scholarly journals A Time-Series Analysis of Clostridium difficile and Its Seasonal Association with Influenza

2010 ◽  
Vol 31 (4) ◽  
pp. 382-387 ◽  
Author(s):  
Philip M. Polgreen ◽  
Ming Yang ◽  
Lucas C. Bohnett ◽  
Joseph E. Cavanaugh

Objective.To characterize the temporal progression of the monthly incidence of Clostridium difficile infections (CDIs) and to determine whether the incidence of CDI is related to the incidence of seasonal influenza.Design.A retrospective study of patients in the Nationwide Inpatient Sample during the period from 1998 through 2005.Methods.We identified all hospitalizations with a primary or secondary diagnosis of CDI with use of International Classification of Diseases, 9th Revision, Clinical Modification codes, and we did the same for influenza. The incidence of CDI was modeled as an autoregression about a linear trend. To investigate the association of CDI with influenza, we compared national and regional CDI and influenza series data and calculated cross-correlation functions with data that had been prewhitened (filtered to remove temporal patterns common to both series). To estimate the burden of seasonal CDI, we developed a proportional measure of seasonal CDI.Results.Time-series analysis of the monthly number of CDI cases reveals a distinct positive linear trend and a clear pattern of seasonal variation (R2 = 0.98). The cross-correlation functions indicate that influenza activity precedes CDI activity on both a national and regional basis. The average burden of seasonal (ie, winter) CDI is 23%.Conclusions.The epidemiologic characteristics of CDI follow a pattern that is seasonal and associated with influenza, which is likely due to antimicrobial use during influenza seasons. Approximately 23% of average monthly CDI during the peak 3 winter months could be eliminated if CDI remained at summer levels.

Author(s):  
Victor Olsavszky ◽  
Mihnea Dosius ◽  
Cristian Vladescu ◽  
Johannes Benecke

The application of machine learning (ML) for use in generating insights and making predictions on new records continues to expand within the medical community. Despite this progress to date, the application of time series analysis has remained underexplored due to complexity of the underlying techniques. In this study, we have deployed a novel ML, called automated time series (AutoTS) machine learning, to automate data processing and the application of a multitude of models to assess which best forecasts future values. This rapid experimentation allows for and enables the selection of the most accurate model in order to perform time series predictions. By using the nation-wide ICD-10 (International Classification of Diseases, Tenth Revision) dataset of hospitalized patients of Romania, we have generated time series datasets over the period of 2008–2018 and performed highly accurate AutoTS predictions for the ten deadliest diseases. Forecast results for the years 2019 and 2020 were generated on a NUTS 2 (Nomenclature of Territorial Units for Statistics) regional level. This is the first study to our knowledge to perform time series forecasting of multiple diseases at a regional level using automated time series machine learning on a national ICD-10 dataset. The deployment of AutoTS technology can help decision makers in implementing targeted national health policies more efficiently.


2011 ◽  
Vol 3 (2) ◽  
pp. 11-15
Author(s):  
Seng Hansun

Recently, there are so many soft computing methods been used in time series analysis. One of these methods is fuzzy logic system. In this paper, we will try to implement fuzzy logic system to predict a non-stationary time series data. The data we use here is Mackey-Glass chaotic time series. We also use MATLAB software to predict the time series data, which have been divided into four groups of input-output pairs. These groups then will be used as the input variables of the fuzzy logic system. There are two scenarios been used in this paper, first is by using seven fuzzy sets, and second is by using fifteen fuzzy sets. The result shows that the fuzzy system with fifteen fuzzy sets give a better forecasting result than the fuzzy system with seven fuzzy sets. Index Terms—forecasting, fuzzy logic, Mackey-Glass chaotic, MATLAB, time series analysis


2021 ◽  
Vol 13 (3) ◽  
pp. 1187
Author(s):  
Bokyong Shin ◽  
Mikko Rask

Online deliberation research has recently developed automated indicators to assess the deliberative quality of much user-generated online data. While most previous studies have developed indicators based on content analysis and network analysis, time-series data and associated methods have been studied less thoroughly. This article contributes to the literature by proposing indicators based on a combination of network analysis and time-series analysis, arguing that it will help monitor how online deliberation evolves. Based on Habermasian deliberative criteria, we develop six throughput indicators and demonstrate their applications in the OmaStadi participatory budgeting project in Helsinki, Finland. The study results show that these indicators consist of intuitive figures and visualizations that will facilitate collective intelligence on ongoing processes and ways to solve problems promptly.


2016 ◽  
Vol 50 (1) ◽  
pp. 41-57 ◽  
Author(s):  
Linghe Huang ◽  
Qinghua Zhu ◽  
Jia Tina Du ◽  
Baozhen Lee

Purpose – Wiki is a new form of information production and organization, which has become one of the most important knowledge resources. In recent years, with the increase of users in wikis, “free rider problem” has been serious. In order to motivate editors to contribute more to a wiki system, it is important to fully understand their contribution behavior. The purpose of this paper is to explore the law of dynamic contribution behavior of editors in wikis. Design/methodology/approach – After developing a dynamic model of contribution behavior, the authors employed both the metrological and clustering methods to process the time series data. The experimental data were collected from Baidu Baike, a renowned Chinese wiki system similar to Wikipedia. Findings – There are four categories of editors: “testers,” “dropouts,” “delayers” and “stickers.” Testers, who contribute the least content and stop contributing rapidly after editing a few articles. After editing a large amount of content, dropouts stop contributing completely. Delayers are the editors who do not stop contributing during the observation time, but they may stop contributing in the near future. Stickers, who keep contributing and edit the most content, are the core editors. In addition, there are significant time-of-day and holiday effects on the number of editors’ contributions. Originality/value – By using the method of time series analysis, some new characteristics of editors and editor types were found. Compared with the former studies, this research also had a larger sample. Therefore, the results are more scientific and representative and can help managers to better optimize the wiki systems and formulate incentive strategies for editors.


2013 ◽  
Vol 10 (83) ◽  
pp. 20130048 ◽  
Author(s):  
Ben D. Fulcher ◽  
Max A. Little ◽  
Nick S. Jones

The process of collecting and organizing sets of observations represents a common theme throughout the history of science. However, despite the ubiquity of scientists measuring, recording and analysing the dynamics of different processes, an extensive organization of scientific time-series data and analysis methods has never been performed. Addressing this, annotated collections of over 35 000 real-world and model-generated time series, and over 9000 time-series analysis algorithms are analysed in this work. We introduce reduced representations of both time series, in terms of their properties measured by diverse scientific methods, and of time-series analysis methods, in terms of their behaviour on empirical time series, and use them to organize these interdisciplinary resources. This new approach to comparing across diverse scientific data and methods allows us to organize time-series datasets automatically according to their properties, retrieve alternatives to particular analysis methods developed in other scientific disciplines and automate the selection of useful methods for time-series classification and regression tasks. The broad scientific utility of these tools is demonstrated on datasets of electroencephalograms, self-affine time series, heartbeat intervals, speech signals and others, in each case contributing novel analysis techniques to the existing literature. Highly comparative techniques that compare across an interdisciplinary literature can thus be used to guide more focused research in time-series analysis for applications across the scientific disciplines.


Author(s):  
Seng Hansun ◽  
Subanar Subanar

      Abstract— Recently, many soft computing methods have been used and implemented in time series analysis. One of the methods is fuzzy hybrid model which has been designed and developed to improve the accuracy of time series prediction.      Popoola has developed a fuzzy hybrid model which using wavelet transformation as a pre-processing tool, and commonly known as fuzzy-wavelet method. In this thesis, a new approach of fuzzy-wavelet method has been introduced. If in Popoola’s fuzzy-wavelet, a fuzzy inference system is built for each decomposition data, then on the new approach only two fuzzy inference systems will be needed. By that way, the computation needed in time series analysis can be pressed.      The research is continued by making new software that can be used to analyze any given time series data based on the forecasting method applied. As a comparison there are three forecasting methods implemented on the software, i.e. fuzzy conventional method, Popoola’s fuzzy-wavelet, and the new approach of fuzzy-wavelet method. The software can be used in short-term forecasting (single-step forecast) and long-term forecasting. There are some limitation to the software, i.e. maximum data can be predicted is 300, maximum interval can be built is 7, and maximum transformation level can be used is 10. Furthermore, the accuracy and robustness of the proposed method will be compared to the other forecasting methods, so that can give us a brief description about the accuracy and robustness of the proposed method. Keywords—  fuzzy, wavelet, time series, soft computing


2021 ◽  
Author(s):  
Dayana Benny

BACKGROUND Turin, a province in the Piedmont region sees second highest new COVID-19 infections in Northern part of Italy as of March 31, 2021. During the first wave of pandemic, many restrictive measures were introduced in this province. There are many studies that conducted time series analysis of various regions in Italy, but studies that are analysing the data in province level are limited. Also, no applications of Cross Correlation Function(CCF) have been proposed to analyse relationships between COVID-19 new cases and community mobility at the provincial level in Italy. OBJECTIVE The goal of this time series analysis is to find how the restrictive measures in Turin province, Italy impacted community mobility and helped in flattening the epidemic curve during the first wave of the pandemic. METHODS A simple time series analysis is conducted in this study to analyse whether there is an association between COVID-19 daily cases and community mobility. In this study, we analysed whether the time series of the parameter that estimates the reproduction of infection in the outbreak is related to the past lags of community mobility time series by performing cross-correlation analysis. RESULTS Multiple regression is carried out in which the R0 variable is a linear function of past lags 6, 7, 8, and 1 of the community mobility variable and all coefficients are statistically significant where P = 0.024043, 2.69e-05, 0.045350 and 0.000117 respectively. The cross-correlation between data fitted from the significant past lags of community mobility and transformed basic reproduction number (R0) time-series is obtained in such a manner that the R0 of a day is related to the past lags of community mobility in Turin province. CONCLUSIONS Our analysis shows that the restrictive measures are having an impact on community mobility during the first wave of COVID-19 and it can be related to the reported secondary cases of COVID-19 in Turin province at that time. Through further improvement, this simple model could serve as preliminary research for developing right preventive methods during the early stages of an epidemic.


2021 ◽  
Author(s):  
Dayana Benny

BACKGROUND Turin, a province in the Piedmont region sees second highest new COVID-19 infections in Northern part of Italy as of March 31, 2021. During the first wave of pandemic, many restrictive measures were introduced in this province. There are many studies that conducted time series analysis of various regions in Italy, but studies that are analysing the data in province level are limited. Also, no applications of Cross Correlation Function(CCF) have been proposed to analyse relationships between COVID-19 new cases and community mobility at the provincial level in Italy. OBJECTIVE The goal of this time series analysis is to find how the restrictive measures in Turin province, Italy impacted community mobility and helped in flattening the epidemic curve during the first wave of the pandemic. METHODS A simple time series analysis is conducted in this study to analyse whether there is an association between COVID-19 daily cases and community mobility. In this study, we analysed whether the time series of the parameter that estimates the reproduction of infection in the outbreak is related to the past lags of community mobility time series by performing cross-correlation analysis. RESULTS Multiple regression is carried out in which the R0 variable is a linear function of past lags 6, 7, 8, and 1 of the community mobility variable and all coefficients are statistically significant where P = 0.024043, 2.69e-05, 0.045350 and 0.000117 respectively. The cross-correlation between data fitted from the significant past lags of community mobility and transformed basic reproduction number (R0) time-series is obtained in such a manner that the R0 of a day is related to the past lags of community mobility in Turin province. CONCLUSIONS Our analysis shows that the restrictive measures are having an impact on community mobility during the first wave of COVID-19 and it can be related to the reported secondary cases of COVID-19 in Turin province at that time. Through further improvement, this simple model could serve as preliminary research for developing right preventive methods during the early stages of an epidemic.


2008 ◽  
Vol 88 (9) ◽  
pp. 1022-1033 ◽  
Author(s):  
Shohei Ohgi ◽  
Satoru Morita ◽  
Kek Khee Loo ◽  
Chihiro Mizuike

Background and Purpose Comparisons of spontaneous movements of premature infants with brain injuries and those without brain injuries can provide insights into normal and abnormal processes in the ontogeny of motor development. In this study, the characteristics of spontaneous upper-extremity movements of premature infants with brain injuries and those without brain injuries were examined with time series analysis. Subjects Participants were 7 premature infants with brain injuries and 7 matched, low-risk, premature infants at the age of 1 month after term. Methods A triaxial accelerometer was used to measure upper-extremity limb acceleration in 3-dimensional space. Acceleration signals were recorded from the right wrist when the infant was in an active, alert state and lying in the supine position. The recording time was 200 seconds. The acceleration signal was sampled at a rate of 200 Hz. The acceleration time series data were analyzed by nonlinear analysis as well as linear analysis. Results The nonlinear time series analysis indicated that spontaneous movements of premature infants have nonlinear, chaotic, dynamic characteristics. The movements of the infants with brain injuries were characterized by larger dimensionality, and they were more unstable and unpredictable than those of infants without brain injuries. Discussion and Conclusion As determined by nonlinear analysis, the spontaneous movements of the premature infants with brain injuries had the characteristics of increased disorganization compared with those of the infants without brain injuries. Infants with brain injuries may manifest problems with self-organization as a function of the coordination of subsystems. Physical therapists should be able to support interactions among the subsystems and promote self-organization of motor learning through the individualized provision of various sensorimotor experiences for infants.


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