Mark Dennis Robinson. The Market in Mind: How Financialization Is Shaping Neuroscience, Translational Medicine, and Innovation in Biotechnology. xi + 309 pp., notes, bibl., index. Cambridge, Mass./London: MIT Press, 2019. $40 (paper); ISBN 9780262536875.

Isis ◽  
2021 ◽  
Vol 112 (1) ◽  
pp. 213-214
Author(s):  
Lianne Habinek
Keyword(s):  
Translational Medicine

Translational medicine

2011 ◽  
Vol 152 (47) ◽  
pp. 1894-1902
Author(s):  
János Antal ◽  
Attila Timár
Keyword(s):  
Pharmaceutical Industry ◽  
Research And Development ◽  
Patient Care ◽  
Computer Modeling ◽  
Translational Medicine ◽  
Scientific Discipline ◽  
Laboratory Research ◽  
Basic Sciences ◽  
Industry Research ◽  
Underlying Basis

Translational medicine is the emerging scientific discipline of the last decade which will set the benchmark for the pharmaceutical industry research and development, integrates inputs from the basic sciences of computer modeling and laboratory research through the pre-clinical and clinical phases of human research to the assimilation of new therapies and treatments into everyday practice of patient care and prevention. With this brief insight authors tried in their humble way to summarize the underlying basis, the present and the potential future of this emerging view, to draw attention to some of the challenges and tasks it faces and to highlight some of the promising approaches, trends and model developments and applications. Orv. Hetil., 2011, 152, 1894–1902.

Exosome: An Emerging Source of Biomarkers for Human Diseases

2019 ◽  
Vol 19 (6) ◽  
pp. 387-394 ◽  
Author(s):  
Li Xu ◽  
Long-Fei Wu ◽  
Fei-Yan Deng
Keyword(s):  
Breast Milk ◽  
Intercellular Communication ◽  
Translational Medicine ◽  
Disease Diagnosis ◽  
Human Diseases ◽  
Isolation And Identification ◽  
Biomarker Identification ◽  
Biological Features ◽  
Diagnosis And Prognosis ◽  
Novel Biomarkers

Exosomes are 30-120nm long endocytic membrane-derived vesicles, which are secreted by various types of cells and stably present in body fluids, such as plasma, urine, saliva and breast milk. Exosomes participate in intercellular communication. Recently accumulative studies have suggested that exosomes may serve as novel biomarkers for disease diagnosis and prognosis. Herein, we reviewed the biological features of exosomes, technologies for exosome isolation and identification, as well as progress in exosomal biomarker identification, highlighting the relevance of exosome to human diseases and significance and great potential in translational medicine.

scholarly journals A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 480
Author(s):  
Caitlyn A. Moore ◽  
Zain Siddiqui ◽  
Griffin J. Carney ◽  
Yahaira Naaldijk ◽  
Khadidiatou Guiro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Translational Medicine ◽  
Drug Response ◽  
Drug Approval ◽  
3D Models ◽  
3D Bioprinting ◽  
Effective Evaluation ◽  
Experimental Systems ◽  
Cancer Models

Translational medicine requires facile experimental systems to replicate the dynamic biological systems of diseases. Drug approval continues to lag, partly due to incongruencies in the research pipeline that traditionally involve 2D models, which could be improved with 3D models. The bone marrow (BM) poses challenges to harvest as an intact organ, making it difficult to study disease processes such as breast cancer (BC) survival in BM, and to effective evaluation of drug response in BM. Furthermore, it is a challenge to develop 3D BM structures due to its weak physical properties, and complex hierarchical structure and cellular landscape. To address this, we leveraged 3D bioprinting to create a BM structure with varied methylcellulose (M): alginate (A) ratios. We selected hydrogels containing 4% (w/v) M and 2% (w/v) A, which recapitulates rheological and ultrastructural features of the BM while maintaining stability in culture. This hydrogel sustained the culture of two key primary BM microenvironmental cells found at the perivascular region, mesenchymal stem cells and endothelial cells. More importantly, the scaffold showed evidence of cell autonomous dedifferentiation of BC cells to cancer stem cell properties. This scaffold could be the platform to create BM models for various diseases and also for drug screening.

scholarly journals Systems and Clinical Pharmacology of COVID-19 Therapeutic Candidates: A Clinical and Translational Medicine Perspective

2020 ◽  
Author(s):  
Simone Perazzolo ◽  
Linxi Zhu ◽  
Weixian Lin ◽  
Alexander Nguyen ◽  
Rodney J.Y. Ho
Keyword(s):  
Clinical Pharmacology ◽  
Translational Medicine

scholarly journals Continued improvement of translational medicine – A cohesive approach

2021 ◽  
Vol 29 ◽  
pp. A1-A2
Author(s):  
Chelsea Hopkins ◽  
Ling Qin
Keyword(s):  
Translational Medicine

Identification and Elucidation of the Biology of Adverse Events: The Challenges of Safety Assessment and Translational Medicine

2011 ◽  
Vol 17 (21) ◽  
pp. 6641-6645 ◽  
Author(s):  
Kenneth W. Turteltaub ◽  
Myrtle A. Davis ◽  
Leigh Ann Burns-Naas ◽  
Michael P. Lawton ◽  
Adam M. Clark ◽  
...  
Keyword(s):  
Adverse Events ◽  
Translational Medicine ◽  
Safety Assessment
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