scholarly journals Label-free detection of single nanoparticles with disordered nanoisland surface plasmon sensor

2021 ◽  
Author(s):  
Hongki Lee ◽  
Joel Berk ◽  
Aaron Webster ◽  
Donghyun Kim ◽  
Matthew R Foreman
Keyword(s):  
Surface Plasmon ◽  
Experimental Measurements ◽  
Label Free ◽  
Sensor Surface ◽  
Supporting Surface ◽  
Bright Field ◽  
Label Free Detection ◽  
Speckle Patterns ◽  
Leakage Radiation ◽  
Plasmon Polaritons

Abstract We report sensing of single nanoparticles using disordered metallic nanoisland substrates supporting surface plasmon polaritons (SPPs). Speckle patterns arising from leakage radiation of elastically scattered SPPs provides a unique fingerprint of the scattering microstructure at the sensor surface. Experimental measurements of the speckle decorrelation are presented and shown to enable detection of sorption of individual gold nanoparticles and polystyrene beads. Our approach is verified through bright-field and fluorescence imaging of particles adhering to the nanoisland substrate.

scholarly journals A sandwich-like strategy for the label-free detection of oligonucleotides by surface plasmon fluorescence spectroscopy (SPFS)

The Analyst ◽  
2016 ◽  
Vol 141 (20) ◽  
pp. 5784-5791 ◽  
Author(s):  
Qiang Su ◽  
Gilbert Nöll
Keyword(s):  
Fluorescence Spectroscopy ◽  
Surface Plasmon ◽  
Molecular Beacons ◽  
Label Free ◽  
Background Fluorescence ◽  
Detection Strategy ◽  
Cutting Surface ◽  
Label Free Detection ◽  
Lower Background

Cutting surface-bound optical molecular beacons results in a sandwich-like detection strategy with lower background fluorescence.

scholarly journals Trends in SPR Cytometry: Advances in Label-Free Detection of Cell Parameters

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 102 ◽  
Author(s):  
Richard Schasfoort ◽  
Fikri Abali ◽  
Ivan Stojanovic ◽  
Gestur Vidarsson ◽  
Leon Terstappen
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Mammalian Cells ◽  
Living Cells ◽  
Label Free ◽  
Intact Cells ◽  
Cell Parameters ◽  
Spr Imaging ◽  
Label Free Detection

SPR cytometry entails the measurement of parameters from intact cells using the surface plasmon resonance (SPR) phenomenon. Specific real-time and label-free binding of living cells to sensor surfaces has been made possible through the availability of SPR imaging (SPRi) instruments and researchers have started to explore its potential in the last decade. Here we will discuss the mechanisms of detection and additionally describe the problems and issues of mammalian cells in SPR biosensing, both from our own experience and with information from the literature. Finally, we build on the knowledge and applications that has already materialized in this field to give a forecast of some exciting applications for SPRi cytometry.

Label-Free Detection of Nappa: Surface Plasmon Resonance

2019 ◽  
pp. 287-304
Author(s):  
Manuel Fuentes ◽  
Sanjeeva Svrivastava ◽  
Nirosahan Ramachandran ◽  
Eugenie Hainsworth ◽  
Josh LaBaer
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Label Free ◽  
Label Free Detection

scholarly journals Surface Plasmon Resonance Biosensor for Rapid Label-Free Detection of Microribonucleic Acid at Subfemtomole Level

2010 ◽  
Vol 82 (24) ◽  
pp. 10110-10115 ◽  
Author(s):  
Hana Šípová ◽  
Shile Zhang ◽  
Aimée M. Dudley ◽  
David Galas ◽  
Kai Wang ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Label Free ◽  
Surface Plasmon Resonance Biosensor ◽  
Label Free Detection
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