Monte Carlo simulations of the relative biological effectiveness for DNA double strand breaks from 300 MeV u−1carbon-ion beams

2015 ◽  
Vol 60 (15) ◽  
pp. 5995-6012 ◽  
Author(s):  
Y W Huang ◽  
C Y Pan ◽  
Y Y Hsiao ◽  
T C Chao ◽  
C C Lee ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Relative Biological Effectiveness ◽  
Ion Beams ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Biological Effectiveness

scholarly journals Calculated relative biological effectiveness (RBE) for initial DNA double-strand breaks (DSB) from flattening filter and flattening filter-free 6 MV X-ray fields

BJR|Open ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 20200072
Author(s):  
Hisashi Nakano ◽  
Daisuke Kawahara ◽  
Satoshi Tanabe ◽  
Satoru Utsunomiya ◽  
Takeshi Takizawa ◽  
...  
Keyword(s):  
Relative Biological Effectiveness ◽  
Double Strand Breaks ◽  
Central Axis ◽  
X Rays ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Depth Measurement ◽  
Dna Dsbs ◽  
Flattening Filter ◽  
Biological Effectiveness

Objectives: We evaluated the radiobiological effectiveness based on the yields of DNA double-strand breaks (DSBs) of field induction with flattening filter (FF) and FF-free (FFF) photon beams. Methods: We used the particle and heavy ion transport system (PHITS) and a water equivalent phantom (30 × 30 × 30 cm3) to calculate the physical qualities of the dose-mean lineal energy (yD) with 6 MV FF and FFF. The relative biological effectiveness based on the yields of DNA-DSBs (RBEDSB) was calculated for standard radiation such as 220 kVp X-rays by using the estimating yields of SSBs and DSBs. The measurement points used to calculate the in-field yD and RBEDSB were located at a depth of 3, 5, and 10 cm in the water equivalent phantom on the central axis. Measurement points at 6, 8, and 10 cm in the lateral direction of each of the three depths from the central axis were set to calculate the out-of-field yD and RBEDSB. Results: The RBEDSB of FFF in-field was 1.7% higher than FF at each measurement depth. The RBEDSB of FFF out-of-field was 1.9 to 6.4% higher than FF at each depth measurement point. As the distance to out-of-field increased, the RBEDSB of FFF rose higher than those of FF. FFF has a larger RBEDSB than FF based on the yields of DNA-DSBs as the distance to out-of-field increased. Conclusions: The out-of-field radiobiological effect of FFF could thus be greater than that of FF since the spreading of the radiation dose out-of-field with FFF could be a concern compared to the FF. Advances in knowledge: The RBEDSB of FFF of out-of-field might be larger than FF.

scholarly journals Clinically relevant nanodosimetric simulation of DNA damage complexity from photons and protons

RSC Advances ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 6845-6858 ◽  
Author(s):  
N. T. Henthorn ◽  
J. W. Warmenhoven ◽  
M. Sotiropoulos ◽  
A. H. Aitkenhead ◽  
E. A. K. Smith ◽  
...  
Keyword(s):  
Dna Damage ◽  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Proton Therapy ◽  
Relative Biological Effectiveness ◽  
Biological Effectiveness ◽  
Mechanistic Understanding

Relative Biological Effectiveness (RBE) is a controversial and important topic in proton therapy. This work uses Monte Carlo simulations of DNA damage for protons and photons to probe this phenomenon, providing a plausible mechanistic understanding.

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