes ◽  
Interval Prolongation ◽  
Qt Interval Prolongation

ABSTRACTCardiac toxicity may be associated with drugs used for malaria. Torsades de pointes (TdP) is a well-known adverse effect of quinidine when used for atrial fibrillation. Intravenous quinidine doses for resistant malaria are 2 to 3 times higher than those used for arrhythmias. Among 6 patients receiving quinidine for malaria or babesiosis, 4 developed QT interval prolongation and 2 experienced TdP. Clinicians should be aware that recommended doses of quinidine for malaria carry a high TdP risk.

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