Translational Medicine: New Power in Modern Medical Development

Translational medicine is the emerging scientific discipline of the last decade which will set the benchmark for the pharmaceutical industry research and development, integrates inputs from the basic sciences of computer modeling and laboratory research through the pre-clinical and clinical phases of human research to the assimilation of new therapies and treatments into everyday practice of patient care and prevention. With this brief insight authors tried in their humble way to summarize the underlying basis, the present and the potential future of this emerging view, to draw attention to some of the challenges and tasks it faces and to highlight some of the promising approaches, trends and model developments and applications. Orv. Hetil., 2011, 152, 1894–1902.

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Advances in Translational Medicine Research

10.36959/457 ◽

2020 ◽

Keyword(s):

Translational Medicine ◽

Medicine Research ◽

Translational Medicine Research

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How Translational Medicine Is Progressively Redefining Healthcare: From Bench to Bedside, the Patient Is the Bedrock of Translational Research

SSRN Electronic Journal ◽

10.2139/ssrn.3090737 ◽

2017 ◽

Author(s):

Fritz Dufour

Keyword(s):

Translational Research ◽

Translational Medicine

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Exosome: An Emerging Source of Biomarkers for Human Diseases

Current Molecular Medicine ◽

10.2174/1566524019666190429144310 ◽

2019 ◽

Vol 19 (6) ◽

pp. 387-394 ◽

Cited By ~ 4

Author(s):

Li Xu ◽

Long-Fei Wu ◽

Fei-Yan Deng

Keyword(s):

Breast Milk ◽

Intercellular Communication ◽

Translational Medicine ◽

Disease Diagnosis ◽

Human Diseases ◽

Isolation And Identification ◽

Biomarker Identification ◽

Biological Features ◽

Diagnosis And Prognosis ◽

Novel Biomarkers

Exosomes are 30-120nm long endocytic membrane-derived vesicles, which are secreted by various types of cells and stably present in body fluids, such as plasma, urine, saliva and breast milk. Exosomes participate in intercellular communication. Recently accumulative studies have suggested that exosomes may serve as novel biomarkers for disease diagnosis and prognosis. Herein, we reviewed the biological features of exosomes, technologies for exosome isolation and identification, as well as progress in exosomal biomarker identification, highlighting the relevance of exosome to human diseases and significance and great potential in translational medicine.

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A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models

Polymers ◽

10.3390/polym13040480 ◽

2021 ◽

Vol 13 (4) ◽

pp. 480

Author(s):

Caitlyn A. Moore ◽

Zain Siddiqui ◽

Griffin J. Carney ◽

Yahaira Naaldijk ◽

Khadidiatou Guiro ◽

...

Keyword(s):

Breast Cancer ◽

Bone Marrow ◽

Translational Medicine ◽

Drug Response ◽

Drug Approval ◽

3D Models ◽

3D Bioprinting ◽

Effective Evaluation ◽

Experimental Systems ◽

Cancer Models

Translational medicine requires facile experimental systems to replicate the dynamic biological systems of diseases. Drug approval continues to lag, partly due to incongruencies in the research pipeline that traditionally involve 2D models, which could be improved with 3D models. The bone marrow (BM) poses challenges to harvest as an intact organ, making it difficult to study disease processes such as breast cancer (BC) survival in BM, and to effective evaluation of drug response in BM. Furthermore, it is a challenge to develop 3D BM structures due to its weak physical properties, and complex hierarchical structure and cellular landscape. To address this, we leveraged 3D bioprinting to create a BM structure with varied methylcellulose (M): alginate (A) ratios. We selected hydrogels containing 4% (w/v) M and 2% (w/v) A, which recapitulates rheological and ultrastructural features of the BM while maintaining stability in culture. This hydrogel sustained the culture of two key primary BM microenvironmental cells found at the perivascular region, mesenchymal stem cells and endothelial cells. More importantly, the scaffold showed evidence of cell autonomous dedifferentiation of BC cells to cancer stem cell properties. This scaffold could be the platform to create BM models for various diseases and also for drug screening.

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