Dual energy x-ray absorptiometry for diagnosis of bone mineral density in pre and post – menopausal women.

Bone mineral densitometry was done in 107 women in their post-menopausal period using Dualenergy X-ray absorptiometry method. All the patients were presented with low back pain.Quantification of bone mineral density was done in proximal femur and lumber spines of all thepatients. Sixty-eight patients showed normal bone mineral density in our study. Rest 39 patientsshowed declination of bone mineral density from mild osteopenia to severe osteoporosis. Weconclude that Dual energy X-ray absorptiometry bone mineral measurement is an unique, noninvasivemethod of detecting bone mass disorder in post-menopausal women with low backpain and should be the first choice of investigation.doi: 10.3329/taj.v15i2.3909TAJ December 2002; Vol.15(2):64-67

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Effect of single dose intravenous zoledronic acid on bone mineral density in post-menopausal osteoporosis of Bangladeshi women

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v36i3.7285 ◽

1970 ◽

Vol 36 (3) ◽

pp. 74-77

Author(s):

M Hossain ◽

IH Chowdhury ◽

MA Emran ◽

AHMA Habib ◽

AKM Asaduzzaman ◽

...

Keyword(s):

Bone Mineral Density ◽

Zoledronic Acid ◽

Dual Energy ◽

Mineral Density ◽

X Ray ◽

T Score ◽

Post Menopausal Osteoporosis ◽

Menopausal Women ◽

Post Menopausal ◽

Menopausal Osteoporosis

The osteoporosis is a major health threat that affects every third post-menopausal women. Postmenopausal osteoporosis is complicated with vertebral, femoral or radius fracture. This prospective study on post-menopausal osteoporosis was carried out in the Pain Centre, Department of Anaesthesia, Analgesia and Intensive Care Medicine of BSMMU, Dhaka during the period of January 2008 to January 2010. The post-menopausal women with back pain were screened by spinal radiographs and dual-energy X-ray absorptiometry (DXA) of lumbar spine to determine the bone mineral density (BMD). The woman after menopause with a BMD T-score of -2.5 or less with or without evidence of vertebral fracture is considered as post-menopausal osteoporosis. A total of 55 post-menopausal osteoporotic patients were assigned to receive a single dose of IV infusion of zoledronic acid (5mg) along with dietary calcium and vitamin-D. The spinal radiographs and dual-energy X-ray absorptiometry (DXA) were repeated in all the 55 patients at 12 months following zoledronic acid infusion. The mean BMD of lumbar spine increased significantly from pre-infusion value of 0.75695g/cm2 to post-infusion of 0.80216 g/cm2. The T-score also increased from pre infusion value of -3.567±0.77 to -3.158±0.08 in 12 months following the infusion (P<0.01). The increase is 5.026% higher than pre infusion values. The spinal radiographs taken before infusion of zoledronic acid, showed 14 fractures. There was no new fracture in any case during the 12 months study period. So, it can be concluded that once yearly IV infusion of zoledronic acid is associated with a significant increase in BMD and decrease in the risk of vertebral fracture. DOI: 10.3329/bmrcb.v36i3.7285Bangladesh Med Res Counc Bull 2010; 36: 74 -77

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Bone health index by hand X-ray compared with bone mineral density by dual-energy X-ray absorptiometry in children with Duchenne muscular dystrophy

Bone Abstracts ◽

10.1530/boneabs.7.p91 ◽

2019 ◽

Author(s):

Jonathan J Bowden ◽

Ramkumar Krishnamurthy ◽

Houchun Hu ◽

Brent Adler ◽

Rajesh Krishnamurthy ◽

...

Keyword(s):

Bone Mineral Density ◽

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Bone Mineral ◽

Bone Health ◽

Dual Energy ◽

Health Index ◽

Mineral Density ◽

X Ray ◽

Bone Health Index

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Bio-impedance and quantitative ultrasound to measure bone mineral density in post-menopausal women from a rural Mexican community

Bone Abstracts ◽

10.1530/boneabs.5.p300 ◽

2016 ◽

Author(s):

Fernando Blanco-Rodriguez ◽

Nicole Ellis-Infante ◽

Victor Lopez-Rivas ◽

Sherlin May-Kim ◽

Charlotte Pickett ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Quantitative Ultrasound ◽

Mineral Density ◽

Menopausal Women ◽

Mexican Community ◽

Post Menopausal ◽

Measure Bone Mineral Density

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POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3819 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 227.2-228

Author(s):

D. Claire ◽

M. Geoffroy ◽

L. Kanagaratnam ◽

C. Isabelle ◽

A. Hittinger ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

General Population ◽

Bone Mineral ◽

Bone Densitometry ◽

Dual Energy ◽

Mineral Density ◽

Least Significant Change ◽

X Ray ◽

Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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