scholarly journals Effect of single dose intravenous zoledronic acid on bone mineral density in post-menopausal osteoporosis of Bangladeshi women

1970 ◽  
Vol 36 (3) ◽  
pp. 74-77
Author(s):  
M Hossain ◽  
IH Chowdhury ◽  
MA Emran ◽  
AHMA Habib ◽  
AKM Asaduzzaman ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Zoledronic Acid ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
T Score ◽  
Post Menopausal Osteoporosis ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

The osteoporosis is a major health threat that affects every third post-menopausal women. Postmenopausal osteoporosis is complicated with vertebral, femoral or radius fracture. This prospective study on post-menopausal osteoporosis was carried out in the Pain Centre, Department of Anaesthesia, Analgesia and Intensive Care Medicine of BSMMU, Dhaka during the period of January 2008 to January 2010. The post-menopausal women with back pain were screened by spinal radiographs and dual-energy X-ray absorptiometry (DXA) of lumbar spine to determine the bone mineral density (BMD). The woman after menopause with a BMD T-score of -2.5 or less with or without evidence of vertebral fracture is considered as post-menopausal osteoporosis. A total of 55 post-menopausal osteoporotic patients were assigned to receive a single dose of IV infusion of zoledronic acid (5mg) along with dietary calcium and vitamin-D. The spinal radiographs and dual-energy X-ray absorptiometry (DXA) were repeated in all the 55 patients at 12 months following zoledronic acid infusion. The mean BMD of lumbar spine increased significantly from pre-infusion value of 0.75695g/cm2 to post-infusion of 0.80216 g/cm2. The T-score also increased from pre infusion value of -3.567±0.77 to -3.158±0.08 in 12 months following the infusion (P<0.01). The increase is 5.026% higher than pre infusion values. The spinal radiographs taken before infusion of zoledronic acid, showed 14 fractures. There was no new fracture in any case during the 12 months study period. So, it can be concluded that once yearly IV infusion of zoledronic acid is associated with a significant increase in BMD and decrease in the risk of vertebral fracture. DOI: 10.3329/bmrcb.v36i3.7285Bangladesh Med Res Counc Bull 2010; 36: 74 -77

Diagnosis of Osteoporosis using modified U-net architecture with attention unit in DEXA and X-ray images

2020 ◽  
Vol 28 (5) ◽  
pp. 953-973 ◽  
Author(s):  
S.M. Nazia Fathima ◽  
R. Tamilselvi ◽  
M. Parisa Beham ◽  
D. Sabarinathan
Keyword(s):  
Bone Mineral Density ◽  
Classification Accuracy ◽  
Standard Technique ◽  
Dual Energy ◽  
Mineral Density ◽  
Medical Field ◽  
Current Standard ◽  
Diagnosis Of Osteoporosis ◽  
X Ray ◽  
T Score

BACKGROUND: Osteoporosis, a silent killing disease of fracture risk, is normally determined based on the bone mineral density (BMD) and T-score values measured in bone. However, development of standard algorithms for accurate segmentation and BMD measurement from X-ray images is a challenge in the medical field. OBJECTIVE: The purpose of this work is to more accurately measure BMD from X-ray images, which can overcome the limitations of the current standard technique to measure BMD using Dual Energy X-ray Absorptiometry (DEXA) such as non-availability and inaccessibility of DEXA machines in developing countries. In addition, this work also attempts to analyze the DEXA scan images for better segmentation and measurement of BMD. METHODS: This work employs a modified U-Net with Attention unit for accurate segmentation of bone region from X-Ray and DEXA images. A linear regression model is developed to compute BMD and T-score. Based on the value of T-score, the images are then classified as normal, osteopenia or osteoporosis. RESULTS: The proposed network is experimented with the two internally collected datasets namely, DEXSIT and XSITRAY, comprised of DEXA and X-ray images, respectively. The proposed method achieved an accuracy of 88% on both datasets. The Dice score on DEXSIT and XSITRAY is 0.94 and 0.92, respectively. CONCLUSION: Our modified U-Net with attention unit achieves significantly higher results in terms of Dice score and classification accuracy. The computed BMD and T-score values of the proposed method are also compared with the respective clinical reports for validation. Hence, using the digitized X-Ray images can be used to detect osteoporosis efficiently and accurately.

scholarly journals Relationship between body mass index and osteoporosis

2016 ◽  
Vol 69 (suppl. 1) ◽  
pp. 85-88
Author(s):  
Radmila Matijevic ◽  
Vladimir Harhaji ◽  
Srdjan Ninkovic ◽  
Zoran Gojkovic ◽  
Predrag Rasovic ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Body Mass ◽  
Bone Mineral ◽  
Dual Energy ◽  
Normal Body Mass Index ◽  
Mineral Density ◽  
X Ray ◽  
T Score ◽  
The Mean

Introduction. Osteoporosis is a metabolic skeletal disease characterized by bone mineral density reduction, which may lead to an increased risk of bone fractures. Obesity is a condition of excessive body fat that causes or aggravates many public health problems. As it is easy to be measured, body mass index is widely used as an index of the degree of obesity. Material and Methods. The study included 1.372 female orthopedic patients between the ages of 30 to 79 years who visited the Clinical Centre of Vojvodina in Novi Sad to have a dual-energy x-ray absorptiometry (DEXA) examination in the period from March, 2010 to June, 2013. The following anthropometric data were collected: body mass index, body weight, height, dual-energy x-ray absorptiometry T-score and bone mineral density (BMD), as well as some other data. Results. The mean age was 62.08 years, the mean weight was 73.59 kg and the mean height was 1.6 m. There were 392 participants in the group of normal body mass index, 14 participants were underweight, and 966 were overweight and obese. In the overweight and obese group, 25.25% participants had osteoporosis, 35.4% had osteopenia and 39.33% had the normal T-score. In the normal body mass index group, 42.34% of the participants had osteoporosis, 29.3% had osteopenia and 28.31 had the normal T-score. In the underweight group, 57.14% of the participants had osteoporosis, 21.42% had osteopenia and 21.42% had the normal T-score. Conclusion. No strong correlation between body mass index and bone mineral density was found in our study, but it is obvious that there was a stronger correlation between body mass index and bone mineral density of the total hip than between body mass index and bone mineral density of the lumbar spine.

scholarly journals Comparison of T-score values obtained by ultrasound osteodensitometry of calcaneus and by dual-energy x-ray absorptiometry scan

2015 ◽  
Vol 68 (9-10) ◽  
pp. 341-346
Author(s):  
Aleksandra Hadziavdic ◽  
Natasa Vajic ◽  
Nikola Gavric
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Metabolic Disease ◽  
Quantitative Ultrasound ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
Female Patients ◽  
T Score ◽  
Significant Difference

Introduction. Osteoporosis is the most frequent metabolic disease of bones. Early detection of pathological loss of bone mineral density represents the first step in prevention, treatment and rehabilitation of osteoporosis. This study was aimed at establishing the correlation of T-score values obtained by ultrasound osteodensitometry of calcaneus with dual-energy x-ray absorptiometry scan. Material and Methods. The study was conducted on the sample of 569 female patients from September 13, 2010 to March 10, 2011. Measurement was made with ultrasound osteodensitometry of ACHILLES make. Quantitative ultrasound method revealed that 77 female patients had a lower value of T-score (osteopenia with risk factors or osteoporosis) and they were referred to T-score measurement with dual-energy x-ray absorptiometry scan. Dual-energy x-ray absorptiometry scanning was performed using LUNAR DPX scanner and 49 female patients were examined. Results. It was concluded that there was no statistically significant difference between T-score values obtained by quantitative ultrasound and dual-energy x-ray absorptiometry scanning. Conclusion. According to this study, it is necessary to provide a greater number of scanners for ultrasound osteodensitometry of calcaneus in order to secure prevention and to refer the patients to further diagnosing on time.

Bone Mineral Density Measurement in Menopausal Women Presenting with Low Back Pain: A Prospective Study

1970 ◽  
Vol 15 (2) ◽  
pp. 64-67
Author(s):  
Selim M Ansari ◽  
T Begum ◽  
AB Siddique
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Density Measurement ◽  
Low Back ◽  
Mineral Density ◽  
X Ray ◽  
Normal Bone Mineral Density ◽  
First Choice ◽  
Menopausal Women ◽  
Post Menopausal

Bone mineral densitometry was done in 107 women in their post-menopausal period using Dualenergy X-ray absorptiometry method. All the patients were presented with low back pain.Quantification of bone mineral density was done in proximal femur and lumber spines of all thepatients. Sixty-eight patients showed normal bone mineral density in our study. Rest 39 patientsshowed declination of bone mineral density from mild osteopenia to severe osteoporosis. Weconclude that Dual energy X-ray absorptiometry bone mineral measurement is an unique, noninvasivemethod of detecting bone mass disorder in post-menopausal women with low backpain and should be the first choice of investigation.doi: 10.3329/taj.v15i2.3909TAJ December 2002; Vol.15(2):64-67

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