The role of idiotypic interactions in the adaptive immune system: a belief-propagation approach

The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the adipocyte as an endocrine and immunologic cell has been progressively established. Like the macrophage, the adipocyte is capable of linking the innate and adaptive immune system through the secretion of adipokines and cytokines; exosome release of lipids, hormones, and microRNAs; and contact interaction with other immune cells. Key innate immune cells in AT include adipocytes, macrophages, neutrophils, and innate lymphoid cells type 2 (ILC2s). The role of the innate immune system in promoting adipose tissue inflammation in obesity will be highlighted in this review. T cells and B cells also play important roles in contributing to AT inflammation and are discussed in this series in the chapter on adaptive immunity.

Download Full-text

Effects of vitamin D on the peripheral adaptive immune system: A review

Autoimmunity Reviews ◽

10.1016/j.autrev.2011.05.002 ◽

2011 ◽

Vol 10 (12) ◽

pp. 733-743 ◽

Cited By ~ 148

Author(s):

Evelyn Peelen ◽

Stephanie Knippenberg ◽

Anne-Hilde Muris ◽

Mariëlle Thewissen ◽

Joost Smolders ◽

...

Keyword(s):

Vitamin D ◽

Immune System ◽

Adaptive Immune System ◽

Adaptive Immune ◽

System A

Download Full-text

Role of immune cells in the ocular manifestations of pemphigoid diseases

Therapeutic Advances in Ophthalmology ◽

10.1177/2515841419868128 ◽

2019 ◽

Vol 11 ◽

pp. 251584141986812

Author(s):

Tanima Bose

Keyword(s):

Immune System ◽

Immune Cells ◽

Γδ T Cells ◽

Adaptive Immune System ◽

Mucous Membrane Pemphigoid ◽

Adaptive Immune ◽

Ocular Manifestations ◽

Different Types ◽

Ocular Distribution

Pemphigoid disease is classified according to the phenotypical location of the disease and the presence of different types of antibodies. The ocular distribution of pemphigoid mainly occurs in patients with bullous pemphigoid and mucous membrane pemphigoid. Several immune cells, including the cells of the innate immune system (neutrophils and γδ T cells) and the adaptive immune system (T and B cells), are involved in pemphigoid disease. The treatment of pemphigoid is still wide-ranging, and the most utilized treatment is the use of immunosuppressants and corticosteroids. In this scenario, it is absolutely important to screen the immune cells that are involved in this group of diseases and to determine if a targeted treatment approach is plausible. In conclusion, this review will identify some newer treatment possibilities for the whole spectrum of pemphigoid diseases.

Download Full-text

Role of the adaptive immune system in hypertension

Current Opinion in Pharmacology ◽

10.1016/j.coph.2010.01.006 ◽

2010 ◽

Vol 10 (2) ◽

pp. 203-207 ◽

Cited By ~ 108

Author(s):

David G Harrison ◽

Antony Vinh ◽

Heinrich Lob ◽

Meena S Madhur

Keyword(s):

Immune System ◽

Adaptive Immune System ◽

Adaptive Immune

Download Full-text

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Journal of Diabetes Research ◽

10.1155/2017/6494795 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 52

Author(s):

Chang Xia ◽

Xiaoquan Rao ◽

Jixin Zhong

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

T Cells ◽

Immune System ◽

Critical Role ◽

Adaptive Immune System ◽

Metabolic Inflammation ◽

Adaptive Immune

Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.

Download Full-text