scholarly journals rDEN4Δ30, a Live Attenuated Dengue Virus Type 4 Vaccine Candidate, Is Safe, Immunogenic, and Highly Infectious in Healthy Adult Volunteers

2005 ◽  
Vol 191 (5) ◽  
pp. 710-718 ◽  
Author(s):  
Anna P. Durbin ◽  
Stephen S. Whitehead ◽  
Julie McArthur ◽  
John R. Perreault ◽  
Joseph E. Blaney, Jr. ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Healthy Adult ◽  
Vaccine Candidate ◽  
Adult Volunteers

scholarly journals Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4Δ30-4995 in Healthy Adult Volunteers

2009 ◽  
Vol 81 (5) ◽  
pp. 834-841 ◽  
Author(s):  
Peter F. Wright ◽  
Anna P. Durbin ◽  
Bhavin Thumar ◽  
Brett A. McKinney ◽  
Joseph E. Blaney ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Healthy Adult ◽  
Vaccine Candidate ◽  
Phase 1 ◽  
Phase 1 Trial ◽  
Adult Volunteers

scholarly journals A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3′ Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys

2003 ◽  
Vol 77 (2) ◽  
pp. 1653-1657 ◽  
Author(s):  
Stephen S. Whitehead ◽  
Barry Falgout ◽  
Kathryn A. Hanley ◽  
Joseph E. Blaney, ◽  
Lewis Markoff ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Rhesus Monkeys ◽  
Untranslated Region ◽  
Vaccine Candidate ◽  
Homologous Region ◽  
Wild Type ◽  
Nucleotide Deletion ◽  
Intrathoracic Inoculation

ABSTRACT The Δ30 deletion mutation, which was originally created in dengue virus type 4 (DEN4) by the removal of nucleotides 172 to 143 from the 3′ untranslated region (3′ UTR), was introduced into a homologous region of wild-type (wt) dengue virus type 1 (DEN1). The resulting virus, rDEN1Δ30, was attenuated in rhesus monkeys to a level similar to that of the rDEN4Δ30 vaccine candidate. rDEN1Δ30 was more attenuated in rhesus monkeys than the previously described vaccine candidate, rDEN1mutF, which also contains mutations in the 3′ UTR, and both vaccines were highly protective against challenge with wt DEN1. Both rDEN1Δ30 and rDEN1mutF were also attenuated in HuH-7-SCID mice. However, neither rDEN1Δ30 nor rDEN1mutF showed restricted replication following intrathoracic inoculation in the mosquito Toxorhynchites splendens. The ability of the Δ30 mutation to attenuate both DEN1 and DEN4 viruses suggests that a tetravalent DEN vaccine could be generated by introduction of the Δ30 mutation into wt DEN viruses belonging to each of the four serotypes.

scholarly journals Immunogenicity of a Psoralen-Inactivated Dengue Virus Type 1 Vaccine Candidate in Mice

2009 ◽  
Vol 17 (2) ◽  
pp. 304-306 ◽  
Author(s):  
Ryan C. Maves ◽  
Roger M. Castillo Oré ◽  
Kevin R. Porter ◽  
Tadeusz J. Kochel
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Mus Musculus ◽  
Vaccine Candidate ◽  
Neutralizing Antibody

ABSTRACT We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.

Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production

2000 ◽  
Vol 111 (1) ◽  
pp. 104-111 ◽  
Author(s):  
Jeffrey A. Sosman ◽  
Amit Verma ◽  
Steven Moss ◽  
Patricia Sorokin ◽  
Michael Blend ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Interleukin 10 ◽  
Platelet Production ◽  
Adult Volunteers
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