The Role of the Injured Surface in the Production of the Injury Potential of Frog Muscle

1941 ◽  
Vol 14 (1) ◽  
pp. 78-83 ◽  
Author(s):  
H. Burr Steinbach
Keyword(s):  
Frog Muscle ◽  
Injury Potential

LOW-DOSE VASOPRESSIN ATTENUATES CARDIOPULMONARY DYSFUNCTION IN SHEEP WITH COMBINED BURN AND SMOKE INHALATION INJURY: POTENTIAL ROLE OF 3-NITROTYROSINE.

2005 ◽  
Vol 33 ◽  
pp. A15
Author(s):  
Martin Westphal ◽  
Marc O Maybauer ◽  
Dirk M Maybauer ◽  
Perenlei Enkhbaatar ◽  
Beena B Westphal-Varghese ◽  
...  
Keyword(s):  
Low Dose ◽  
Potential Role ◽  
Inhalation Injury ◽  
Smoke Inhalation ◽  
Smoke Inhalation Injury ◽  
Injury Potential

Tissue lipopolysaccharide-binding protein expression in rats after thermal injury: potential role of TNF-α

Burns ◽  
2004 ◽  
Vol 30 (3) ◽  
pp. 225-231 ◽  
Author(s):  
Catherine W.H Fang ◽  
Yong-Ming Yao ◽  
Hong-Xia Zhai ◽  
Yan Yu ◽  
Ye Wu ◽  
...  
Keyword(s):  
Protein Expression ◽  
Thermal Injury ◽  
Potential Role ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Tnf Α ◽  
Lipopolysaccharide Binding ◽  
Injury Potential

scholarly journals Macrophage polarization in chronic kidney disease: a balancing act between renal recovery and decline?

2019 ◽  
Vol 317 (6) ◽  
pp. F1409-F1413 ◽  
Author(s):  
Jason E. Engel ◽  
Alejandro R. Chade
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Injury ◽  
Dynamic Balance ◽  
Macrophage Polarization ◽  
M1 Phenotype ◽  
Anti Inflammatory ◽  
And Function ◽  
Injury Potential

Macrophages are heterogenous cells of the innate immune system that can fluidly modulate their phenotype to respond to their local microenvironment. They are found throughout the renal compartments, where they contribute to homeostasis and function. However, renal injury activates molecular pathways that initially stimulate differentiation of macrophages into a proinflammatory M1 phenotype. Later in the course of healing, abundant apoptotic debris and anti-inflammatory cytokines induce the production of anti-inflammatory M2 macrophages, which contribute to tissue regeneration and repair. Thus, the dynamic balance of M1 and M2 populations may outline the burden of inflammation and process of tissue repair that define renal outcomes, which has been the impetus for therapeutic efforts targeting macrophages. This review will discuss the role of these phenotypes in the progression of chronic renal injury, potential pathogenic mechanisms, and the promise of macrophage-based therapeutic applications for chronic kidney disease.

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